Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Carl A Melbourne"'
Autor:
Carl A. Melbourne, A. Mesut Erzurumluoglu, Nick Shrine, Jing Chen, Martin D. Tobin, Anna L. Hansell, Louise V. Wain
Publikováno v:
Environment International, Vol 159, Iss , Pp 107041- (2022)
Background: Impaired lung function is predictive of mortality and is a key component of chronic obstructive pulmonary disease. Lung function has a strong genetic component but is also affected by environmental factors such as increased exposure to ai
Externí odkaz:
https://doaj.org/article/b14deca42ad645fa964b9fbb21249d4c
Autor:
John E. Hokanson, Nick Shrine, Brian D. Hobbs, Dmitry Prokopenko, Carl A. Melbourne, Edwin K. Silverman, Sharon M. Lutz, Louise V. Wain, Martin D. Tobin, Woori Kim, Phuwanat Sakornsakolpat, Terri H. Beaty, Michael H. Cho
Publikováno v:
Am J Epidemiol
Risk of chronic obstructive pulmonary disease (COPD) is determined by both cigarette smoking and genetic susceptibility, but little is known about gene-by-smoking interactions. We performed a genome-wide association analysis of 179,689 controls and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ad5cf651f8c6d1007a37af13fe27ce
https://doi.org/10.1093/aje/kwaa227
https://doi.org/10.1093/aje/kwaa227
Autor:
Carl A Melbourne, Anna L Guyatt, Laura Nellums, Padmasayee Papineni, Amit Gupta, Irtiza Qureshi, Christopher A Martin, Luke Bryant, Catherine John, Mayuri Gogoi, Fatimah Wobi, Amani Al-Oraibi, Jonathan Chaloner, Avinash Aujayeb, Bindu Gregary, Susie Lagrata, Rubina Reza, Sandra Simpson, Stephen Zingwe, Martin Tobin, Sue Carr, Kamlesh Khunti, Laura J Gray, I Chris McManus, Katherine Woolf, Manish Pareek
ObjectivesTo investigate how ethnicity and other sociodemographic, work, and physical health factors are related to mental health in UK healthcare and ancillary workers (HCWs), and how structural inequities in these factors may contribute to differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::086829e86d6585b52a48beaa865a7ee6
https://doi.org/10.1101/2022.02.03.22270306
https://doi.org/10.1101/2022.02.03.22270306
Autor:
Kamlesh Khunti, Katherine Woolf, Avinash Aujayeb, Daniel Pan, Carl A. Melbourne, Sue Carr, Alan Gopal, Rubina Reza, Anna L. Guyatt, Manish Pareek, Laura B Nellums, Bindu Gregary, Laura J. Gray, Sandra Simpson, Stephen Zingwe, Martin D. Tobin, Thomas Hine, Amit Gupta, Catherine John, Joshua Nazareth, Christopher A Martin, I. C. McManus, Luke Bryant
ObjectivesTo determine the prevalence and predictors of self-reported access to appropriate personal protective equipment (aPPE) for healthcare workers (HCWs) in the United Kingdom (UK) during the first UK national COVID-19 lockdown (March 2020) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a490ab9637656e4dd5c6eadd2afb6cf
https://doi.org/10.1101/2021.09.16.21263629
https://doi.org/10.1101/2021.09.16.21263629
Autor:
Anna Hansell, Chen J, Nick Shrine, Tobin, Louise V. Wain, Erzurumluoglu Am, Carl A. Melbourne
