Výsledky vyhledávání - "Carl A. Denard"

YESS 2.0, a Tunable Platform for Enzyme Evolution, Yields Highly Active TEV Protease Variants

Autor: Natalie McGinnis, Li Yi, Carl A Denard, George Georgiou, Chelsea J. Paresi, Rasha Yaghi, Zachary Bennett, Brent L. Iverson

Publikováno v: ACS Synthetic Biology. 10:63-71

Here we describe YESS 2.0, a highly versatile version of the yeast endoplasmic sequestration screening (YESS) system suitable for engineering and characterizing protein/peptide modifying enzymes such as proteases with desired new activities. By incor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e961e55a4348203cb3d929bd5e468b
https://doi.org/10.1021/acssynbio.0c00452

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Combining Rh-Catalyzed Diazocoupling and Enzymatic Reduction To Efficiently Synthesize Enantioenriched 2-Substituted Succinate Derivatives

Autor: Yajie Wang, Huimin Zhao, Mark J. Bartlett, John F. Hartwig, Carl A. Denard

Publikováno v: ACS Catalysis. 7:2548-2552

We report the development of a modular, one-pot, sequential chemoenzymatic system for the formal enantioselective construction of the C–C bond in 2-aryl 1,4-dicarbonyl compounds. This sequence comprises a rhodium-catalyzed diazocoupling that provid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfc15a21212b9a189b167b8556642c68
https://doi.org/10.1021/acscatal.7b00254

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Development of a One-Pot Tandem Reaction Combining Ruthenium-Catalyzed Alkene Metathesis and Enantioselective Enzymatic Oxidation To Produce Aryl Epoxides

Autor: Carl A. Denard, Huimin Zhao, Mark J. Bartlett, John F. Hartwig, Yajie Wang, Lu Lu

Publikováno v: ACS Catalysis. 5:3817-3822

We report the development of a tandem chemoenzymatic transformation that combines alkene metathesis with enzymatic epoxidation to provide aryl epoxides. The development of this one-pot reaction required substantial protein and reaction engineering to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::986a70c976e0c9217ac82261932efd68
https://doi.org/10.1021/acscatal.5b00533

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Improving and repurposing biocatalysts via directed evolution

Autor: Carl A. Denard, Huimin Zhao, Hengqian Ren

Publikováno v: Current Opinion in Chemical Biology. 25:55-64

Over the last two decades, directed evolution has become a staple in protein engineering and ushered in a new era of industrial biocatalysis. Directed evolution has provided the tools to not only improve the activity of known biocatalysts, but also t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcc878cd0193a942fcd8c8bac283101
https://doi.org/10.1016/j.cbpa.2014.12.036

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Tandem Catalytic Conversion of Glucose to 5-Hydroxymethylfurfural with an Immobilized Enzyme and a Solid Acid

Autor: James A. Dumesic, Carl A. Denard, Susannah L. Scott, Anthony J. Crisci, Huimin Zhao, Yu Run Miao, Ricardo Alamillo, Hua Huang

Publikováno v: ACS Catalysis. 4:2165-2168

Conversion of cellulosic biomass to renewable chemicals such as 5-hydroxymethylfurfural (HMF) is of high current interest. Herein, we report a rare example of one-pot synthesis of HMF from glucose by tandem catalysis. The system is composed of a ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5f72fb4fe48f35092cb25fbdd74b402
https://doi.org/10.1021/cs500591f

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Cooperative Tandem Catalysis by an Organometallic Complex and a Metalloenzyme

Autor: Hua Huang, Yichen Tan, Carl A. Denard, Mark J. Bartlett, Huimin Zhao, John F. Hartwig, Lu Lu

Publikováno v: Angewandte Chemie International Edition. 53:465-469

Although chemical and enzymatic catalysts have been combined, reactions in which an organometallic catalyst and a metalloenzyme work cooperatively to create products, which cannot be generated with either catalyst alone or in comparable yields by seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f6d38afa1d405b635b66aca61c1bbf
https://doi.org/10.1002/anie.201305778

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Multistep One-Pot Reactions Combining Biocatalysts and Chemical Catalysts for Asymmetric Synthesis

Autor: John F. Hartwig, Carl A. Denard, Huimin Zhao

Publikováno v: ACS Catalysis. 3:2856-2864

In a continuous effort to emulate the efficiency of biosynthetic pathways, considerable progress has been made in developing one-pot chemoenzymatic processes that take full advantage of the chemo-, regio-, and stereoselectivity of biocatalysts and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::605498b0c83fd9ad7f53e091bb8029e7
https://doi.org/10.1021/cs400633a

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Engineering of Enzymes for Selective Catalysis

Autor: Nikhil U. Nair, Carl A. Denard, Huimin Zhao

Publikováno v: Current Organic Chemistry. 14:1870-1882

Naturally occurring enzymes are truly remarkable catalysts. However, many are not suitable for practical synthetic chemistry because of poor substrate or product selectivity. This review highlights recent advances in engineering enzymes for selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebcf59a9e806b2bf1bed301a3c446580
https://doi.org/10.2174/138527210792927537

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