Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Carl Herdenberg"'
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0289726 (2023)
Leucine-rich repeats and immunoglobulin-like domains (LRIG) are transmembrane proteins shown to promote bone morphogenetic protein (BMP) signaling in Caenorhabditis elegans, Drosophila melanogaster, and mammals. BMPs comprise a subfamily of the trans
Externí odkaz:
https://doaj.org/article/65602ebf251f43d2b19bd7ce7e413980
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Netrin-1 is a secreted protein that is well known for its involvement in axonal guidance during embryonic development and as an enhancer of cancer cell metastasis. Despite extensive efforts, the molecular mechanisms behind many of the physio
Externí odkaz:
https://doaj.org/article/28591f96dd0a4e8aaa555ae108212a98
Autor:
Carl Herdenberg, Pascal M. Mutie, Ola Billing, Ahmad Abdullah, Rona J. Strawbridge, Ingrid Dahlman, Simon Tuck, Camilla Holmlund, Peter Arner, Roger Henriksson, Paul W. Franks, Håkan Hedman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and
Externí odkaz:
https://doaj.org/article/2dabfe4ef579463aa23b059fe23b8acc
Autor:
Oskar Franklin, Ola Billing, Daniel Öhlund, Anette Berglund, Carl Herdenberg, Wanzhong Wang, Urban Hellman, Malin Sund
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 5, Iss 2, Pp 130-141 (2019)
Abstract The dense stroma in pancreatic cancer tumours is rich in secreted extracellular matrix proteins and proteoglycans. Secreted hyaluronan, osteopontin and type IV collagen sustain oncogenic signalling by interactions with CD44s and its variant
Externí odkaz:
https://doaj.org/article/daafc6812e4b40a48a53a6037d01fc30
Autor:
Urban Hellman, Carl Herdenberg, Oskar Franklin, Malin Sund, Anette Berglund, Daniel Öhlund, Ola Billing, Wanzhong Wang
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 5, Iss 2, Pp 130-141 (2019)
The Journal of Pathology: Clinical Research
The Journal of Pathology: Clinical Research
The dense stroma in pancreatic cancer tumours is rich in secreted extracellular matrix proteins and proteoglycans. Secreted hyaluronan, osteopontin and type IV collagen sustain oncogenic signalling by interactions with CD44s and its variant isoform C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3376055c1780b8b5fd1fd53f91af21a2
https://doi.org/10.1002/cjp2.122
https://doi.org/10.1002/cjp2.122
Autor:
Ahmad Sharmi Abdullah, Ingrid Dahlman, Pascal M. Mutie, Peter Arner, Paul W. Franks, Rona J. Strawbridge, Carl Herdenberg, Håkan Hedman, Simon Tuck, Roger Henriksson, Ola Billing, Camilla Holmlund
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins have been implicated as regulators of growth factor signaling; however, the possible redundancy among mammalian LRIG1, LRIG2, and LRIG3 has hindered detailed elucidation of their ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e64ae46f13fd73d87a2f5e3afcde376
http://europepmc.org/articles/PMC7815736
http://europepmc.org/articles/PMC7815736
Autor:
Ola Billing, Malin Jansson, Christina Lundin, Carl Herdenberg, Malin Sund, Egle Tolockiene, Anoosheh Nazemroaya
Publikováno v:
Journal of mammary gland biology and neoplasia. 25(1)
Localised breast cancer can be cured by surgery and adjuvant treatments, but mortality remains high as some tumours metastasize early. Perlecan is a basement membrane (BM) protein involved in tumour development and progression. Here, mRNA and protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94ec0edd3e3c7bf284a915d3999b82b
https://pubmed.ncbi.nlm.nih.gov/32124140
https://pubmed.ncbi.nlm.nih.gov/32124140
Autor:
Håkan Hedman, Roger Henriksson, Catharina Larsson, Fernando Cruz Alsina, Jo W.M. Höppener, David Lindquist, Miklós Tarján, Carl Herdenberg, Gustavo Paratcha, Na Wang, Tibor Tot
Publikováno v:
International Journal of Oncology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Papillary thyroid carcinoma (PTC) and medullary thyroid carcinoma (MTC) are characterized by genomic rearrangements and point mutations in the proto-oncogene RET. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a suppressor of vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e754280297cbc101d44820bad4dfae87
https://pubmed.ncbi.nlm.nih.gov/29436694
https://pubmed.ncbi.nlm.nih.gov/29436694
Publikováno v:
The Journal of Biological Chemistry
Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) is a tumor suppressor and a negative regulator of several receptor tyrosine kinases. The molecular mechanisms by which LRIG1 mediates its tumor suppressor effects and regulates receptor t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d351439c5fc71be725a1a775b9a780
https://pubmed.ncbi.nlm.nih.gov/29317492
https://pubmed.ncbi.nlm.nih.gov/29317492
Autor:
Håkan Hedman, Carl Herdenberg
Publikováno v:
Cancer Research. 77:5539-5539
The LRIG gene family consists of LRIG1, LRIG2 and LRIG3. The most studied of these is LRIG1, which is a tumor suppressor gene. The LRIG1 protein is downregulated in various types of cancer and it negatively regulates receptor tyrosine kinases includi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1282b421c553a8781db1ea0ca9b52248
https://doi.org/10.1158/1538-7445.am2017-5539
https://doi.org/10.1158/1538-7445.am2017-5539