Impaired lung function is predictive of mortality and is a key component in the diagnosis of chronic obstructive pulmonary disease. Lung function has a strong genetic component but is also affected by environmental factors such as increased exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4deda36f062fd5d990b6b1eddcf575a
https://doi.org/10.1101/2021.06.03.21256376
https://doi.org/10.1101/2021.06.03.21256376
Autor:
Lucy Teece, David A. McAllister, Martin D. Tobin, Kamlesh Khunti, Keith R. Abrams, Manish Pareek, Catherine John, Christopher Orton, David V. Ford, Laura J. Gray, Christopher A Martin, Carl A. Melbourne
Publikováno v:
BMJ Open, Vol 11, Iss 6 (2021)
BMJ Open
BMJ Open
IntroductionCOVID-19 has spread rapidly worldwide, causing significant morbidity and mortality. People from ethnic minorities, particularly those working in healthcare settings, have been disproportionately affected. Current evidence of the associati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe6991b6391c7ae4f273e690a2f3e75
https://bmjopen.bmj.com/content/11/6/e046392.full
https://bmjopen.bmj.com/content/11/6/e046392.full
Autor:
Phuwanat Sakornsakolpat, James F. Wilson, María Soler Artigas, Beate Stubbe, Nicholas J. Wareham, James D. Crapo, Victoria E. Jackson, Eleftheria Zeggini, Olga G. Troyanskaya, Medea Imboden, A. Mesut Erzurumluoglu, Adam S. Butterworth, Carl A. Melbourne, Ian Sayers, Lars Lind, Stefan Weiss, Margaret M. Parker, Timmers Prhj, Edwin K. Silverman, John C. Whittaker, Ian P. Hall, Ozren Polasek, Mika Kähönen, Katherine A. Fawcett, Anna Hansell, Liming Li, David J. Porteous, Louise V. Wain, Robert A. Scott, Richard Packer, Richard J. Allen, Robin G Walters, Anna L. Guyatt, Terho Lehtimäki, Nicole Probst-Hensch, Shona M. Kerr, Christian Gieger, Matthias Wielscher, Rajesh Rawal, Jing Hua Zhao, John E. Hokanson, Holger Schulz, Nicola F. Reeve, Claudia Langenberg, Ke Hao, Corry-Anke Brandsma, Megan L. Paynton, Vitart, Dmitry Prokopenko, Jennie Hui, Eugene R. Bleecker, Ma'en Obeidat, John Danesh, Ralf Ewert, Benjamin B. Sun, Frank Dudbridge, Jian Zhou, Brian D. Hobbs, Blair H. Smith, Don D. Sin, Dawn L. DeMeo, Joseph C. Maranville, Ida Surakka, Alison Catherine Murray, Nicholas Locantore, Katherine A. Kentistou, Terri H. Beaty, Igor Rudan, Kuang Lin, Amund Gulsvik, Ian J. Deary, Ruth Tal-Singer, Kijoung Song, David C. Nickle, Michael H. Cho, Jian'an Luan, Joshua D. Hoffman, Georg Homuth, Zhengming Chen, Dandi Qiao, Heiko Runz, Per Bakke, Chiara Batini, Caroline Hayward, Stefan Karrasch, Alan James, Andrew P. Morris, Prescott G. Woodruff, Laura M Yerges Armstrong, David Sparrow, Ulf Gyllensten, James P. Cook, Jonathan Marten, Olli T. Raitakari, Nick Shrine, Deborah A. Meyers, Tobin, Ruth Boxall, Marjo-Riitta Järvelin, David P. Strachan, Sarah E. Harris, Philippe Joubert, Stefan Enroth, Xingnan Li, van den Berge M, Anubha Mahajan, Yohan Bossé, Peter K. Joshi
Publikováno v:
Nature genetics
Nat. Genet. 51, 481-493 (2019)
