Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Carl K Edwards"'
Abstract 5134: PD-1/PD-L1 signalling axis, 'a double-edged sword' in DSS induced colitis mouse model
Autor:
Tao Yang, Rongfei Lu, kaixia lian, Likun Zhang, Dawei Wang, Xinhe Feng, Xiaoyu An, Jessie (Jingjing) Wang, Carl K. Edwards
Publikováno v:
Cancer Research. 83:5134-5134
Background. Immune checkpoint molecules are essential for modulating immune responses and maintaining self-tolerance. While immune checkpoint inhibitors have improved the treatment of a broad spectrum of cancers, many of them are also believed to pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::002a4f2c2e1d080938b0e10618135c10
https://doi.org/10.1158/1538-7445.am2023-5134
https://doi.org/10.1158/1538-7445.am2023-5134
Autor:
Tao Yang, Rongfei Lu, Xiaofei Xu, Likun Zhang, Dawei Wang, Xinhe Feng, Xiaoyu An, Jessie (Jingjing) Wang, Xianfei He, Carl K. Edwards
Publikováno v:
Cancer Research. 83:5133-5133
Background. Th2 cytokines (e.g. IL-4, IL-5, IL13) drive defined allergic reactions and various autoimmune and inflammatory diseases including atopic dermatitis (AD), asthma and rhinitis. IL-4Ra is a receptor shared by both IL-4 and IL-13, thus blocki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ce7e5f2004800d4c0cacdf431f7cefe
https://doi.org/10.1158/1538-7445.am2023-5133
https://doi.org/10.1158/1538-7445.am2023-5133
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 10, Pp 17411-17441 (2014)
CD147 or EMMPRIN is a member of the immunoglobulin superfamily in humans. It is widely expressed in human tumors and plays a central role in the progression of many cancers by stimulating the secretion of matrix metalloproteinases (MMPs) and cytokine
Externí odkaz:
https://doaj.org/article/3b8a301e9b744b4496ed7c6791af38e3
Autor:
Rajiv Datar, Carlo Marchetti, Benjamin J Swartzwelter, Charles A. Dinarello, Carl K. Edwards, Uli Binder, Martin Schlapschy, Arne Skerra, Dennis M. de Graaf, Nicholas E. Powers, Alexandra Lerchner
Publikováno v:
J Biol Chem
Journal of Biological Chemistry, 295, 3, pp. 868-882
Journal of Biological Chemistry, 295, 868-882
Journal of Biological Chemistry, 295, 3, pp. 868-882
Journal of Biological Chemistry, 295, 868-882
Interleukin-1 (IL-1) is a key mediator of inflammation and immunity. Naturally-occurring IL-1 receptor antagonist (IL-1Ra) binds and blocks the IL-1 receptor-1 (IL-1R1), preventing signaling. Anakinra, a recombinant form of IL-1Ra, is used to treat a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4c17b1368a9c115cafec49dfdb8696
https://doi.org/10.1016/s0021-9258(17)49941-8
https://doi.org/10.1016/s0021-9258(17)49941-8
Autor:
Carl K Edwards, Julie Schwartz Green, Hans-Dieter eVolk, Michael eSchiff, Brian eKotzin, Hiroaki eMitsuya, Tatsuya eKawaguchi, Ken-Mei eSakata, John eCheronis, David eTrollinger, Danute eBankaitis-Davis, Charles A Dinarello, David A Norris, Michael P Bevilacqua, Mayumi eFujita, Gerd-Rudiger eBermester
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Periodic assessment of gene expression for diagnosis and monitoring in rheumatoid arthritis (RA) may provide a readily available and useful method to detect subclinical disease progression and follow responses to therapy with disease modifying anti-r
Externí odkaz:
https://doaj.org/article/26c53648e1dd4833a48869d86ab24e2e
Autor:
