Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Carl Beyer"'
Autor:
L. Claisen
Publikováno v:
Berichte der deutschen chemischen Gesellschaft. 24:1117-1120
Autor:
Sylvia Musto, Arie Zask, Chuan Niu, Carolyn Discafani, Frank Loganzo, Tami Annable, Richard Hernandez, Emily B. Norton, Semiramis Ayral-Kaloustian, Carl Beyer, Ayako Yamashita, Joshua Kaplan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5317-5322
Analogs of hemiasterlin (1) and HTI-286 (2), which contain various aromatic rings in the A segment, were synthesized as potential inhibitors of tubulin polymerization. The structure-activity relationships related to stereo- and regio-chemical effects
Autor:
Richard Hernandez, Girija Krishnamurthy, Frank Loganzo, Arie Zask, Ayako Yamashita, Gary Harold Birnberg, Lee M. Greenberger, Zhilian Tang, Sylvia Musto, Tami Annable, Derek C. Cole, Xiaoran Yang, Robert Williamson, Semiramis Ayral-Kaloustian, Gulnaz Khafizova, Carolyn Discafani, Emily B. Norton, Katherine Cheung, Chuan Niu, Ronald Suayan, Joshua Kaplan, Carl Beyer
Publikováno v:
Journal of Medicinal Chemistry. 47:4774-4786
Hemiasterlin (1), a tripeptide isolated from marine sponges, induces microtubule depolymerization and mitotic arrest in cells. HTI-286 (2), an analogue from an initial study of the hemiasterlins, is presently in clinical trials. In addition to its po
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3003-3005
A series of 4-chloro-2-cyanoamino-6-fluoroalkylamino-5-phenylpyrimidines was prepared as a result of our efforts to modify a series of [1,2,4]triazolo[1,5-a]pyrimidines that proved to be potent anticancer agents with a unique mechanism of tubulin inh
Autor:
James Joseph Gibbons, Carl Beyer, Jay Afragola, Nguyen Thai Hiep, Judy Lucas, Richard Hernandez, Nan Zhang, Semiramis Ayral-Kaloustian
Publikováno v:
Journal of medicinal chemistry. 50(2)
The synthesis and SAR of a series of triazolopyrimidines as anticancer agents are described. Treatment of 5-chloro-6-(trifluorophenyl)-N-fluoroalkyl [1,2,4]triazolo[1,5-a]pyrimidin-7-amine with an alcohol, a thiol, or an alkylamine provided the corre
Autor:
Maria Tereza Nunes, Michael K. May, Frank Loganzo, Sylvia Musto, and Arie Zask, Malathi Hari, Albert A. Minnick, Celine Shi, Lee M. Greenberger, Yongchang Qiu, Joseph Wooters, Girija Krishnamurthy, Carl Beyer, Joshua Kaplan, Semiramis Ayral-Kaloustian
Publikováno v:
Biochemistry. 44(18)
A synthetic analogue of the tripeptide hemiasterlin, designated HTI-286, depolymerizes microtubules, is a poor substrate for P-glycoprotein, and inhibits the growth of paclitaxel-resistant tumors in xenograft models. Two radiolabeled photoaffinity an
Autor:
Arie, Zask, Gary, Birnberg, Katherine, Cheung, Joshua, Kaplan, Chuan, Niu, Emily, Norton, Ronald, Suayan, Ayako, Yamashita, Derek, Cole, Zhilian, Tang, Girija, Krishnamurthy, Robert, Williamson, Gulnaz, Khafizova, Sylvia, Musto, Richard, Hernandez, Tami, Annable, Xiaoran, Yang, Carolyn, Discafani, Carl, Beyer, Lee M, Greenberger, Frank, Loganzo, Semiramis, Ayral-Kaloustian
Publikováno v:
Journal of medicinal chemistry. 47(19)
Hemiasterlin, a tripeptide isolated from marine sponges, induces microtubule depolymerization and mitotic arrest in cells. HTI-286, an analogue from an initial study of the hemiasterlins, is presently in clinical trials. In addition to its potent ant
Autor:
Carl Beyer, Carolyn Discafani, Daniel Smith, Frank Loganzo, Semiramis Ayral-Kaloustian, Chuan Niu, Lee M. Greenberger, Arie Zask
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(16)
Modifications of the B-segment of HTI-286 (2) produced a class of analogs incorporating heteroatom-substituents. The structure-activity relationship was studied. Analogs bearing methylsulfide and fluoride groups exhibited potency comparable to that o
Autor:
Lee M. Greenberger, Frank Loganzo, Arie Zask, Chuan Niu, Ayako Yamashita, Semiramis Ayral-Kaloustian, Gary Harold Birnberg, Carl Beyer, Joshua Kaplan, Girija Krishnamurthy, Emily B. Norton, Katherine Cheung
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(16)
Modifications of the D-piece carboxylic acid group of the hemiasterlin analog HTI-286 gave tubulin inhibitors which were potent cytotoxic agents in taxol resistant cell lines expressing P-glycoprotein. Amides derived from proline had potency comparab
Autor:
Deepak, Sampath, Carolyn M, Discafani, Frank, Loganzo, Carl, Beyer, Hao, Liu, Xingzhi, Tan, Sylvia, Musto, Tami, Annable, Patricia, Gallagher, Carol, Rios, Lee M, Greenberger
Publikováno v:
Molecular cancer therapeutics. 2(9)
The taxanes, paclitaxel (PTX) and docetaxel (DTX), belong to a novel class of anticancer drugs that stabilize microtubules and lead to tumor cell death. While both agents are widely used for the treatment of lung, breast, and ovarian cancer, many tum