Zobrazeno 1 - 10
of 382
pro vyhledávání: '"Carl A. White"'
Autor:
Alla Gagarinova, Geordie Stewart, Bahram Samanfar, Sadhna Phanse, Carl A. White, Hiroyuki Aoki, Viktor Deineko, Natalia Beloglazova, Alexander F. Yakunin, Ashkan Golshani, Eric D. Brown, Mohan Babu, Andrew Emili
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 904-916 (2016)
Bacterial protein synthesis is an essential, conserved, and environmentally responsive process. Yet, many of its components and dependencies remain unidentified. To address this gap, we used quantitative synthetic genetic arrays to map functional rel
Externí odkaz:
https://doaj.org/article/dac41ea360a046c5a5f5850ed06d8be2
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 10, Iss 2, Pp 157-163 (2020)
The noxious effects from exposure to toxic inhalation hazards (TIHs, such as isocyanates, chlorine, etc.) are known to be triggered by the activation of transient receptor potential ankyrin 1 (TRPA1) ion channel. Antagonists of TRPA1 have shown near
Externí odkaz:
https://doaj.org/article/9de4eaf585314004bc9b5cac21a0c9ec
Autor:
Joëlle Goulding, Sarah J. Mistry, Mark Soave, Jeanette Woolard, Stephen J. Briddon, Carl W. White, Barrie Kellam, Stephen J. Hill
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Fluorescent ligand technologies have proved to be powerful tools to improve our understanding of ligand‐receptor interactions. Here we have characterized a small focused library of nine fluorescent ligands based on the highly selective β2
Externí odkaz:
https://doaj.org/article/2c5b98a025ee4151a930cc37503319ef
Autor:
Jelle van den Bor, Nick D. Bergkamp, Stephanie M. Anbuhl, Françoise Dekker, Dehan Comez, Claudia V. Perez Almeria, Reggie Bosma, Carl W. White, Laura E. Kilpatrick, Stephen J. Hill, Marco Siderius, Martine J. Smit, Raimond Heukers
Publikováno v:
Cell Rep Methods
Cell Reports Methods, 3(3):100422, 1-20. Cell Press
van den Bor, J, Bergkamp, N D, Anbuhl, S M, Dekker, F, Comez, D, Perez Almeria, C V, Bosma, R, White, C W, Kilpatrick, L E, Hill, S J, Siderius, M, Smit, M J & Heukers, R 2023, ' NanoB 2 to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET ', Cell Reports Methods, vol. 3, no. 3, 100422, pp. 1-20 . https://doi.org/10.1016/j.crmeth.2023.100422
Cell Reports Methods, 3(3):100422, 1-20. Cell Press
van den Bor, J, Bergkamp, N D, Anbuhl, S M, Dekker, F, Comez, D, Perez Almeria, C V, Bosma, R, White, C W, Kilpatrick, L E, Hill, S J, Siderius, M, Smit, M J & Heukers, R 2023, ' NanoB 2 to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET ', Cell Reports Methods, vol. 3, no. 3, 100422, pp. 1-20 . https://doi.org/10.1016/j.crmeth.2023.100422
The therapeutic potential of ligands targeting disease-associated membrane proteins is predicted by ligand-receptor binding constants, which can be determined using NanoLuciferase (NanoLuc)-based bioluminescence resonance energy transfer (NanoBRET) m
Publikováno v:
iScience, Vol 24, Iss 1, Pp 102011- (2021)
Summary: Secreted chemokines are critical mediators of cellular communication that elicit intracellular signaling by binding membrane-bound receptors. Here we demonstrate the development and use of a sensitive real-time approach to quantify secretion
Externí odkaz:
https://doaj.org/article/1719614ea1974a559fbe0eae3b96c904
Autor:
Daniel M. Hinds, Heidi J. Nick, Tessa M. Vallin, Leslie A. Bloomquist, Sarah Christeson, Preston E. Bratcher, Emily H. Cooper, John T. Brinton, Angela Bosco-Lauth, Carl W. White
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L525-L535
E-cigarette vaping is a major aspect of nicotine consumption, especially for children and young adults. Although it is branded as a safer alternative to cigarette smoking, murine and rat models of subacute and chronic e-cigarette vaping exposure have
Publikováno v:
GPCRs as Therapeutic Targets. :841-873
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Bioluminescence resonance energy transfer (BRET) has been a vital tool for understanding G protein-coupled receptor (GPCR) function. It has been used to investigate GPCR-protein and/or -ligand interactions as well as GPCR oligomerisation. Ho
Externí odkaz:
https://doaj.org/article/7b3fcf6037e049f69f6a0bb8d24be1b0
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Bioluminescence resonance energy transfer (BRET) is a biophysical technique used to monitor proximity within live cells. BRET exploits the naturally occurring phenomenon of dipole-dipole energy transfer from a donor enzyme (luciferase) to an acceptor
Externí odkaz:
https://doaj.org/article/af415a5501e44f34a985747f9c785f07
Autor:
George P. Philipopoulos, John Tat, Adriano Chan, Jingjing Jiang, David Mukai, Tanya Burney, Melody Doosty, Sari Mahon, Hemal H. Patel, Carl W. White, Matthew Brenner, Jangwoen Lee, Gerry R. Boss
Publikováno v:
Clinical toxicology (Philadelphia, Pa.), vol 60, iss 5
Clin Toxicol (Phila)
Clin Toxicol (Phila)
Methyl mercaptan (CH3SH) is a colorless, toxic gas with potential for occupational exposure and used as a weapon of mass destruction. Inhalation at high concentrations can result in dyspnea, hypoventilation, seizures, and death. No specific methyl me