Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Carl, Högberg"'
Autor:
Carl Sandén, Henrik Lilljebjörn, Christina Orsmark Pietras, Rasmus Henningsson, Karim H. Saba, Niklas Landberg, Hanna Thorsson, Sofia von Palffy, Pablo Peña-Martinez, Carl Högberg, Marianne Rissler, David Gisselsson, Vladimir Lazarevic, Gunnar Juliusson, Helena Ågerstam, Thoas Fioretos
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Clonal evolution and heterogeneity has strong implications for treatment response in acute myeloid leukemia. Here, the authors use patient derived in vivo modelling to highlight the complex clonal and evolutionary dynamics underpinning acute myeloid
Externí odkaz:
https://doaj.org/article/e35f9025834f4b02be68bf3c32279eaa
Autor:
Pablo Peña-Martínez, Ramprasad Ramakrishnan, Carl Högberg, Caroline Jansson, David Gisselsson Nord, Marcus Järås
Publikováno v:
Haematologica, Vol 107, Iss 4 (2021)
Cytokines are key regulators of tumor immune surveillance by controlling immune cell activity. Here, we investigated whether interleukin 4 (IL4) has antileukemic activity via immune-mediated mechanisms in an in vivo murine model of acute myeloid leuk
Externí odkaz:
https://doaj.org/article/b4b28945e7174ef3ab80a75d45cb56df
Autor:
Ramprasad Ramakrishnan, Pablo Peña-Martínez, Puneet Agarwal, Maria Rodriguez-Zabala, Marion Chapellier, Carl Högberg, Mia Eriksson, David Yudovich, Mansi Shah, Mats Ehinger, Björn Nilsson, Jonas Larsson, Anna Hagström-Andersson, Benjamin L. Ebert, Ravi Bhatia, Marcus Järås
Publikováno v:
Cell Reports, Vol 31, Iss 8, Pp - (2020)
Summary: Acute myeloid leukemia (AML) is defined by an accumulation of immature myeloid blasts in the bone marrow. To identify key dependencies of AML stem cells in vivo, here we use a CRISPR-Cas9 screen targeting cell surface genes in a syngeneic ML
Externí odkaz:
https://doaj.org/article/833e4337d372485e83bc07664288cbbe
Autor:
Mia Eriksson, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Marion Chapellier, Carl Högberg, Gabriella Glowacki, Christina Orsmark-Pietras, Talía Velasco-Hernández, Vladimir Lj Lazarević, Gunnar Juliusson, Jörg Cammenga, James C. Mulloy, Johan Richter, Thoas Fioretos, Benjamin L. Ebert, Marcus Järås
Publikováno v:
Blood Advances, Vol 1, Iss 23, Pp 2046-2057 (2017)
Abstract: Acute myeloid leukemia (AML) is associated with poor survival, and there is a strong need to identify disease vulnerabilities that might reveal new treatment opportunities. Here, we found that Toll-like receptor 1 (TLR1) and TLR2 are upregu
Externí odkaz:
https://doaj.org/article/71cdb79d494b42dc877ffcc4c6b15024
Autor:
Marion Chapellier, Pablo Peña-Martínez, Ramprasad Ramakrishnan, Mia Eriksson, Mehrnaz Safaee Talkhoncheh, Christina Orsmark-Pietras, Henrik Lilljebjörn, Carl Högberg, Anna Hagström-Andersson, Thoas Fioretos, Jonas Larsson, Marcus Järås
Publikováno v:
Haematologica, Vol 104, Iss 10 (2019)
Dysregulation of cytokines in the bone marrow (BM) microenvironment promotes acute myeloid leukemia (AML) cell growth. Due to the complexity and low throughput of in vivo stem-cell based assays, studying the role of cytokines in the BM niche in a scr
Externí odkaz:
https://doaj.org/article/27c172da456b48258fb009594489e036
Autor:
Maria Askmyr, Sofia von Palffy, Nils Hansen, Niklas Landberg, Carl Högberg, Marianne Rissler, Helena Ågerstam, Thoas Fioretos
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186035 (2017)
Several attempts have been made to model chronic myeloid leukemia (CML) in a xenograft setting but expansion of human myeloid cells in immunodeficient mice has proven difficult to achieve. Lack of cross-reacting cytokines in the microenvironment of t
Externí odkaz:
https://doaj.org/article/a938ecc523ba4ef092d12c61d5f42f77
Autor:
Nils Hansen, Pablo Peña, Finja Hansen, Petter Skoog, Susanne Larsson Faria, Karin von Wachenfeldt, Carl Högberg, Camilla Rydberg Millrud, David Liberg, Marcus Järås
Publikováno v:
Cancer Research. 82:C055-C055
IL1RAP is expressed by tumor and stromal cells in pancreatic ductal adenocarcinoma (PDAC). Signaling by IL1 through the IL1R1/IL1RAP complex promotes cancer progression and contributes to the immune suppressive microenvironment in PDAC. The IL1RAP-bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::296707ebf1d195e0112291d12805d8a2
https://doi.org/10.1158/1538-7445.panca22-c055
https://doi.org/10.1158/1538-7445.panca22-c055
Autor:
Pablo, Peña-Martínez, Ramprasad, Ramakrishnan, Carl, Högberg, Caroline, Jansson, David Gisselsson, Nord, Marcus, Järås
Publikováno v:
Haematologica. 107(4)
Cytokines are key regulators of tumor immune surveillance by controlling immune cell activity. Here, we investigated whether interleukin 4 (IL4) has antileukemic activity via immune-mediated mechanisms in an in vivo murine model of acute myeloid leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0f027bab246757d169406f04c5d38e57
https://pubmed.ncbi.nlm.nih.gov/33951888
https://pubmed.ncbi.nlm.nih.gov/33951888
Autor:
Gunnar Juliusson, Carl Högberg, Gabriella Glowacki, Ramprasad Ramakrishnan, Marcus Järås, Christina Orsmark-Pietras, James C. Mulloy, Talia Velasco-Hernandez, Benjamin L. Ebert, Mia Eriksson, Thoas Fioretos, Marion Chapellier, Johan Richter, Vladimir Lazarevic, Jörg Cammenga, Pablo Peña-Martínez
Publikováno v:
Blood Advances. 1:2046-2057
Acute myeloid leukemia (AML) is associated with poor survival, and there is a strong need to identify disease vulnerabilities that might reveal new treatment opportunities. Here, we found that Toll-like receptor 1 (TLR1) and TLR2 are upregulated on p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c912111601cbc06b85a0d0aafff832b0
https://doi.org/10.1182/bloodadvances.2017006148
https://doi.org/10.1182/bloodadvances.2017006148
Autor:
Mia Eriksson, Christina Orsmark-Pietras, Ramprasad Ramakrishnan, Marcus Järås, Thoas Fioretos, Marion Chapellier, Johan Richter, Anna Andersson, Pablo Peña-Martínez, Carl Högberg
Publikováno v:
Leukemia
Cytokines provide signals that regulate immature normal and acute myeloid leukemia (AML) cells in the bone marrow microenvironment. We here identify interleukin 4 (IL4) as a selective inhibitor of AML cell growth and survival in a cytokine screen usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b6f599de4cd63fb5650e52eaab964e
https://doi.org/10.1038/leu.2017.261
https://doi.org/10.1038/leu.2017.261