Shrine, N R G, Guyatt, A, Erzurumluoglu, A M, Jackson, V E, Hobbs, B D, Melbourne, C, Batini, C, Fawcett, K A, Song, K, Sakornsakolpat, P, Li, X, Boxall, R, Reeve, N F, Obeidat, M, Zhao, J H, Wielscher, M, Weiss, S, Kentistou, K, Cook, J P, Sun, B B, Zhou, J, Hui, J, Karrasch, S, Imboden, M, Harris, S, Marten, J, Enroth, S, Kerr, S, Surakka, I, Vitart, V, Lehtimäki, T, Allen, R J, Bakke, P S, Beaty, T H, Bleecker, E R, Bossé, Y, Brandsma, C-A, Chen, Z, Crapo, J D, Danesh, J, Demeo, D L, Dudbridge, F, Ewert, R, Gieger, C, Gulsvik, A, Hansell, A L, Hao, K, Hoffman, J D, Hokanson, J E, Homuth, G, Joshi, P, Joubert, P, Langenberg, C, Li, X, Li, L, Lin, K, Lind, L, Locantore, N, Luan, J, Mahajan, A, Maranville, J C, Murray, A, Nickle, D C, Packer, R, Parker, M M, Paynton, M L, Porteous, D, Prokopenko, D, Qiao, D, Rawal, R, Runz, H, Sayers, I, Sin, D D, Smith, B H, Soler Artigas, M, Sparrow, D, Tal-Singer, R, Timmers, P RHJ, van den Berge, M, Woodruff, P G, Yerges-Armstrong, L M, Troyanskaya, O G, Raitakar, O, Kähönen, M, Polasek, O, Rudan, I, Deary, I, Probst-Hensch, N M, Schulz, H, James, A L, Wilson, J F, Stubbe, B, Zeggini, E, Jarvelin, M-R, Wareham, N, Silverman, E K, Hayward, C, Morris, A P, Butterworth, A S, Scott, R A, Walters, R G, Meyers, D A, Cho, M H, Strachan, D P, Hall, I P & Tobin, M D & Wain, L V 2019, ' New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, pp. 481–493 . https://doi.org/10.1038/s41588-018-0321-7
NATURE GENETICS
Understanding Society Scientific Group 2019, ' New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, no. 3, pp. 481-493 . https://doi.org/10.1038/s41588-018-0321-7
Nature Genetics, 51(3), 481-493. Nature Publishing Group
Nat. Genet. 51, 481-493 (2019)
Shrine, N R G, Guyatt, A, Erzurumluoglu, A M, Jackson, V E, Hobbs, B D, Melbourne, C, Batini, C, Fawcett, K A, Song, K, Sakornsakolpat, P, Li, X, Boxall, R, Reeve, N F, Obeidat, M, Zhao, J H, Wielscher, M, Weiss, S, Kentistou, K, Cook, J P, Sun, B B, Zhou, J, Hui, J, Karrasch, S, Imboden, M, Harris, S, Marten, J, Enroth, S, Kerr, S, Surakka, I, Vitart, V, Lehtimäki, T, Allen, R J, Bakke, P S, Beaty, T H, Bleecker, E R, Bossé, Y, Brandsma, C-A, Chen, Z, Crapo, J D, Danesh, J, Demeo, D L, Dudbridge, F, Ewert, R, Gieger, C, Gulsvik, A, Hansell, A L, Hao, K, Hoffman, J D, Hokanson, J E, Homuth, G, Joshi, P, Joubert, P, Langenberg, C, Li, X, Li, L, Lin, K, Lind, L, Locantore, N, Luan, J, Mahajan, A, Maranville, J C, Murray, A, Nickle, D C, Packer, R, Parker, M M, Paynton, M L, Porteous, D, Prokopenko, D, Qiao, D, Rawal, R, Runz, H, Sayers, I, Sin, D D, Smith, B H, Soler Artigas, M, Sparrow, D, Tal-Singer, R, Timmers, P RHJ, van den Berge, M, Woodruff, P G, Yerges-Armstrong, L M, Troyanskaya, O G, Raitakar, O, Kähönen, M, Polasek, O, Rudan, I, Deary, I, Probst-Hensch, N M, Schulz, H, James, A L, Wilson, J F, Stubbe, B, Zeggini, E, Jarvelin, M-R, Wareham, N, Silverman, E K, Hayward, C, Morris, A P, Butterworth, A S, Scott, R A, Walters, R G, Meyers, D A, Cho, M H, Strachan, D P, Hall, I P & Tobin, M D & Wain, L V 2019, ' New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, pp. 481–493 . https://doi.org/10.1038/s41588-018-0321-7
