Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Carl, Ng"'
Autor:
Aimee Fourie-O’Donohue, Phillip Y. Chu, Josefa dela Cruz Chuh, Robert Tchelepi, Siao Ping Tsai, John C. Tran, William S. Sawyer, Dian Su, Carl Ng, Keyang Xu, Shang-Fan Yu, Thomas H. Pillow, Jack Sadowsky, Peter S. Dragovich, Yichin Liu, Katherine R. Kozak
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
For antibody-drug conjugates to be efficacious and safe, they must be stable in circulation to carry the payload to the site of the targeted cell. Several components of a drug-conjugated antibody are known to influence stability: 1) the site of drug
Externí odkaz:
https://doaj.org/article/e46e20ec184a4063ba55b87d5b9f2d28
Autor:
Thomas H. Pillow, Andrew G. Polson, Peter S. Dragovich, Hans K. Erickson, Pragya Adhikari, John Wai, Zijin Xu, Jinhua Chen, Katherine R. Kozak, Josefa dela Cruz-Chuh, Keyang Xu, Carl Ng, Amrita V. Kamath, Douglas D. Leipold, Shang-Fan Yu, Mary Ann T. Go, Geoffrey del Rosario, Fiona Zhong, Melissa M. Schutten, Chris Frantz, Breanna S. Vollmar
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5429ac6c382f94a2b29d630d8d1ebd26
https://doi.org/10.1158/1535-7163.22522233
https://doi.org/10.1158/1535-7163.22522233
Autor:
Jagath R. Junutula, John A. Flygare, Andrew G. Polson, Paul Polakis, Susan Spencer, Katherine K. Kozak, Janet Gunzner-Toste, Jinhua Chen, Fan Fang, Philip W. Howard, Stephen J. Gregson, Luke Masterson, Donglu Zhang, Amrita V. Kamath, Douglas D. Leipold, Keyang Xu, Carl Ng, Luna Liu, Jintang He, Sharon Yee, Jeffrey Lau, Mary Ann T. Go, Geoffrey Del Rosario, Fiona Zhong, Willy Solis, Kirsten Achilles Poon, Jack Sadowsky, Rachana Ohri, Shang-Fan Yu, Melissa Schutten, Thomas H. Pillow
Supplementary Figures S1-S5, Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bd04853a3b7478b1a76289e951f293
https://doi.org/10.1158/1535-7163.22503312.v1
https://doi.org/10.1158/1535-7163.22503312.v1
Autor:
Thomas H. Pillow, Andrew G. Polson, Peter S. Dragovich, Hans K. Erickson, Pragya Adhikari, John Wai, Zijin Xu, Jinhua Chen, Katherine R. Kozak, Josefa dela Cruz-Chuh, Keyang Xu, Carl Ng, Amrita V. Kamath, Douglas D. Leipold, Shang-Fan Yu, Mary Ann T. Go, Geoffrey del Rosario, Fiona Zhong, Melissa M. Schutten, Chris Frantz, Breanna S. Vollmar
Calicheamicin antibody–drug conjugates (ADCs) are effective therapeutics for leukemias with two recently approved in the United States: Mylotarg (gemtuzumab ozogamicin) targeting CD33 for acute myeloid leukemia and Besponsa (inotuzumab ozogamicin)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953a865f6922c43da57998015e9032ac
https://doi.org/10.1158/1535-7163.c.6543312.v1
https://doi.org/10.1158/1535-7163.c.6543312.v1
Autor:
Neelie Zacharias, Vladimir N. Podust, Kimberly K. Kajihara, Douglas Leipold, Geoffrey Del Rosario, Desiree Thayer, Emily Dong, Maciej Paluch, David Fischer, Kai Zheng, Corinna Lei, Jintang He, Carl Ng, Dian Su, Luna Liu, Shabkhaiz Masih, William Sawyer, Jeff Tinianow, Jan Marik, Victor Yip, Guangmin Li, Josefa Chuh, J. Hiroshi Morisaki, Summer Park, Bing Zheng, Hilda Hernandez-Barry, Kelly M. Loyet, Min Xu, Katherine R. Kozak, Gail Lewis Phillips, Ben-Quan Shen, Cong Wu, Keyang Xu, Shang-Fan Yu, Amrita Kamath, Rebecca K. Rowntree, Dorothea Reilly, Thomas Pillow, Andrew Polson, Volker Schellenberger, Wouter L. W. Hazenbos, Jack Sadowsky
