Standardization of Cell Culture Conditions and Routine Genomic Screening under a Quality Management System Leads to Reduced Genomic Instability in hPSCs

Autor: Francisco J. Molina-Ruiz, Clelia Introna, Georgina Bombau, Mireia Galofre, Josep M. Canals

Publikováno v: Cells; Volume 11; Issue 13; Pages: 1984

Human pluripotent stem cells (hPSCs) have generated unprecedented interest in the scientific community, given their potential applications in regenerative medicine, disease modeling, toxicology and drug screening. However, hPSCs are prone to acquire

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689eb951c77bc2d531048936605cab7f
http://hdl.handle.net/2445/195640

Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions

Autor: Puiggros, Anna, Collado, Rosa, Calasanz, M.J, Ortega, Margarita, Ruiz-Xivillé, Neus, Rivas-Delgado, Alfredo, Luño, Elisa, González, Teresa, Navarro, Blanca, García-Malo, MaDolores, Valiente, Alberto, Hernández, José Ángel, Ardanaz, María Teresa, Piñan, María Ángeles, Blanco, María Laura, Hernández-Sánchez, María, Batlle-López, Ana, Salgado Sánchez, Rocío Nieves, Salido, Marta, Ferrer, Ana, Abrisqueta, Pau, Gimeno, Eva, Abella Monreal, Eugenia, Ferrá, Christelle, Terol, María José, Ortuño, Francisco, Costa, Dolors, Moreno, Carol, Carbonell, Félix, Bosch José, Francesc Xavier, Delgado, Julio, Espinet i Solà, Blanca, Universitat Autònoma de Barcelona

Publikováno v: Oncotarget
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Digital.CSIC. Repositorio Institucional del CSIC

Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex karyotypes (CK) with or without hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c33ee14ec31e9747ff312aaabe5987a
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6351

Generation of two compound heterozygous HGSNAT-mutated lines from healthy induced pluripotent stem cells using CRISPR/Cas9 to model Sanfilippo C syndrome

Autor: Daniel Grinberg, María García-Morant, Edgar Creus-Bachiller, Isaac Canals, Noelia Benetó, Mónica Cozar, Lluïsa Vilageliu

Publikováno v: Stem Cell Research. 41:101616

Sanfilippo C syndrome (Mucopolysaccharidosis IIIC) is a rare lysosomal storage disorder caused by mutations in the HGSNAT gene. It is characterized by a progressive and severe neurodegeneration, for which there is no treatment available. Here, we rep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a799264443e37b82554b6f028fc36e1
https://doi.org/10.1016/j.scr.2019.101616

DNA methylation profiles and their relationship with cytogenetic status in adult acute myeloid leukemia

Autor: Javier Suela, Juan C. Cigudosa, Alba Maiques, Agustín F. Fernández, Xabier Agirre, Manel Esteller, Sara Alvarez, Sandra Rodriguez Perales, Mark Wunderlich, Francesco Acquadro, Ana Valencia, José I. Martín-Subero, Felipe Prosper, Miguel A. Sanz, María José Calasanz, José Cervera, Reiner Siebert, Jose Roman-Gomez, James C. Mulloy

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Dadun. Depósito Académico Digital de la Universidad de Navarra
PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12197 (2010)

Background: Aberrant promoter DNA methylation has been shown to play a role in acute myeloid leukemia (AML) pathophysiology. However, further studies to discuss the prognostic value and the relationship of the epigenetic signatures with defined genom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87b20873a210cbac675f136a9161dd8
http://hdl.handle.net/2445/69603

Genetic characterization of Sezary's syndrome by conventional cytogenetics and cross-species color banding fluorescent in situ hybridization

Autor: Blanca Espinet, Salido, M., Pujol, R. M., Florensa, L., Gallardo, F., Domingo, A., Servitje, O., Estrach, T., García-Muret, P., Woessner, S., Serrano, S., Solé, F.

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Scopus-Elsevier

Background and objectives: Sezary's syndrome is a peripheral T-cell neoplasm characterized by a pruritic exfoliative or infiltrated erythroderma, lymphadenopathies, and atypical T lymphocytes in the peripheral blood. Cytogenetic studies are scarce. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5492f5650042630c7b06f52342705302
http://hdl.handle.net/2445/172770