NATURE GENETICS
Understanding Society Scientific Group 2019, ' New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries ', Nature Genetics, vol. 51, no. 3, pp. 481-493 . https://doi.org/10.1038/s41588-018-0321-7
Nature Genetics, 51(3), 481-493. Nature Publishing Group
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3456e2384a4251ad8956ff4aa355ecc3
http://europepmc.org/articles/PMC6397078
http://europepmc.org/articles/PMC6397078
Autor:
Carl A. Melbourne, Caroline Hayward, Stefan Karrasch, Dirk Keidel, Katherine A. Fawcett, Susan M. Ring, Yohan Bossé, Carol A. Wang, Ben Michael Brumpton, Claudia Langenberg, Peter K. Joshi, Ke Hao, Igor Rudan, David J. Porteous, Don D. Sin, Raquel Granell, Blair H. Smith, Jian'an Luan, Kristian Hveem, Sarah E. Harris, Sandosh Padmanabhan, Archie Campbell, Sebastian May-Wilson, Veronique Vitart, Nicola Pirastu, Arnulf Langhammer, Craig E. Pennell, John M. Starr, Stefan Weiss, Karina Patasova, Nicholas J. Wareham, James F. Wilson, Deborah Jarvis, Tim D. Spector, Nick Shrine, David P. Strachan, Martin D. Tobin, Beate Stubbe, David M. Evans, Kirsi H. Pietiläinen, Mangino Massimo, Ian P. Hall, Graham L. Hall, Jaakko Kaprio, Ralf Ewert, Rachel E. Foong, Claudia Flexeder, Louise V. Wain, Ma'en Obeidat, Cristen J. Willer, Leo-Pekka Lyytikäinen, Olli T. Raitakari, John Henderson, Konstantin Strauch, Marta R Moksnes, Cosetta Minelli, Nicole Probst-Hensch, Pirro G. Hysi, Anna L. Guyatt, Henry Völzke, Thomas Meitinger, Peter D. Sly, Ozren Polasek, Anne Richmond, Mika Kähönen, Maarten van den Berge, Medea Imboden, Thibaud Boutin, Lucija Klaric, Laura Portas, Terho Lehtimäki, Ian J. Deary, Taina Rantanen, Catherine John, Teemu Palviainen
Publikováno v:
Fawcett, K, Granell, R & Wain, L V 2021, ' Variants associated with HHIP expression have sex-differential effects on lung function ', Wellcome Open Research, vol. 5, pp. 1-20 . https://doi.org/10.12688/WELLCOMEOPENRES.15846.2
Wellcome open research, 5:111
Wellcome Open Research
Fawcett, K A, Obeidat, M, Melbourne, C, Shrine, N, Guyatt, A L, John, C, Luan, J, Richmond, A, Moksnes, M R, Granell, R, Weiss, S, Imboden, M, May-Wilson, S, Hysi, P, Boutin, T S, Portas, L, Flexeder, C, Harris, S E, Wang, C A, Lyytikäinen, L P, Palviainen, T, Foong, R E, Keidel, D, Minelli, C, Langenberg, C, Bossé, Y, Berge, M V D, Sin, D D, Hao, K, Campbell, A, Porteous, D, Padmanabhan, S, Smith, B H, Evans, D M, Ring, S, Langhammer, A, Hveem, K, Willer, C, Ewert, R, Stubbe, B, Pirastu, N, Klaric, L, Joshi, P K, Patasova, K, Massimo, M, Polasek, O, Starr, J M, Karrasch, S, Strauch, K, Meitinger, T, Rudan, I, Rantanen, T, Pietiläinen, K, Kähönen, M, Raitakari, O T, Hall, G L, Sly, P D, Pennell, C E, Kaprio, J, Lehtimäki, T, Vitart, V, Deary, I J, Jarvis, D, Wilson, J F, Spector, T, Probst-Hensch, N, Wareham, N J, Völzke, H, Henderson, J, Strachan, D P, Brumpton, B M, Hayward, C, Hall, I P, Tobin, M D & Wain, L V 2021, ' Variants associated with HHIP expression have sexdifferential effects on lung function ', Wellcome Open Research, vol. 5, pp. 1-20 . https://doi.org/10.12688/WELLCOMEOPENRES.15846.2
