Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Carl J, Johnston"'
Autor:
Angela L. Hughson, Gary Hannon, Noah A. Salama, Tara G. Vrooman, Caroline A. Stockwell, Bradley N. Mills, Jesse Garrett-Larsen, Haoming Qiu, Roula Katerji, Lauren Benoodt, Carl J. Johnston, Joseph D. Murphy, Emma Kruger, Jian Ye, Nicholas W. Gavras, David C. Keeley, Shuyang S. Qin, Maggie L. Lesch, Jason B. Muhitch, Tanzy M.T. Love, Laura M. Calvi, Edith M. Lord, Nadia Luheshi, Jim Elyes, David C. Linehan, Scott A. Gerber
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 4, Pp 102350- (2024)
Pronounced T cell exhaustion characterizes immunosuppressive tumors, with the tumor microenvironment (TME) employing multiple mechanisms to elicit this suppression. Traditional immunotherapies, such as immune checkpoint blockade, often fail due to th
Externí odkaz:
https://doaj.org/article/f027f2b3c534440cbdc1ca41fe01b771
Autor:
Alexandra O. Strohm, Sadie Oldfield, Eric Hernady, Carl J. Johnston, Brian Marples, M. Kerry O'Banion, Ania K. Majewska
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 43, Iss , Pp 100911- (2025)
Patients receiving cranial radiation therapy experience tissue damage and cognitive deficits that severely decrease their quality of life. Experiments in rodent models show that these adverse neurological effects are in part due to functional changes
Externí odkaz:
https://doaj.org/article/68b350547d9c45dbad12699d5a1a73fb
Autor:
Jian Ye, Brian A Belt, David C Linehan, Tara G Vrooman, Carl J Johnston, Edith M Lord, Scott A Gerber, Nicholas W Gavras, David C Keeley, Angela L Hughson, Gary Hannon, Maggie L Lesch, Jim Eyles
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Stereotactic body radiotherapy (SBRT) induces immunogenic cell death, leading to subsequent antitumor immune response that is in part counterbalanced by activation of immune evasive processes, for example, upregulation of programmed cell d
Externí odkaz:
https://doaj.org/article/df0812d98765426e92ae92d48cf997b7
Autor:
Thomas N. O’Connor, Jacob G. Kallenbach, Haley M. Orciuoli, Nicole D. Paris, John F. Bachman, Carl J. Johnston, Eric Hernady, Jacqueline P. Williams, Robert T. Dirksen, Joe V. Chakkalakal
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Background Radiotherapy is commonly used to treat childhood cancers and can have adverse effects on muscle function, but the underlying mechanisms have yet to be fully elucidated. We hypothesized that endurance exercise following radiation t
Externí odkaz:
https://doaj.org/article/ecc26d38809d447f86a80307ebda6bc4
Autor:
Jacob G. Kallenbach, John F. Bachman, Nicole D. Paris, Roméo S. Blanc, Thomas O'Connor, Esraa Furati, Eric Hernady, Carl J. Johnston, Jacqueline P. Williams, Joe V. Chakkalakal
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 296-310 (2022)
Abstract Background As paediatric cancer survivors are living into adulthood, they suffer from the age‐related, accelerated decline of functional skeletal muscle tissue, termed sarcopenia. With ionizing radiation (radiotherapy) at the core of paedi
Externí odkaz:
https://doaj.org/article/65609b7e38e04fbdb3872959e7da9f5f
Autor:
Angela M. Groves, Carl J. Johnston, Gisela G. Beutner, Jane E. Dahlstrom, Mark Koina, Michael A. O'Reilly, George Porter, Patrick D. Brophy, Alison L. Kent
Publikováno v:
Physiological Reports, Vol 10, Iss 24, Pp n/a-n/a (2022)
Abstract Hypoxic ischemic encephalopathy (HIE) is associated with acute kidney injury (AKI) in neonates with birth asphyxia. This study aimed to utilize urinary biomarkers to characterize AKI in an established neonatal rat model of HIE. Day 7 Sprague
Externí odkaz:
https://doaj.org/article/666f53fc97c046118c02b61e3050900d
Autor:
Hitoshi Uchida, Matthew H. Ingalls, Eri O. Maruyama, Carl J. Johnston, Eric Hernady, Roberta C. Faustoferri, Catherine E. Ovitt
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 11 (2022)
Externí odkaz:
https://doaj.org/article/9015369b106e49a5a3f815fd66a2506e
Autor:
Daniel P. Croft, David S. Burton, David J. Nagel, Soumyaroop Bhattacharya, Ann R. Falsey, Steve N. Georas, Philip K. Hopke, Carl J. Johnston, R. Matthew Kottmann, Augusto A. Litonjua, Thomas J. Mariani, David Q. Rich, Kelly Thevenet-Morrison, Sally W. Thurston, Mark J. Utell, Matthew N. McCall
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Combustion related particulate matter air pollution (PM) is associated with an increased risk of respiratory infections in adults. The exact mechanism underlying this association has not been determined. We hypothesized that increased concen
Externí odkaz:
https://doaj.org/article/f504fe72eea34f34b71bf81db1a6ebe3
Autor:
Jian Ye, Brian A Belt, Booyeon J Han, David C Linehan, Shuyang S Qin, Bradley N Mills, Jesse Garrett-Larsen, Joseph D Murphy, Taylor P Uccello, Tara G Vrooman, Carl J Johnston, Edith M Lord, Scott A Gerber
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Stereotactic body radiotherapy (SBRT) has been increasingly used as adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC), and induces immunogenic cell death, which leads to the release of tumor antigen and damage-associated molecula
Externí odkaz:
https://doaj.org/article/54b3ed967a784f7b9badf62aea058989
Autor:
Taylor P. Uccello, MS, Sarah A. Kintzel, BS, Bradley N. Mills, PhD, Joseph D. Murphy, MS, Jesse Garrett-Larsen, BS, Nicholas G. Battaglia, PhD, Carlos J. Rodriguez, BS, Michael G. Drage, MD, Jian Ye, PhD, Tanzy M.T. Love, PhD, Carl J. Johnston, PhD, Elizabeth A. Repasky, PhD, Haoming Qiu, MD, David C. Linehan, MD, Edith M. Lord, PhD, Scott A. Gerber, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 2, Pp 100867- (2022)
Purpose: Orthotopic tumors more closely recapitulate human cancers than do ectopic models; however, precision targeting of such internal tumors for radiation therapy (RT) without inducing systemic toxicity remains a barrier. We developed an innovativ
Externí odkaz:
https://doaj.org/article/e6a54b79ca5a4a35a5fb31b880e6b168