Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Carl Friedrich Nising"'
Autor:
Benjamin Bader, Sabine Zitzmann-Kolbe, Carl Friedrich Nising, Ulrich Lücking, Qi Wang, Hartmut Rehwinkel, Florian Bartels, Qiuwen Wang, Markus Berger, Antje Margret Wengner, Lars Wortmann, Dieter Moosmayer, Philipp Buchgraber, Hans Briem, Dominik Mumberg, Knut Eis, Uwe Eberspächer, Stefanie Hammer, Christoph A. Schatz, Gerhard Siemeister, Philip Lienau, Ulf Bömer
Publikováno v:
Journal of Medicinal Chemistry. 64:12723-12737
Eukaryotes have evolved two major pathways to repair potentially lethal DNA double-strand breaks. Homologous recombination represents a precise, DNA-template-based mechanism available during the S and G2 cell cycle phase, whereas non-homologous end j
Autor:
Niels Böhnke, Markus Berger, Nils Griebenow, Antje Rottmann, Michael Erkelenz, Stefanie Hammer, Sandra Berndt, Judith Günther, Antje M. Wengner, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Jörißen, Naomi Barak, Ulf Bömer, Roman C. Hillig, Uwe Eberspaecher, Jörg Weiske, Anja Giese, Dominik Mumberg, Carl Friedrich Nising, Hilmar Weinmann, Anette Sommer
Publikováno v:
Bioconjugate chemistry. 33(6)
Inhibition of intracellular nicotinamide phosphoribosyltransferase (NAMPT) represents a new mode of action for cancer-targeting antibody-drug conjugates (ADCs) with activity also in slowly proliferating cells. To extend the repertoire of available ef
Autor:
Andrea Hägebarth, Carl Friedrich Nising, Philip Lienau, Julien Lefranc, Benjamin Bader, Clara D. Christ, Volker K Schulze, Clara Lemos, Simon Holton, Tobias Heinrich, Ulf Bömer, Franz von Nussbaum, Hans Briem, Ekaterina Nevedomskaya, Simon J. Baumgart, Dominik Mumberg, Bernard Haendler, Marcus Bauser, Lara Kuhnke
Publikováno v:
Cellular Oncology. 44:581-594
5′ adenosine monophosphate-activated kinase (AMPK) is an essential regulator of cellular energy homeostasis and has been associated with different pathologies, including cancer. Precisely defining the biological role of AMPK necessitates the availa
Autor:
Carl Friedrich Nising
Publikováno v:
Forschung & Lehre.
Autor:
Volker Schulze, Franz von Nussbaum, Clara Lemos, Philip Lienau, Ulf Bömer, Clara Christ, Marcus Bauser, Carl Friedrich Nising, Simon J. Baumgart, Simon Holton, Tobias Heinrich, Hans Briem, Benjamin Bader, Bernard Haendler, Julien Lefranc, Andrea Hägebarth, Dominik Mumberg, Ekaterina Nevedomskaya, Lara Kuhnke
Background: 5´ adenosine monophosphate-activated kinase (AMPK) is an essential regulator of cellular energy homeostasis which has been associated with different pathologies, including cancer. Precisely defining the role of AMPK in these processes ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de28afe92f682da433e5d167b7b11ea8
https://doi.org/10.21203/rs.3.rs-47637/v1
https://doi.org/10.21203/rs.3.rs-47637/v1
Autor:
Antje Margret Wengner, Hans Briem, Stefan Gradl, Srinivasan Rengachari, Tobias Heinrich, Carl Friedrich Nising, Detlef Stöckigt, Franz von Nussbaum, Ulf Bömer, Julien Lefranc, Benjamin Bader, Anne Mengel, Dominik Mumberg, Roman C. Hillig, Volker K Schulze, Florian Prinz, Daniel Panne, József Bálint, Horst Irlbacher
Publikováno v:
Journal of medicinal chemistry. 63(2)
The serine/threonine kinase TBK1 (TANK-binding kinase 1) and its homologue IKKe are noncanonical members of the inhibitor of the nuclear factor κB (IκB) kinase family. These kinases play important roles in multiple cellular pathways and, in particu
Publikováno v:
Angewandte Chemie International Edition. 55:15982-15988
Owing to their high occurrence rate across many human cancers and their lack of druggability so far, mutant forms of the signaling protein Ras are currently among the most attractive (and elusive) oncology targets. This strong appeal explains the sus
Publikováno v:
Angewandte Chemie. 128:16215-16221
Ras-Mutanten zahlen wegen ihres haufigen Auftretens bei vielen menschlichen Krebsarten und ihrer geringen Adressierbarkeit durch Wirkstoffe (niedrige “druggability”) derzeit zu den gesuchtesten (und anspruchsvollsten) onkologischen Targets. Hierd
Autor:
Franziska Siegel, Carl Friedrich Nising, Franz von Nussbaum, Ulf Boemer, Herbert Himmel, Detlev Suelzle, Marcus Bauser, Uwe Eberspaecher, Simon Holton, Joerg Weiske, Florian Prinz, Ralf Lesche, Clara Lemos, Dominik Mumberg, Dieter Moosmayer, Knut Eis, Andrea Haegebarth, Stefan Prechtl, Barbara Nicke, Duy Nguyen, Lars Wortmann, Christian Lechner, Katrin Nowak-Reppel
Publikováno v:
Journal of medicinal chemistry. 62(2)
The availability of a chemical probe to study the role of a specific domain of a protein in a concentration- and time-dependent manner is of high value. Herein, we report the identification of a highly potent and selective ERK5 inhibitor BAY-885 by h
Autor:
Christoph Schatz, Frank Dittmer, Joachim Schuhmacher, Stefanie Hammer, Charlotte Christine Kopitz, Manuela Braun, Beatrix Stelte-Ludwig, Anette Sommer, Sabine Wittemer-Rump, Bertolt Kreft, Simone Greven, Hung Huynh, Heiner Apeler, Carl Friedrich Nising, Hans-Georg Lerchen, Christoph Mahlert, Axel Harrenga, Karl Ziegelbauer, Rolf Jautelat, Frank Reetz, Ruprecht Zierz
Publikováno v:
Cancer Research. 76:6331-6339
The fibroblast growth factor receptor FGFR2 is overexpressed in a variety of solid tumors, including breast, gastric, and ovarian tumors, where it offers a potential therapeutic target. In this study, we present evidence of the preclinical efficacy o