Wellcome Open Res. 5:111 (2021)
Fawcett, K A, Obeidat, M, Melbourne, C, Shrine, N, Guyatt, A L, John, C, Luan, J, Richmond, A, Moksnes, M R, Granell, R, Weiss, S, Imboden, M, May-wilson, S, Hysi, P, Boutin, T S, Portas, L, Flexeder, C, Harris, S E, Wang, C A, Lyytikäinen, L, Palviainen, T, Foong, R E, Keidel, D, Minelli, C, Langenberg, C, Bossé, Y, Van Den Berge, M, Sin, D D, Hao, K, Campbell, A, Porteous, D, Padmanabhan, S, Smith, B H, Evans, D M, Ring, S, Langhammer, A, Hveem, K, Willer, C, Ewert, R, Stubbe, B, Pirastu, N, Klaric, L, Joshi, P K, Patasova, K, Massimo, M, Polasek, O, Starr, J M, Karrasch, S, Strauch, K, Meitinger, T, Rudan, I, Rantanen, T, Pietiläinen, K, Kähönen, M, Raitakari, O T, Hall, G L, Sly, P D, Pennell, C E, Kaprio, J, Lehtimäki, T, Vitart, V, Deary, I J, Jarvis, D, Wilson, J F, Spector, T, Probst-hensch, N, Wareham, N J, Völzke, H, Henderson, J, Strachan, D P, Brumpton, B M, Hayward, C, Hall, I P, Tobin, M D & Wain, L V 2021, ' Variants associated with HHIP expression have sex-differential effects on lung function ', Wellcome Open Research, vol. 5, pp. 111 . https://doi.org/10.12688/wellcomeopenres.15846.1
Wellcome open research, 5:111
Wellcome Open Research
Fawcett, K A, Obeidat, M, Melbourne, C, Shrine, N, Guyatt, A L, John, C, Luan, J, Richmond, A, Moksnes, M R, Granell, R, Weiss, S, Imboden, M, May-Wilson, S, Hysi, P, Boutin, T S, Portas, L, Flexeder, C, Harris, S E, Wang, C A, Lyytikäinen, L P, Palviainen, T, Foong, R E, Keidel, D, Minelli, C, Langenberg, C, Bossé, Y, Berge, M V D, Sin, D D, Hao, K, Campbell, A, Porteous, D, Padmanabhan, S, Smith, B H, Evans, D M, Ring, S, Langhammer, A, Hveem, K, Willer, C, Ewert, R, Stubbe, B, Pirastu, N, Klaric, L, Joshi, P K, Patasova, K, Massimo, M, Polasek, O, Starr, J M, Karrasch, S, Strauch, K, Meitinger, T, Rudan, I, Rantanen, T, Pietiläinen, K, Kähönen, M, Raitakari, O T, Hall, G L, Sly, P D, Pennell, C E, Kaprio, J, Lehtimäki, T, Vitart, V, Deary, I J, Jarvis, D, Wilson, J F, Spector, T, Probst-Hensch, N, Wareham, N J, Völzke, H, Henderson, J, Strachan, D P, Brumpton, B M, Hayward, C, Hall, I P, Tobin, M D & Wain, L V 2021, ' Variants associated with HHIP expression have sexdifferential effects on lung function ', Wellcome Open Research, vol. 5, pp. 1-20 . https://doi.org/10.12688/WELLCOMEOPENRES.15846.2
Wellcome Open Res. 5:111 (2021)
