Disrupted basolateral amygdala circuits supports negative valence bias in depressive states

Autor: Mathilde Bigot, Claire-Hélène De Badts, Axel Benchetrit, Éléonore Vicq, Carine Moigneu, Manon Meyrel, Sébastien Wagner, Alexandru Adrian Hennrich, Josselin Houenou, Pierre-Marie Lledo, Chantal Henry, Mariana Alonso

Publikováno v: Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)

Abstract Negative bias is an essential characteristic of depressive episodes leading patients to attribute more negative valence to environmental cues. This negative bias affects all levels of information processing including emotional response, atte

Externí odkaz: https://doaj.org/article/bb266f6aecf74b9aa0cc944c75f8979e

Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine

Autor: Eleni Siopi, Grégoire Chevalier, Lida Katsimpardi, Soham Saha, Mathilde Bigot, Carine Moigneu, Gérard Eberl, Pierre-Marie Lledo

Publikováno v: Cell Reports, Vol 30, Iss 11, Pp 3682-3690.e6 (2020)

Summary: Major depressive disorders (MDDs) constitute a leading cause of disability worldwide and current pharmacological treatments are partially effective. The gut microbiota (GM) has recently emerged as a target of therapeutic interest for MDDs. I

Externí odkaz: https://doaj.org/article/3b0ffaea640e40608b2d3803b0312c35

The neuropeptide VIP potentiates intestinal innate type 2 and type 3 immunity in response to feeding

Autor: Maud Pascal, Alexander Kazakov, Grégoire Chevalier, Lola Dubrule, Julie Deyrat, Alice Dupin, Soham Saha, Ferdinand Jagot, Kurt Sailor, Sophie Dulauroy, Carine Moigneu, Yasmine Belkaid, Gabriel Lepousez, Pierre-Marie Lledo, Christoph Wilhelm, Gérard Eberl

Publikováno v: Mucosal Immunology
Mucosal Immunology, In press, ⟨10.1038/s41385-022-00516-9⟩

International audience; The nervous system and the immune system both rely on an extensive set of modalities to perceive and act on perturbations in the internal and external environments. During feeding, the intestine is exposed to nutrients that ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd41a263d12a7c1acfd201e49829ade
https://doi.org/10.1038/s41385-022-00516-9

Gut microbial dysbiosis requires vagus nerve integrity to promote depression

Autor: Eleni Siopi, Mathieu Galerne, Manon Rivagorda, Soham Saha, Carine Moigneu, Franck Oury, Pierre-Marie Lledo

Chronic stress constitutes a major risk factor for depression that can disrupt various aspects of homeostasis, including the gut microbiome (GM). We have recently shown that GM imbalance affects adult hippocampal (HPC) neurogenesis and induces depres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8ca161d7f3fde8731ade7482d78a19e
https://doi.org/10.21203/rs.3.rs-2046733/v1

A combination of two human monoclonal antibodies cures symptomatic rabies

Autor: Fabrizia Zatta, Roberta Aiello, Elise Brisebard, Grégory Jouvion, Guilherme D. Melo, Paola De Benedictis, Hervé Bourhy, Florence Larrous, Gabriel Lepousez, Davide Corti, Andrea Minola, Lauriane Kergoat, Carine Moigneu, Angela Salomoni, Camille Mazo, Florian Sonthonnax

Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, 2020, pp.e12628. ⟨10.15252/emmm.202012628⟩
EMBO Molecular Medicine, Vol 12, Iss 11, Pp n/a-n/a (2020)
EMBO Molecular Medicine, Wiley Open Access, 2020, pp.e12628. ⟨10.15252/emmm.202012628⟩

Rabies is a neglected disease caused by a neurotropic Lyssavirus, transmitted to humans predominantly by the bite of infected dogs. Rabies is preventable with vaccines or proper post‐exposure prophylaxis (PEP), but it still causes about 60,000 deat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe02be9aa835abb1583f7afee746eda6
https://hal-pasteur.archives-ouvertes.fr/pasteur-02983042