Publikováno v:
Chemical Science. 13:3147-3160
The antibody-drug conjugate (ADC) is a well-validated modality for the cell-specific delivery of small molecules with impact expanding rapidly beyond their originally-intended purpose of treating cancer. However, antibody-mediated delivery (AMD) rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bce602efd8f14a1021c22dad6d1512
https://doi.org/10.1039/d1sc05243h
https://doi.org/10.1039/d1sc05243h
Growth under cold conditions in a wide perennial ryegrass panel is under tight physiological control
Publikováno v:
PeerJ, Vol 6, p e5520 (2018)
Background Perennial ryegrass is a cool-season grass species from the family Poaceae and is widely cultivated in temperate regions because it exhibits rapid growth and establishment, and possesses high forage quality. The extension of the growing sea
Externí odkaz:
https://doaj.org/article/cbca4be8a01945d89362a400e66f323b
Autor:
Lingyao Meng, Emily W. Chan, Carl Ng, Junko Aimi, John C. Tran, Angela J. Oh, Mark Merchant, Hans E. Purkey, Timothy P. Heffron, Surinder Kaur, Keyang Xu, Zhen Shi, Jintang He
Publikováno v:
Analytical chemistry. 94(37)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504287de6a6fc7658756ee7a60730321
https://pubmed.ncbi.nlm.nih.gov/36083155
https://pubmed.ncbi.nlm.nih.gov/36083155
Autor:
Ben-Quan Shen, Shab Masih, Brandon Latifi, Isabel Figueroa, Carl Ng, Doug Leipold, Victor Yip, Amrita V. Kamath
Publikováno v:
Drug Metabolism and Disposition. 48:1247-1256
Anti-Ly6E-seco-cyclopropabenzindol-4-one dimer antibody-drug conjugate (ADC) has been reported to form an adduct with α1-microglobulin (A1M) in animal plasma, but with unknown impact on ADC PK and tissue distribution. In this study, we compared the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::945bc3da68bd20d4c91007d4f9bab16e
https://doi.org/10.1124/dmd.120.000145
https://doi.org/10.1124/dmd.120.000145
Autor:
Volker Schellenberger, David Fischer, Bing Zheng, Thomas H. Pillow, Amrita V. Kamath, Carl Ng, Jan Marik, Corinna Lei, Dorothea Reilly, Shabkhaiz Masih, Kelly M. Loyet, Vladimir N. Podust, Kimberly Kajihara, Maciej Paluch, Andrew Polson, Gail Dianne Phillips, Summer Park, Luna Liu, Morisaki John Hiroshi, Kai Zheng, Guangmin Li, Dian Su, Douglas D. Leipold, Josefa Chuh, Victor Yip, Emily Dong, Shang-Fan Yu, Wouter L. W. Hazenbos, Jack Sadowsky, Geoffrey Del Rosario, Rebecca K. Rowntree, Jeff N. Tinianow, Neelie Zacharias, Min Xu, William S. Sawyer, Katherine R. Kozak, Hilda Hernandez-Barry, Jintang He, Cong Wu, Keyang Xu, Ben-Quan Shen
Antibody-drug conjugates (ADCs) enable cell-specific delivery of small molecules and are validated anti-cancer therapeutics. One factor limiting ADC advancement and broader application is the drug-to-antibody ratio (DAR), which dictates the number of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7d05e7d54cc2ba403b546592bdee064
https://doi.org/10.21203/rs.3.rs-356231/v1
https://doi.org/10.21203/rs.3.rs-356231/v1