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pro vyhledávání: '"Carl A. Lindmark"'
Autor:
Kerry Spear, Sripathy Venkatraman, Bingidimi I. Mobele, Cameron Gibb, Brian E. Marron, Grant Andrew Mcnaughton-Smith, Stephen M. Shaw, Mark J. Suto, Luckner Ulysse, Carl A. Lindmark
Publikováno v:
Organic Process Research & Development. 16:1385-1392
A scalable process for the manufacture of a potassium ion channel blocker was developed and optimized. Key features of the process include an optimized Grignard reaction, a direct cyanation of the intermediate trityl alcohol derivative, and an improv