Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Carl Saint-Louis"'
Autor:
Nadia Fortin, Carl Saint-Louis, Annick Landry, René Gagnon, Gilles Olsen, Sylvain Bernard, Patrick Bherer, Eric Marsault, Véronique Plourde, Gilles Berthiaume, Martin Brassard, Robert Deziel, Axel Mathieu, Gérald Villeneuve, Xiaowen Peng, Hamid R. Hoveyda, Mark Peterson, Graeme L. Fraser, François Bilodeau, Ruoxi Lan, Shridhar Bhat, Annie Doucet, Maude Gauthier, Yves L. Dory, David Lonergan, Shigui Li, Sylvie Beaubien, Luc Ouellet, Pierre Deslongchamps, Alexandre Drouin, Fabrice Galaud, Sophie Beauchemin, Manon Champagne, Kamel Benakli, Mahesh Ramaseshan, Laurence Foucher, Jean François Pinault, Martin Vezina, Daniel Fortin, Zhigang Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4731-4735
A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf941f5cc5a05130451a2464ff661573
https://doi.org/10.1016/j.bmcl.2008.06.085
https://doi.org/10.1016/j.bmcl.2008.06.085
Autor:
Eric Marsault, Kamel Benakli, Graeme L. Fraser, Annick Landry, Sophie Beauchemin, Mahesh Ramaseshan, Laurence Foucher, Xiaowen Peng, Jean François Pinault, Martin Brassard, Daniel F. Veber, Martin Vezina, René Gagnon, Shridhar Bhat, Hamid R. Hoveyda, Carl Saint-Louis, Mark Peterson, Patrick Bherer, Sylvie Beaubien, Axel Mathieu, Luc Ouellet, Zhigang Wang
Publikováno v:
Journal of medicinal chemistry. 54(24)
High-throughput screening of Tranzyme Pharma's proprietary macrocycle library using the aequorin Ca2+-bioluminescence assay against the human ghrelin receptor (GRLN) led to the discovery of novel agonists against this G-protein coupled receptor. Earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d338a7eaed3c1a1e5dec403cfa4d2f29
https://pubmed.ncbi.nlm.nih.gov/22106937
https://pubmed.ncbi.nlm.nih.gov/22106937
Autor:
Kamel Benakli, Eric Marsault, Graeme L. Fraser, Robert Deziel, Carl Saint-Louis, Sylvie Beaubien
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
Novel, potent small molecule motilin receptor antagonists are described. These peptidomimetic macrocycles are composed of a tripeptide cyclized backbone-to-backbone with a nonpeptidic tether and bear new unnatural amino acids containing basic side ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc292fb16a1ce94eb62175be731b474
https://pubmed.ncbi.nlm.nih.gov/17533127
https://pubmed.ncbi.nlm.nih.gov/17533127
Autor:
Hamid R. Hoveyda, Carl Saint-Louis, Theo Peeters, Zhigang Wang, Martin Vezina, Robert Deziel, Graeme L. Fraser, Sylvie Beaubien, Annick Landry, Luc Ouellet, Eric Marsault, Mark Peterson, Sophie Beauchemin, Mahesh Ramaseshan, Kamel Benakli
Publikováno v:
Journal of medicinal chemistry. 49(24)
A novel class of macrocyclic peptidomimetics was identified and optimized as potent antagonists to the human motilin receptor (hMOT-R). Well-defined structure-activity relationships allowed for rapid optimization of potency that eventually led to hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935ca7584da8bbf469dd5fe442847841
https://pubmed.ncbi.nlm.nih.gov/17125271
https://pubmed.ncbi.nlm.nih.gov/17125271
Autor:
Hamid R. Hoveyda, Eric Marsault, ReneÌ Gagnon, Axel P. Mathieu, Martin VeÌzina, Annick Landry, Zhigang Wang, Kamel Benakli, Sylvie Beaubien, Carl Saint-Louis, Martin Brassard, Jean-François Pinault, Luc Ouellet, Shridhar Bhat, Mahesh Ramaseshan, Xiaowen Peng, Laurence Foucher, Sophie Beauchemin, Patrick BheÌrer, Daniel F. Veber
Publikováno v:
Journal of Medicinal Chemistry; Dec2011, Vol. 54 Issue 24, p8305-8320, 16p