Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing

Autor: Jérôme Nicod, Joseph Wood, Jean-Marie Launay, Benjamin K Yee, Arimantas Lionikas, Connie R. Bezzina, Amarjit Bhomra, Jacques Callebert, Robert W. Davies, Martin Fray, Tertius Hough, Cormac Cosgrove, Barbara Nell, Leo Goodstadt, Elisabeth M. Lodder, Richard Mott, Hayley Phelps, Jonathan Flint, Paul Klenerman, Vikte Lionikaite, Paul Franken, Steve D. M. Brown, Paul Potter, Carl Hassett, Yigal M. Pinto, Sara Wells, Alison Walling, Richard M. Aspden, Nasrin Bopp, Russell Joynson, David J. Adams, Jennifer S. Gregory, Rebecca E. McIntyre, Nick P. Talbot, Tom Weaver, Na Cai, David A. Blizard, Mark Harrison, Polinka Hernandez-Pliego, Carol Ann Remme, Peter A. Robbins, Clare Rowe

Publikováno v: Nature genetics, 48(8), 912-918. Nature Publishing Group
Nature genetics
Nature Genetics
Nature Genetics, vol. 48, no. 8, pp. 912-918

Two bottlenecks impeding the genetic analysis of complex traits in rodents are access to mapping populations able to deliver gene-level mapping resolution and the need for population-specific genotyping arrays and haplotype reference panels. Here we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c43f733d0e02d16156ca7a0f9e4be1
https://doi.org/10.1038/ng.3595