Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Carl A Morrow"'
Autor:
Sanjeeta Tamang, Anastasiya Kishkevich, Carl A Morrow, Fekret Osman, Manisha Jalan, Matthew C Whitby
Publikováno v:
eLife, Vol 8 (2019)
Protein-DNA complexes can impede DNA replication and cause replication fork collapse. Whilst it is known that homologous recombination is deployed in such instances to restart replication, it is unclear how a stalled fork transitions into a collapsed
Externí odkaz:
https://doaj.org/article/030f2a55c4334ce38e943f6381596004
Publikováno v:
eLife, Vol 8 (2019)
Homologous recombination helps ensure the timely completion of genome duplication by restarting collapsed replication forks. However, this beneficial function is not without risk as replication restarted by homologous recombination is prone to templa
Externí odkaz:
https://doaj.org/article/27e0a765027c43da9c263194a864bd06
Autor:
Carl A Morrow, Michael O Nguyen, Andrew Fower, Io Nam Wong, Fekret Osman, Claire Bryer, Matthew C Whitby
Publikováno v:
eLife, Vol 6 (2017)
Problems that arise during DNA replication can drive genomic alterations that are instrumental in the development of cancers and many human genetic disorders. Replication fork barriers are a commonly encountered problem, which can cause fork collapse
Externí odkaz:
https://doaj.org/article/b8951f8da06942ba86586b4199bd28af
Publikováno v:
eLife, Vol 4 (2015)
The completion of genome duplication during the cell cycle is threatened by the presence of replication fork barriers (RFBs). Following collision with a RFB, replication proteins can dissociate from the stalled fork (fork collapse) rendering it incap
Externí odkaz:
https://doaj.org/article/9d01ab00b55344b6a51f07e2d0c7d1bc
Autor:
I Russel Lee, Liting Yang, Gaseene Sebetso, Rebecca Allen, Thi H N Doan, Ross Blundell, Edmund Y L Lui, Carl A Morrow, James A Fraser
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64292 (2013)
Degradation of purines to uric acid is generally conserved among organisms, however, the end product of uric acid degradation varies from species to species depending on the presence of active catabolic enzymes. In humans, most higher primates and bi
Externí odkaz:
https://doaj.org/article/a53d16f2bfc6468f9f5bf863f9ab9025
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Replication fork stalling can provoke fork reversal to form a four-way DNA junction. This remodelling of the replication fork can facilitate repair, aid bypass of DNA lesions, and enable replication restart, but may also pose a risk of over-
Externí odkaz:
https://doaj.org/article/3f29fa79d51a4f2aadffb1c1d3c8e554
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32585 (2012)
Nitrogen source utilization plays a critical role in fungal development, secondary metabolite production and pathogenesis. In both the Ascomycota and Basidiomycota, GATA transcription factors globally activate the expression of catabolic enzyme-encod
Externí odkaz:
https://doaj.org/article/3d3517c6d7434856947ca9f070997509
Autor:
Carl A Morrow, Eugene Valkov, Anna Stamp, Eve W L Chow, I Russel Lee, Ania Wronski, Simon J Williams, Justine M Hill, Julianne T Djordjevic, Ulrike Kappler, Bostjan Kobe, James A Fraser
Publikováno v:
PLoS Pathogens, Vol 8, Iss 10, p e1002957 (2012)
We have investigated the potential of the GTP synthesis pathways as chemotherapeutic targets in the human pathogen Cryptococcus neoformans, a common cause of fatal fungal meningoencephalitis. We find that de novo GTP biosynthesis, but not the alterna
Externí odkaz:
https://doaj.org/article/33cc5f6ca2e241689d79d1cbab96ad8a
Autor:
Anastasiya Kishkevich, Sanjeeta Tamang, Michael O. Nguyen, Judith Oehler, Elena Bulmaga, Christos Andreadis, Carl A. Morrow, Manisha Jalan, Fekret Osman, Matthew C. Whitby
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The restart of collapsed replication forks is associated with high rates of genomic rearrangement. Here, the authors show that during restart initiation rearrangements are driven mainly by Rad51, whereas during elongation they rely more on Rad52.
Externí odkaz:
https://doaj.org/article/6a64dad8bca9428f9e4b9302bfe9df56
Autor:
Anastasiya Kishkevich, Sanjeeta Tamang, Michael O. Nguyen, Judith Oehler, Elena Bulmaga, Christos Andreadis, Carl A. Morrow, Manisha Jalan, Fekret Osman, Matthew C. Whitby
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/abb0f0ab0d7247ee9dcb9be8c37206ec