Assessment of an optimized manufacturing process for inactivated quadrivalent influenza vaccine: a phase III, randomized, double-blind, safety and immunogenicity study in children and adults

Autor: Carine Claeys, Mamadou Drame, José García-Sicilia, Khalequ Zaman, Alfonso Carmona, Phu My Tran, Mariano Miranda, Federico Martinón-Torres, Franck Thollot, Michael Horn, Tino F. Schwarz, Ulrich Behre, José M. Merino, Iwona Sadowska-Krawczenko, Henryk Szymański, Peter Schu, Elisabeth Neumeier, Ping Li, Varsha K. Jain, Bruce L. Innis

Publikováno v: BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-13 (2018)

Abstract Background GSK has modified the licensed monovalent bulk manufacturing process for its split-virion inactivated quadrivalent influenza vaccine (IIV4) to harmonize the process among different strains, resulting in an increased number of finis

Externí odkaz: https://doaj.org/article/9dc36b718bfa4646a1acdefeca5a764f

Immunogenicity of chimeric haemagglutinin-based, universal influenza virus vaccine candidates: interim results of a randomised, placebo-controlled, phase 1 clinical trial

Autor: Peter Palese, Anna-Karin E. Palm, Patrick C. Wilson, Marie Van der Wielen, Rahnuma Wahid, Michelle Dickey, Jeffrey T. Guptill, Rong Hai, Chris Gast, Haley L. Dugan, David I. Bernstein, Alicia Solórzano, Abdollah Naficy, Christopher T. Stamper, Monica M. McNeal, Raffael Nachbagauer, Min Gao, Emmanuel B. Walter, Linda Yu-Ling Lan, Randy A. Albrecht, Dustin G. Shaw, Florian Krammer, Micah E. Tepora, Jodi Feser, Heather Wenzel, Megan E Ermler, Jenna J. Guthmiller, D. Freeman, Bruce L Innis, Adolfo García-Sastre, Carine Claeys, Kristen N Buschle, Weina Sun, Teddy John Wohlbold, Carole Henry, Victoria Sutton, Francesco Berlanda-Scorza, Yao-Qing Chen

Publikováno v: The Lancet. Infectious Diseases
The Lancet. Infectious diseases, vol 20, iss 1

Summary Background Influenza viruses cause substantial annual morbidity and mortality globally. Current vaccines protect against influenza only when well matched to the circulating strains. However, antigenic drift can cause considerable mismatches b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0aaf8f19fab8daf9145b012346dd89
http://europepmc.org/articles/PMC6928577

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

Autor: Abdollah Naficy, Meagan McMahon, Emmanuel B. Walter, Jodi Feser, Florian Krammer, Disha Bhavsar, David I. Bernstein, Monica M. McNeal, Carine Claeys, Patrick C. Wilson, Alec W. Freyn, Alicia Solórzano, Veronika Chromikova, Juan Manuel Carreño, Chris Gast, Raffael Nachbagauer, Shirin Strohmeier, Peter Palese, Andres Javier, Carly M. Bliss, Jeffrey T. Guptill, Bruce L Innis, Teresa Aydillo, Daniel Stadlbauer, Adolfo García-Sastre, Marie Van der Wielen, Kaijun Jiang, Franceso Berlanda-Scorza, Lynda Coughlan, Weina Sun, Chiara Mariottini, Mohammad Amin Behzadi, Christina Capuano

Publikováno v: Nature medicine. 27(1)

Seasonal influenza viruses constantly change through antigenic drift and the emergence of pandemic influenza viruses through antigenic shift is unpredictable. Conventional influenza virus vaccines induce strain-specific neutralizing antibodies agains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f209222d6b16af0557867f82c814c7
https://pubmed.ncbi.nlm.nih.gov/33288923

A review of the value of quadrivalent influenza vaccines and their potential contribution to influenza control

Autor: Bruce L. Innis, Riju Ray, Philip O. Buck, Rafik Bekkat-Berkani, Gonçalo Matias, Carine Claeys, Gael Dos Santos

Publikováno v: Human Vaccines & Immunotherapeutics

The contribution of influenza B to the seasonal influenza burden varies from year-to-year. Although 2 antigenically distinct influenza B virus lineages have co-circulated since 2001, trivalent influenza vaccines (TIVs) contain antigens from only one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f0b9a82a84090de45919dcf84a9627
https://doi.org/10.1080/21645515.2017.1313375

Anamnestic Immune Response and Safety of an Inactivated Quadrivalent Influenza Vaccine in Primed Versus Vaccine-Naïve Children

Autor: Damien Friel, Thierry Ollinger, Renata Růžková, Ping Li, Varsha K. Jain, Carine Claeys, Jerzy Brzostek, Vijayalakshmi Chandrasekaran, Anne Schuind, Saul N. Faust, Angels Ulied, Roman Prymula, Matthew D. Snape, Javier Díez-Domingo, Andrew J. Pollard, Alfonso Carmona Martinez, José Garcia-Sicilia, Josep Marès-Bermúdez, Jyoti Soni, Mariano Miranda Valdivieso, Federico Martinón-Torres, Bruce L. Innis

Publikováno v: PEDIATRIC INFECTIOUS DISEASE JOURNAL
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
The Pediatric Infectious Disease Journal

Supplemental Digital Content is available in the text.
Background: It has not yet been demonstrated whether 2 doses of inactivated quadrivalent influenza vaccine (IIV4) prime a booster response in infants. We evaluated the anamnestic immune resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd95722ad3cdfcd2ac5d53d0d9ed0c1
https://hdl.handle.net/10668/13092