Fawcett, K A, Obeidat, M, Melbourne, C, Shrine, N, Guyatt, A L, John, C, Luan, J, Richmond, A, Moksnes, M R, Granell, R, Weiss, S, Imboden, M, May-wilson, S, Hysi, P, Boutin, T S, Portas, L, Flexeder, C, Harris, S E, Wang, C A, Lyytikäinen, L, Palviainen, T, Foong, R E, Keidel, D, Minelli, C, Langenberg, C, Bossé, Y, Van Den Berge, M, Sin, D D, Hao, K, Campbell, A, Porteous, D, Padmanabhan, S, Smith, B H, Evans, D M, Ring, S, Langhammer, A, Hveem, K, Willer, C, Ewert, R, Stubbe, B, Pirastu, N, Klaric, L, Joshi, P K, Patasova, K, Massimo, M, Polasek, O, Starr, J M, Karrasch, S, Strauch, K, Meitinger, T, Rudan, I, Rantanen, T, Pietiläinen, K, Kähönen, M, Raitakari, O T, Hall, G L, Sly, P D, Pennell, C E, Kaprio, J, Lehtimäki, T, Vitart, V, Deary, I J, Jarvis, D, Wilson, J F, Spector, T, Probst-hensch, N, Wareham, N J, Völzke, H, Henderson, J, Strachan, D P, Brumpton, B M, Hayward, C, Hall, I P, Tobin, M D & Wain, L V 2021, ' Variants associated with HHIP expression have sex-differential effects on lung function ', Wellcome Open Research, vol. 5, pp. 111 . https://doi.org/10.12688/wellcomeopenres.15846.1
Background: Lung function is highly heritable and differs between the sexes throughout life. However, little is known about sex-differential genetic effects on lung function. We aimed to conduct the first genome-wide genotype-by-sex interaction study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312f5db945545c66e6f18c62faf6290c
https://research-information.bris.ac.uk/ws/files/287782046/3fa30dd5_3d84_4cd9_880c_57cb63dda7c6_15846_katherine_fawcett_v2.pdf
https://research-information.bris.ac.uk/ws/files/287782046/3fa30dd5_3d84_4cd9_880c_57cb63dda7c6_15846_katherine_fawcett_v2.pdf
Autor:
Paul H. Lee, Anna L. Guyatt, Catherine John, Altaf Ali, Xueyang Wang, Alexander T. Williams, Bo Zhao, Chiara Batini, Catherine Bee, Emma Adams, Carl A. Melbourne, Christopher E. Brightling, Ron Hsu, Jane Bethea, Nicola Reeve, Ioanna Ntalla, Sarah Terry, Manish Pareek, Nigel J. Brunskill, Julian Barwell, Edward J. Hollox, Jose Miola, Susan E. Wallace, David J. Shepherd, Richard Packer, Laura Venn, Louise V. Wain, Robert C. Free, Martin D. Tobin
Publikováno v:
Wellcome Open Research. 6:349
Background: New data collection in established longitudinal population studies provides an opportunity for studying the risk factors and sequelae of the novel coronavirus disease 2019 (COVID-19), plus the indirect impacts of the COVID-19 pandemic on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::defec9f0622e2925ae7413c573b47db0
https://doi.org/10.12688/wellcomeopenres.17437.1
https://doi.org/10.12688/wellcomeopenres.17437.1
Autor:
Anna Hansell, Louise V. Wain, Dany Doiron, Carl A. Melbourne, Kees de Hoogh, Martin D. Tobin, A. Mesut Erzurumluoglu
Publikováno v:
Genes and environment.
Air pollution has been found to be associated with reduced lung function; also 279 genetic signals of association with lung function have been identified that implicate multiple genes and pathways. In this study, we examined if any of these signals i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3831772a1944243bb8fe2cc2cb22b1be
https://doi.org/10.1183/13993003.congress-2019.pa5395
https://doi.org/10.1183/13993003.congress-2019.pa5395