The homing of bone marrow stem cells is differentially activated in ischemic and valvular heart diseases and influenced by beta-blockers

Autor: Melissa Kristocheck, Lucinara D. Dias, Carine Ghem, Bruna Eibel, Renato A. K. Kalil, Melissa M. Markoski

Publikováno v: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-10 (2018)

Abstract Background Cell homing is the mechanism by which an injury releases signaling molecules that cause recruitment, proliferation, migration and differentiation of progenitor cells. Stromal derived factor-1 (SDF-1) and its receptor CXCR4 are key

Externí odkaz: https://doaj.org/article/6b2f5c4505bf42bdbccea8d8e316817b

Combined Analysis of Endothelial, Hematopoietic, and Mesenchymal Stem Cell Compartments Shows Simultaneous but Independent Effects of Age and Heart Disease

Autor: Carine Ghem, Lucinara Dadda Dias, Roberto Tofani Sant’Anna, Renato A. K. Kalil, Melissa Markoski, Nance Beyer Nardi

Publikováno v: Stem Cells International, Vol 2017 (2017)

Clinical trials using stem cell therapy for heart diseases have not reproduced the initial positive results obtained with animal models. This might be explained by a decreased regenerative capacity of stem cells collected from the patients. This work

Externí odkaz: https://doaj.org/article/970f2a22ed31480bb6399be151809b48

Comparação das metodologias óptica e de impedância para a determinação de parâmetros hematológicos no analisador Sysmex-XN

Autor: Jennifer Tassoni Staehler, Luana Moro, Gabriel Giron Corrêa, Luciana Scotti, Iuri Vicente Camargo Morkis, Carine Ghem

Publikováno v: Revista Brasileira de Análises Clínicas. 53

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::630bc5eb622ad313cbd2047a2f5da277
https://doi.org/10.21877/2448-3877.202102133

Mesenchymal stem cells from sternum: the type of heart disease, ischemic or valvular, does not influence the cell culture establishment and growth kinetics

Autor: Patricia Vianna Bonini Palma, Melissa Kristocheck da Silva, Carine Ghem, Karina Rabello Casali, Melissa Medeiros Markoski, Lucinara Dadda Dias, Nance Beyer Nardi, Beatriz D'Agord Schaan, Dimas Tadeu Covas, Renato A. K. Kalil, Grasiele Sausen

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
Journal of Translational Medicine
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-11 (2017)

Background In an attempt to increase the therapeutic potential for myocardial regeneration, there is a quest for new cell sources and types for cell therapy protocols. The pathophysiology of heart diseases may affect cellular characteristics and ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47cc0042939c8d39c3cb6ae0358e95d
https://doi.org/10.1186/s12967-017-1262-0

Serum Bilirubin Concentration in Patients With an Established Coronary Artery Disease

Autor: Carine Ghem, Simone Rossetto, Alexandre Schaan de Quadros, Carlos A. M. Gottschall, Rogério Sarmento-Leite

Publikováno v: International Heart Journal. 51:86-91

Bilirubin has been considered an antioxidant, with capacity to remove reactive species of oxygen. Studies have suggested that an increased bilirubin level promotes protection against atherosclerosis. The case group was composed of 100 patients with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828a818791ff5ea93d581d5f61432802
https://doi.org/10.1536/ihj.51.86