Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Carine Aubry"'
Autor:
A. James Wilson, Bhabatosh Chaudhuri, Yu Yam Chan, Daniel P. G. Emmerson, Marcos D. García, Sachin Mahale, Emma J. Murphy, Paul R. Jenkins, Michael P. Dickens, Carine Aubry
We present the design, synthesis and biological activity of a new series of substituted 3-(2-(1H-indol-1-yl)ethyl)-1H-indoles and 1,2-di(1H-indol-1-yl)alkanes as selective inhibitors of CDK4/cyclin D1. The compounds were designed to explore the relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3202648fcc8e68bbedcdb54ed03e86a7
Autor:
Sachin Mahale, Michael J. Sutcliffe, Bhabatosh Chaudhuri, Jean-Didier Maréchal, Paul R. Jenkins, Carine Aubry
Publikováno v:
Bioorganic chemistry. 34(5)
Tryptamine derivatives, a new structural class of cyclin dependent kinase 4 inhibitors, have been identified during extensive biological screening of synthetic molecules. The molecules were synthesized based on the structure of fascaplysin, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f17fe6286068b11336a741c431ef01
https://pubmed.ncbi.nlm.nih.gov/16904725
https://pubmed.ncbi.nlm.nih.gov/16904725
Autor:
Michael J. Sutcliffe, Sachin Mahale, Paul R. Jenkins, Bhabatosh Chaudhuri, Jean-Didier Maréchal, Carine Aubry, A. James Wilson
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(16)
Tryptamine derivatives, non-planar and potentially less toxic analogues of the anti-cancer agent fascaplysin, have been synthesised. They specifically inhibit Cdk4-D1 vis a vis Cdk2-A but, unlike fascaplysin, do not bind or intercalate DNA. CA224 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc7f6835480bc39c092183418d332bf
https://pubmed.ncbi.nlm.nih.gov/16750360
https://pubmed.ncbi.nlm.nih.gov/16750360
Autor:
Hubert Vaudry, Hassan Oulyadi, Xavier Pannecoucke, Guillaume Dutheuil, Carine Aubry, Jean-Charles Quirion, Jérôme Leprince
Publikováno v:
Journal of Peptide Science
Journal of Peptide Science, Wiley, 2006, 12 (2), pp.154-160. ⟨10.1002/psc.690⟩
Journal of Peptide Science, Wiley, 2006, 12 (2), pp.154-160. ⟨10.1002/psc.690⟩
International audience; cis 5-tert-butyl-L-proline (Cbp) was prepared rapidly and efficiently by the addition of low-valent tert-butyl cuprate to an aminal derived from proline. [Cbp(2), D-Leu(5)]-OP was then synthesized, showing a predominant cis pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adb6b17dff00f74d78291befaaa33ac9
https://pubmed.ncbi.nlm.nih.gov/16138385
https://pubmed.ncbi.nlm.nih.gov/16138385
Autor:
Michael J. Sutcliffe, Carine Aubry, Sachin Mahale, Paul R. Jenkins, Asma Patel, Bhabatosh Chaudhuri, Jean-Didier Maréchal
We present the design, synthesis and biological activity of novel 3-[2-indol-1-yl-ethyl]-1H-indole selective inhibitors of CDK4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a7b238b4f4d044f36e042f5e4b3fc6
https://doi.org/10.1016/j.tetlet.2005.01.054
https://doi.org/10.1016/j.tetlet.2005.01.054
Autor:
Bhabatosh Chaudhuri, Paul R. Jenkins, Michael J. Sutcliffe, Jean-Didier Maréchal, Sachin Mahale, Carine Aubry
Publikováno v:
ChemInform. 35
The first biologically active non-planar analogues of the toxic anti-cancer agent, fascaplysin, have been produced; we present the design, synthesis and biological activity of three tryptamine derivatives.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e55995ef2d755f606dff4525147943
https://doi.org/10.1002/chin.200450196
https://doi.org/10.1002/chin.200450196
Autor:
A. James Wilson, Carine Aubry, Bhabatosh Chaudhuri, Michael J. Sutcliffe, Jean-Didier Maréchal, Sachin Mahale, Paul R. Jenkins
Publikováno v:
Organic & Biomolecular Chemistry. 4:787
We present the design, synthesis, and biological activity of three classes of tryptamine derivatives, which are non-planar analogues of the toxic anti-cancer agent fascaplysin. We show these compounds to be selective inhibitors of CDK4 over CDK2, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a92ab29160b116c72aa74b1dba8cae
https://doi.org/10.1039/b518019h
https://doi.org/10.1039/b518019h
Autor:
Carine Aubry, Paul R. Jenkins, Sachin Mahale, Bhabatosh Chaudhuri, Jean-Didier Maréchal, Michael J. Sutcliffe
Publikováno v:
Chemical Communications; Jul2004, Vol. 2004 Issue 15, p1696-1697, 2p