Výsledky vyhledávání - "Carl F. Beyer"

Data from TTI-237: A Novel Microtubule-Active Compound with In vivo Antitumor Activity

Autor: James J. Gibbons, Semiramis Ayral-Kaloustian, Carolyn Discafani, Thai Nguyen, Judy Lucas, Danielle Vitale, Richard Hernandez, Nan Zhang, Carl F. Beyer

5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine butanedioate (TTI-237) is a microtubule-active compound of novel structure and function. Structurally, it is one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ac1bf6199fe9d451e181b4e511fa7d
https://doi.org/10.1158/0008-5472.c.6496545

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The microtubule-active antitumor compound TTI-237 has both paclitaxel-like and vincristine-like properties

Autor: Nan Zhang, James Joseph Gibbons, Nguyen Thai Hiep, Danielle Vitale, Semiramis Ayral-Kaloustian, Carl F. Beyer, Richard Hernandez

Publikováno v: Cancer Chemotherapy and Pharmacology. 64:681-689

To compare TTI-237 (5-chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-[1, 2, 4]triazolo[1,5-a]pyrimidin-7-amine butanedioate) with paclitaxel and vincristine in order to better understand the properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65da1650177700eea2eb1ebc4aeb001d
https://doi.org/10.1007/s00280-008-0916-2

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TTI-237: A Novel Microtubule-Active Compound with In vivo Antitumor Activity

Autor: Nguyen Thai Hiep, Danielle Vitale, Judy Lucas, Nan Zhang, Carl F. Beyer, James Joseph Gibbons, Richard Hernandez, Semiramis Ayral-Kaloustian, Carolyn Discafani

Publikováno v: Cancer Research. 68:2292-2300

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fae0fc496b1b25ddde519260b68cb36
https://doi.org/10.1158/0008-5472.can-07-1420

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A Calicheamicin Conjugate with a Fully Humanized Anti-MUC1 Antibody Shows Potent Antitumor Effects in Breast and Ovarian Tumor Xenografts

Autor: Dan Shochat, Carl F. Beyer, Janis Upeslacis, Lois M Hinman, Delores Lindh, Hamann Philip Ross, Andrew Mountain

Publikováno v: Bioconjugate Chemistry. 16:354-360

Murine CTM01 is an internalizing murine IgG(1) monoclonal antibody that recognizes the MUC1 antigen expressed on many solid tumors of epithelial origin. Calicheamicin conjugates of this antibody have previously been shown to be potent, selective anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1468c0e746ba6c8074301859ea518c7e
https://doi.org/10.1021/bc049794n

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An Anti-CD33 Antibody−Calicheamicin Conjugate for Treatment of Acute Myeloid Leukemia. Choice of Linker

Autor: Lois M. Hinman, Philip R. Hamann, Irwin D. Bernstein, Carl F. Beyer, Delores Lindh, Janis Upeslacis, David A. Flowers

Publikováno v: Bioconjugate Chemistry. 13:40-46

The anti-CD33 antibody, P67.6, has been chosen to target the potently cytotoxic calicheamicin antitumor antibiotics to acute myeloid leukemia (AML) due to the presence of CD33 on >80% of patient samples and its lack of expression outside the myeloid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec25ca0066d548feea3238290084e715
https://doi.org/10.1021/bc0100206

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Synthesis and SAR of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents

Autor: Nan Zhang, Semiramis Ayral-Kaloustian, Nguyen Thai Hiep, Judy Lucas, Carolyn Discafani, Richard Hernandez, Carl F. Beyer

Publikováno v: Bioorganicmedicinal chemistry. 17(1)

The synthesis and SAR of a series of 6-chloro-4-fluoroalkylamino-2-heteroaryl-5-(substituted)phenylpyrimidines as anti-cancer agents are described. This series of 2-heteroarylpyrimidines was developed by modifying a series of anti-tumor [1,2,4]triazo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e44124b88144d7b43f6358d396c586
https://pubmed.ncbi.nlm.nih.gov/19041247

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Preclinical pharmacologic evaluation of MST-997, an orally active taxane with superior in vitro and in vivo efficacy in paclitaxel- and docetaxel-resistant tumor models

Autor: Carol Rios, Lee M. Greenberger, Carolyn Discafani, Carl F. Beyer, Sharon Yang, Hao Liu, Michelle Baxter, Deepak Sampath, Malathi Hari

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 12(11 Pt 1)

Purpose: Because resistance to paclitaxel and docetaxel is frequently observed in the clinic, new anti-microtubule agents have been sought. The aim of this study was to evaluate the efficacy and oral activity of a novel taxane (MST-997) in paclitaxel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c89d142aa49c6e6284e6d7fe40a668
https://pubmed.ncbi.nlm.nih.gov/16740771

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Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells

Autor: Yanong D. Wang, Carl F. Beyer, Carolyn Discafani, Lee D. Jennings, Scott L. Kincaid, Girija Krishnamurthy, Sridhar K. Rabindran, John P. McGinnis, Miriam Miranda

Publikováno v: Bioorganicmedicinal chemistry letters. 15(21)

A novel series of inhibitors of cancer cell proliferation, selective against p21 cell cycle checkpoint-disrupted cells vs. cells with intact p21 checkpoint, were identified by high-throughput screening. Optimization of both ends of the lead molecule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2555d795fe1237613225f6a11922de
https://pubmed.ncbi.nlm.nih.gov/16143523

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An anti-MUC1 antibody-calicheamicin conjugate for treatment of solid tumors. Choice of linker and overcoming drug resistance

Autor: Lee M. Greenberger, Clara Lin, Rosalyn Wallace, Lois M Hinman, Carl F. Beyer, Delores Lindh, Janis Upeslacis, Hamann Philip Ross, Frederick E. Durr, Ana T. Menendez

Publikováno v: Bioconjugate chemistry. 16(2)

The anti-MUC1 antibody, CTM01, has been chosen to target the potently cytotoxic calicheamicin antitumor antibiotics to solid tumors of epithelial origin that express this antigen. Earlier calicheamicin conjugates relied on the attachment of a hydrazi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5708723b0f9d3569176f2ff13dff0c
https://pubmed.ncbi.nlm.nih.gov/15769088

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