Preclinical Pharmacokinetics and Dosimetry of an 89Zr Labelled Anti-PDL1 in an Orthotopic Lung Cancer Murine Model

Autor: Anis Krache, Charlotte Fontan, Carine Pestourie, Manuel Bardiès, Yann Bouvet, Pierre Payoux, Etienne Chatelut, Melanie White-Koning, Anne-Sophie Salabert

Publikováno v: Frontiers in Medicine, Vol 8 (2022)

Anti-PDL1 is a monoclonal antibody targeting the programmed death-cell ligand (PD-L1) by blocking the programmed death-cell (PD-1)/PD-L1 axis. It restores the immune system response in several tumours, such as non-small cell lung cancer (NSCLC). Anti

Externí odkaz: https://doaj.org/article/7e88c75dd0124f899fc8b11d3c6144fe

Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis

Autor: Deborah Carper, Marine Coué, Emmani B.M. Nascimento, Valentin Barquissau, Damien Lagarde, Carine Pestourie, Claire Laurens, Justine Vily Petit, Maud Soty, Laurent Monbrun, Marie-Adeline Marques, Yannick Jeanson, Yannis Sainte-Marie, Aline Mairal, Sébastien Déjean, Geneviève Tavernier, Nathalie Viguerie, Virginie Bourlier, Frank Lezoualc’h, Audrey Carrière, Wim H.M. Saris, Arne Astrup, Louis Casteilla, Gilles Mithieux, Wouter van Marken Lichtenbelt, Dominique Langin, Patrick Schrauwen, Cedric Moro

Publikováno v: Cell Reports, Vol 32, Iss 8, Pp 108075- (2020)

Summary: Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and pressure in mammals. It is still unclear whether ANP controls cold-induced thermogenesis in vivo. Here, we show that acute cold exposure induces cardiac ANP s

Externí odkaz: https://doaj.org/article/c9d2ea13dbdc43ab985db4bbda177cc5

Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase.

Autor: Laura Cerchia, Frédéric Ducongé, Carine Pestourie, Jocelyne Boulay, Youssef Aissouni, Karine Gombert, Bertrand Tavitian, Vittorio de Franciscis, Domenico Libri

Publikováno v: PLoS Biology, Vol 3, Iss 4, p e123 (2005)

Targeting large transmembrane molecules, including receptor tyrosine kinases, is a major pharmacological challenge. Specific oligonucleotide ligands (aptamers) can be generated for a variety of targets through the iterative evolution of a random pool

Externí odkaz: https://doaj.org/article/ead8e11ade264496bfc22f633e942105

Atrial Natriuretic Peptide Orchestrates a Coordinated Physiological Response to Fuel Non-shivering Thermogenesis

Autor: Louis Casteilla, Marine Coué, Laurent Monbrun, Patrick Schrauwen, Damien Lagarde, Marie-Adeline Marques, Valentin Barquissau, Deborah Carper, Carine Pestourie, Justine Vily Petit, Yannick Jeanson, Cedric Moro, Nathalie Viguerie, Gilles Mithieux, Emmani B.M. Nascimento, Frank Lezoualc'h, Dominique Langin, Arne Astrup, Wouter D. van Marken Lichtenbelt, Aline Mairal, Claire Laurens, Audrey Carrière, Yannis Sainte-Marie, Sébastien Déjean, Wim H. M. Saris, Maud Soty, Geneviève Tavernier, Virginie Bourlier

Publikováno v: Cell Reports
Cell Reports, 2020, 32 (8), pp.1-20. ⟨10.1016/j.celrep.2020.108075⟩
Cell Reports, Elsevier Inc, 2020, 32 (8), pp.1-20. ⟨10.1016/j.celrep.2020.108075⟩
Cell Reports, Vol 32, Iss 8, Pp 108075-(2020)
Cell Reports, 32(8):108075. Cell Press
Carper, D, Coué, M, Nascimento, E B M, Barquissau, V, Lagarde, D, Pestourie, C, Laurens, C, Petit, J V, Soty, M, Monbrun, L, Marques, M-A, Jeanson, Y, Sainte-Marie, Y, Mairal, A, Déjean, S, Tavernier, G, Viguerie, N, Bourlier, V, Lezoualc'h, F, Carrière, A, Saris, W H M, Astrup, A, Casteilla, L, Mithieux, G, van Marken Lichtenbelt, W, Langin, D, Schrauwen, P & Moro, C 2020, ' Atrial natriuretic peptide orchestrates a coordinated physiological response to fuel non-shivering thermogenesis ', Cell Reports, vol. 32, no. 8, 108075 . https://doi.org/10.1016/j.celrep.2020.108075

The classical view is that brown adipose tissue (BAT) is mainly activated by the sympathetic nervous system. Carper et al. here demonstrate that the cardiac hormone atrial natriuretic peptide is released upon cold exposure and required to activate BA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cfa79404fc77ce8aa2d74ddbd99635
https://pubmed.ncbi.nlm.nih.gov/32846132

Radiolabeling of [18F]-fluoroethylnormemantine and initial in vivo evaluation of this innovative PET tracer for imaging the PCP sites of NMDA receptors

Autor: Charlotte Fontan, Mathieu Tafani, Carine Pestourie, Djilali Adel, A.S. Salabert, Pierre Payoux, Mathieu Alonso, Caroline Fonta, Hafid Belhadj-Tahar

Publikováno v: Nuclear Medicine and Biology
Nuclear Medicine and Biology, Elsevier, 2015, 42 (8), pp.643--653. ⟨10.1016/j.nucmedbio.2015.04.001⟩
Nuclear Medicine and Biology, 2015, 42 (8), pp.643--653. ⟨10.1016/j.nucmedbio.2015.04.001⟩

The N-methyl-D-aspartate receptor (NMDAr) is an ionotropic receptor that mediates excitatory transmission. NMDAr overexcitation is thought to be involved in neurological and neuropsychiatric disorders such as Alzheimer disease and schizophrenia. We s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e151a255acc4bc0f3a1813c6f13b8cc5
https://hal.archives-ouvertes.fr/hal-02344921