Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Carissa Perez Olsen"'
Autor:
Mark A. Xatse, Carissa Perez Olsen
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Glucosylceramides (GlcCer) are lipids that impact signaling pathways, serve as critical components of cellular membranes, and act as precursors for hundreds of other complex glycolipid species. Abnormal GlcCer metabolism is linked to many diseases, i
Externí odkaz:
https://doaj.org/article/e54203c1a3fe41408d802d6dc358946f
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 7, Pp 100394- (2023)
The addition of excess glucose to the diet drives a coordinated response of lipid metabolism pathways to tune the membrane composition to the altered diet. Here, we have employed targeted lipidomic approaches to quantify the specific changes in the p
Externí odkaz:
https://doaj.org/article/639d92dde63c496ea9af59fea1ea82d5
Publikováno v:
Metabolites, Vol 13, Iss 12, p 1185 (2023)
A key response to glucose stress is an increased production of unsaturated fatty acids to balance the increase in saturated fatty acids in the membrane. The C. elegans homolog of stearoyl-CoA desaturase, FAT-7, introduces the first double bond into s
Externí odkaz:
https://doaj.org/article/cf225fd95ed4493abd9c06cebde2bf83
Autor:
Anthony O. Beas, Patricia B. Gordon, Clara L. Prentiss, Carissa Perez Olsen, Matthew A. Kukurugya, Bryson D. Bennett, Susan M. Parkhurst, Daniel E. Gottschling
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Age-associated metabolic changes include lipid accumulation. Here, the authors show that with replicative aging yeast accumulate lipid droplets which protect cells from cold stress and can be modulated through Biosynthesis of NAD+ 2 (BNA2).
Externí odkaz:
https://doaj.org/article/ccc42411f0664158949caf4ea685050d
Autor:
Christopher F Bennett, Jane J Kwon, Christine Chen, Joshua Russell, Kathlyn Acosta, Nikolay Burnaevskiy, Matthew M Crane, Alessandro Bitto, Helen Vander Wende, Marissa Simko, Victor Pineda, Ryan Rossner, Brian M Wasko, Haeri Choi, Shiwen Chen, Shirley Park, Gholamali Jafari, Bryan Sands, Carissa Perez Olsen, Alexander R Mendenhall, Philip G Morgan, Matt Kaeberlein
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006695 (2017)
Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously,
Externí odkaz:
https://doaj.org/article/16244a054fa74a9d8488d864fa5e9844
Autor:
Francis Raj Gandhi Amrit, Elizabeth Marie Steenkiste, Ramesh Ratnappan, Shaw-Wen Chen, T Brooke McClendon, Dennis Kostka, Judith Yanowitz, Carissa Perez Olsen, Arjumand Ghazi
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006381 (2016)
[This corrects the article DOI: 10.1371/journal.pgen.1005788.].
Externí odkaz:
https://doaj.org/article/ddad647a1e464f85a16e93b887673748
Autor:
Francis Raj Gandhi Amrit, Elizabeth Marie Steenkiste, Ramesh Ratnappan, Shaw-Wen Chen, T Brooke McClendon, Dennis Kostka, Judith Yanowitz, Carissa Perez Olsen, Arjumand Ghazi
Publikováno v:
PLoS Genetics, Vol 12, Iss 2, p e1005788 (2016)
Elimination of the proliferating germline extends lifespan in C. elegans. This phenomenon provides a unique platform to understand how complex metazoans retain metabolic homeostasis when challenged with major physiological perturbations. Here, we dem
Externí odkaz:
https://doaj.org/article/e9b1de88bb9f42128e1e66cbc91678b6
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167229 (2016)
Despite the fact that the discovery of ether-linked phospholipids occurred nearly a century ago, many unanswered questions remain concerning these unique lipids. Here, we characterize the ether-linked lipids of the nematode with HPLC-MS/MS and find t
Externí odkaz:
https://doaj.org/article/c4997f45c2be46ac87f14d477841282a
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141850 (2015)
Membranes define cellular and organelle boundaries, a function that is critical to all living systems. Like other biomolecules, membrane lipids are dynamically maintained, but current methods are extremely limited for monitoring lipid dynamics in liv
Externí odkaz:
https://doaj.org/article/544becc0193d49299e7e33c8f41e11a1
Autor:
Daniel Lockshon, Carissa Perez Olsen, Christopher L Brett, Andrei Chertov, Alexey J Merz, Daniel A Lorenz, Marc R Van Gilst, Brian K Kennedy
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45049 (2012)
Preservation of both the integrity and fluidity of biological membranes is a critical cellular homeostatic function. Signaling pathways that govern lipid bilayer fluidity have long been known in bacteria, yet no such pathways have been identified in
Externí odkaz:
https://doaj.org/article/6d006fe966ef4ab49fc12a2321c444c0