Zobrazeno 1 - 10
of 322
pro vyhledávání: '"Carl E, Stafstrom"'
Autor:
Juliet K. Knowles, Aaron E. L. Warren, Ismail S. Mohamed, Carl E. Stafstrom, Hyun Yong Koh, Debopam Samanta, Renée A. Shellhaas, Gita Gupta, Tracy Dixon‐Salazar, Linh Tran, Sonal Bhatia, Jane M. McCabe, Anup D. Patel, Zachary M. Grinspan
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 11, Pp 2818-2835 (2024)
Abstract Objective: Lennox‐Gastaut syndrome (LGS) is a severe, childhood‐onset epilepsy that is typically refractory to treatment. We surveyed the current landscape of LGS treatment, aiming to identify challenges to the development of efficacious
Externí odkaz:
https://doaj.org/article/ae3f58cf268a4683824847ecd37e6238
Autor:
Li-Rong Shao, Feng Gao, Viveka Chinnasamy, Yasuhiro Kazuki, Mistuo Oshimura, Roger H. Reeves, Carl E. Stafstrom
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106198- (2023)
Children with Down syndrome (DS, trisomy of chromosome 21) have an increased risk of infantile spasms (IS). As an epileptic encephalopathy, IS may further impair cognitive function and exacerbate neurodevelopmental delays already present in children
Externí odkaz:
https://doaj.org/article/11c1f9952d6547a59d297f251d21842c
Publikováno v:
Epilepsia Open, Vol 7, Iss 1, Pp 181-186 (2022)
Abstract Infantile spasms (IS) is an epileptic encephalopathy with a poor neurodevelopmental prognosis, and limited, often ineffective treatment options. The effectiveness of metabolic approaches to seizure control is being increasingly shown in a wi
Externí odkaz:
https://doaj.org/article/7cd5f3d6454a4e1195e5b34d3bf1f025
Autor:
Kengo Onda, Eva Catenaccio, Jill Chotiyanonta, Raul Chavez-Valdez, Avner Meoded, Bruno P. Soares, Aylin Tekes, Harisa Spahic, Sarah C. Miller, Sarah-Jane Parker, Charlamaine Parkinson, Dhananjay M. Vaidya, Ernest M. Graham, Carl E. Stafstrom, Allen D. Everett, Frances J. Northington, Kenichi Oishi
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Hypoxic–ischemic encephalopathy (HIE) is the most common cause of neonatal acquired brain injury. Although conventional MRI may predict neurodevelopmental outcomes, accurate prognostication remains difficult. As diffusion tensor imaging (DTI) may p
Externí odkaz:
https://doaj.org/article/bfc3571b19134a858756427593fb1b46
Autor:
Charles R. Lechner, Melanie A. McNally, Mark St. Pierre, Ryan J. Felling, Frances J. Northington, Carl E. Stafstrom, Raul Chavez-Valdez
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105222- (2021)
Since neonatal hypoxia-ischemia (HI) disrupts the hippocampal (Hp) GABAergic network in the mouse and Hp injury in this model correlates with flurothyl seizure susceptibility only in male mice, we hypothesized that GABAergic disruption correlates wit
Externí odkaz:
https://doaj.org/article/d9af2674c27c4db193326fb607f148ea
Autor:
Wolfgang Löscher, Carl E. Stafstrom
Publikováno v:
Epilepsia. 64:54-91
It is well established that epilepsy is associated with numerous neurobehavioral comorbidities, with a bidirectional relationship; people with epilepsy have an increased incidence of depression, anxiety, learning and memory difficulties, and numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc4d159ebfff6466212102311a3269c
https://doi.org/10.1111/epi.17433
https://doi.org/10.1111/epi.17433
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Current anti-seizure drugs (ASDs) are believed to reduce neuronal excitability through modulation of ion channels and transporters that regulate excitability at the synaptic level. While most patients with epilepsy respond to ASDs, many remain refrac
Externí odkaz:
https://doaj.org/article/c23e8b06acb24a82ad84c994106fc324
Publikováno v:
Journal of Neurophysiology.
Inhibition of glycolysis with 2-deoxyglucose (2-DG) produces anti-seizure effects in brain slices and animal models, yet the mechanisms remain elusive. Here, we examined two glycolysis-derived ATP-associated mechanisms: vacuole ATP pump (V-ATPase) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b959123936a73716dc1bc57ce5eb7a28
https://doi.org/10.1152/jn.00124.2023
https://doi.org/10.1152/jn.00124.2023
Autor:
William A. Schraegle, Rebecca F. Slomowitz, Carson Gundlach, David A. Hsu, Dace N. Almane, Carl E. Stafstrom, Michael Seidenberg, Jana E. Jones, Bruce P. Hermann
Publikováno v:
Epilepsia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea507e733d3505d52bbdd4e85121fd7
https://doi.org/10.1111/epi.17581
https://doi.org/10.1111/epi.17581
Autor:
Tomer Langberg, Ryan Dashek, Bernard Mulvey, Kimberly A. Miller, Susan Osting, Carl E. Stafstrom, Thomas P. Sutula
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 122-129 (2016)
Kindling is a phenomenon of activity-dependent neural circuit plasticity induced by repeated seizures that results in progressive permanent increases in susceptibility to epilepsy. As the permanent structural and functional modifications induced by k
Externí odkaz:
https://doaj.org/article/5c61608daa5c434c86823b7cd6f44eef