Yuchun Luo, Steven Robinson, Junichi Fujita, Lisa Siconolfi, Jay Magidson, Carl K Edwards, Karl Wassmann, Kathleen Storm, David A Norris, Danute Bankaitis-Davis, William A Robinson, Mayumi Fujita
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20971 (2011)
Developing analytical methodologies to identify biomarkers in easily accessible body fluids is highly valuable for the early diagnosis and management of cancer patients. Peripheral whole blood is a "nucleic acid-rich" and "inflammatory cell-rich" inf
Externí odkaz:
https://doaj.org/article/9232f5c6edea4dff9e9c88cc98796c1f
Autor:
Bentitez Diego, Joseph S. Solomkin, Carl K. Edwards, Shalyn J. Lane, Timothy J. Deming, Michael P. Bevilacqua, Huang Daniel J, Jarrod A. Hanson, Brian D. Wall
Publikováno v:
Macromolecular Bioscience, vol 17, iss 10
Author(s): Bevilacqua, Michael P; Huang, Daniel J; Wall, Brian D; Lane, Shalyn J; Edwards, Carl K; Hanson, Jarrod A; Benitez, Diego; Solomkin, Joseph S; Deming, Timothy J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e59cda27925ea5d929d4db77808aa84
https://escholarship.org/uc/item/57c4d79k
https://escholarship.org/uc/item/57c4d79k
Autor:
Brian D. Wall, Huang Daniel J, Shalyn J. Lane, Carl K. Edwards, Michael P. Bevilacqua, Joseph S. Solomkin, Timothy J. Deming, Bentitez Diego, Jarrod A. Hanson
Publikováno v:
Macromolecular bioscience, vol 17, iss 10
Bevilacqua, MP; Huang, DJ; Wall, BD; Lane, SJ; III, ECK; Hanson, JA; et al.(2017). Amino Acid Block Copolymers with Broad Antimicrobial Activity and Barrier Properties. MACROMOLECULAR BIOSCIENCE, 17(10). doi: 10.1002/mabi.201600492. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5qt5d9bh
Bevilacqua, MP; Huang, DJ; Wall, BD; Lane, SJ; III, ECK; Hanson, JA; et al.(2017). Amino Acid Block Copolymers with Broad Antimicrobial Activity and Barrier Properties. MACROMOLECULAR BIOSCIENCE, 17(10). doi: 10.1002/mabi.201600492. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5qt5d9bh
Antimicrobial properties of a long-chain, synthetic, cationic, and hydrophobic amino acid block copolymer are reported. In 5 and 60 min time-kill assays, solutions of K100 L40 block copolymers (poly(l-lysine·hydrochloride)100 -b-poly(l-leucine)40 )
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f857db008649a855446eb4d83c00ae
https://escholarship.org/uc/item/5qt5d9bh
https://escholarship.org/uc/item/5qt5d9bh
Autor:
Zhiyao He, Yuquan Wei, Xiawei Wei, Bingyang Chu, Gu He, Zhiyong Qian, Carl K. Edwards, Xiangrong Song, Yongmei Xie, Jiao Li
Publikováno v:
International Journal of Pharmaceutics. 469:168-178
Poly(ethylene glycol)-cholesterol (PEG-Chol) conjugates are composed of "hydrophilically-flexible" PEG and "hydrophobically-rigid" Chol molecules. PEG-Chol conjugates are capable of forming micelles through molecular self-assembly and they are also u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bea1cd41d3fe7631b7d7adc68001226
https://doi.org/10.1016/j.ijpharm.2014.04.056
https://doi.org/10.1016/j.ijpharm.2014.04.056
Autor:
Guobo Shen, Jingyi Zhao, Jingyu Li, Carl K. Edwards, Yuquan Wei, Shimin Wang, Wei Wang, Xiang Gao
Publikováno v:
Scientific Reports
Regulatory T cells (Tregs) expand in peripheral lymphoid organs and can produce immunosuppressive cytokines to support tumor growth. IL-10 abrogation efficiently induces Treg formation but dampens tumoral neuropilin-1 (Nrp-1) Treg signaling, which si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e18f8132b2161ef3e2bc93432cab88