Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model.

Autor: Rita Silva-Gomes, Elly Marcq, Gabriela Trigo, Carine M Gonçalves, Adhemar Longatto-Filho, António G Castro, Jorge Pedrosa, Alexandra G Fraga

Publikováno v: PLoS Neglected Tropical Diseases, Vol 9, Iss 12, p e0004265 (2015)

Buruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans infection. BU is characterized by a wide range of clinical forms, including non-ulcerative cutaneous lesions that can evolve into severe ulcers if left untreated. Nevert

Externí odkaz: https://doaj.org/article/a65f4d0f9cd74cfab2cb1405677b9b95

Modulation of CD4 T cell function via CD6-targetingResearch in context

Autor: Raquel Filipa Freitas, Afonso Basto, Silvia C.P. Almeida, Rita F. Santos, Carine M. Gonçalves, Jesus Corria-Osorio, Tânia Carvalho, Alexandre M. Carmo, Vanessa G. Oliveira, Kalet Leon, Luis Graca

Publikováno v: EBioMedicine, Vol 47, Iss, Pp 427-435 (2019)

In recent years molecules involved on the immune synapse became successful targets for therapeutic immune modulation. CD6 has been extensively studied, yet, results regarding CD6 biology have been controversial, in spite of the ubiquitous presence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::ba1deccfd7943678fa3e8b23279ddd22
http://www.sciencedirect.com/science/article/pii/S2352396419305249

Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection

Autor: Joana Azeredo, Jorge Pedrosa, Hugo Alexandre Mendes Oliveira, Umender Sharma, Rita Silva-Gomes, Madhavi Hebbur, Alexandra G. Fraga, António G. Castro, Gabriela Trigo, Carine M. Gonçalves, Juan Dominguez, Ramya K. Murthy, Shamim Akhtar, Ana Rita Pacheco

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007113 (2019)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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PLoS Neglected Tropical Diseases

Buruli Ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans. Although the current antibiotic treatment for BU is effective, daily administrations for a prolonged period of time, combined with potential risk of severe side effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8b6f18a58166f5c5fd774a22ff6b8c
https://doaj.org/article/be335171665840bbb480559a2a6a4957

CD6, a Rheostat-Type Signalosome That Tunes T Cell Activation

Autor: Carine M. Gonçalves, Sónia N. Henriques, Rita F. Santos, Alexandre M. Carmo

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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Following T cell receptor triggering, T cell activation is initiated and amplified by the assembly at the TCR/CD3 macrocomplex of a multitude of stimulatory enzymes that activate several signaling cascades. The potency of signaling is, however, modul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d022a76c9dcd9c884e0bdea2c805f1
https://www.frontiersin.org/article/10.3389/fimmu.2018.02994/full

Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment

Autor: F. Miguel Gama, João Pedro Silva, Carine M. Gonçalves, António G. Castro, Rui Appelberg, Jorge Pedrosa, César Costa, Rita Silva-Gomes, Jeremy Sousa

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
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uberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, recently joined HIV/AIDS on the top rank of deadliest infectious diseases. Low patient compliance due to the expensive, long-lasting and multi-drug standard therapie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a4565b9fa0126cfe9b0999c1ccb203
https://hdl.handle.net/1822/41895