Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Carina Trummer"'
Autor:
Stefan Lorenzl, Franz Gottwald, Angelika Nistler, Laura Brehm, Renate Grötsch, Georg Haber, Christian Bremm, Christiane Weck, Carina Trummer, Werner Brand
Publikováno v:
Medical Cannabis and Cannabinoids, Vol 5, Iss 1, Pp 9-19 (2022)
Introduction: A phase I, open-label clinical trial in healthy male subjects was conducted to assess the pharmacokinetic and safety profile of an oromucosal cannabinoid spray (AP701) containing a lipid-based nanoparticular drug formulation standardize
Externí odkaz:
https://doaj.org/article/caa1eb492bc74f3dafd7d9c17e0f638c
Autor:
Christopher B. Mulholland, Atsuya Nishiyama, Joel Ryan, Ryohei Nakamura, Merve Yiğit, Ivo M. Glück, Carina Trummer, Weihua Qin, Michael D. Bartoschek, Franziska R. Traube, Edris Parsa, Enes Ugur, Miha Modic, Aishwarya Acharya, Paul Stolz, Christoph Ziegenhain, Michael Wierer, Wolfgang Enard, Thomas Carell, Don C. Lamb, Hiroyuki Takeda, Makoto Nakanishi, Sebastian Bultmann, Heinrich Leonhardt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-24 (2020)
Active and passive demethylation pathways have been implicated in the genome-wide erasure of 5mC accompanying mammalian preimplantation development. Here the authors reveal a recently evolved, mammalian-specific pathway in which global hypomethylatio
Externí odkaz:
https://doaj.org/article/de4c9930854d459f81d5177982c48222
Autor:
Atsuya Nishiyama, Christopher B. Mulholland, Sebastian Bultmann, Satomi Kori, Akinori Endo, Yasushi Saeki, Weihua Qin, Carina Trummer, Yoshie Chiba, Haruka Yokoyama, Soichiro Kumamoto, Toru Kawakami, Hironobu Hojo, Genta Nagae, Hiroyuki Aburatani, Keiji Tanaka, Kyohei Arita, Heinrich Leonhardt, Makoto Nakanishi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Ubiquitylation of histone H3 (H3Ub2) by UHRF1 recruits DNMT1 to chromatin, which is essential for DNA methylation inheritance. Here, the authors provide evidence that there are two distinct mechanisms underlying replication timing-dependent recruitme
Externí odkaz:
https://doaj.org/article/f213b943c175422e80039e7fcf8e3765
Autor:
Markus Schneider, Carina Trummer, Andreas Stengl, Peng Zhang, Aleksandra Szwagierczak, M Cristina Cardoso, Heinrich Leonhardt, Christina Bauer, Iris Antes
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229144 (2020)
The multi-domain protein UHRF1 is essential for DNA methylation maintenance and binds DNA via a base-flipping mechanism with a preference for hemi-methylated CpG sites. We investigated its binding to hemi- and symmetrically modified DNA containing ei
Externí odkaz:
https://doaj.org/article/d29f8fecd7c842fc8056379ded4f8f18
Autor:
Christopher B. Mulholland, Atsuya Nishiyama, Joel Ryan, Ryohei Nakamura, Merve Yiğit, Ivo M. Glück, Carina Trummer, Weihua Qin, Michael D. Bartoschek, Franziska R. Traube, Edris Parsa, Enes Ugur, Miha Modic, Aishwarya Acharya, Paul Stolz, Christoph Ziegenhain, Michael Wierer, Wolfgang Enard, Thomas Carell, Don C. Lamb, Hiroyuki Takeda, Makoto Nakanishi, Sebastian Bultmann, Heinrich Leonhardt
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20453-0
Externí odkaz:
https://doaj.org/article/a9ee0759a31e47a58878982b9e6289ee
Autor:
Hiroyuki Takeda, Edris Parsa, Joel Ryan, Merve Yiğit, Wolfgang Enard, Carina Trummer, Christoph Ziegenhain, Michael D. Bartoschek, Ivo M. Glück, Franziska R. Traube, Don C. Lamb, Weihua Qin, Sebastian Bultmann, Christopher B. Mulholland, Aishwarya Acharya, Miha Modic, Thomas Carell, Michael Wierer, Heinrich Leonhardt, Enes Ugur, Ryohei Nakamura, Atsuya Nishiyama, Makoto Nakanishi, Paul Stolz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20453-0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10442699ddca49ddafcd6bdd3303056c
https://doi.org/10.1038/s41467-020-20453-0
https://doi.org/10.1038/s41467-020-20453-0
Autor:
Yasushi Saeki, Carina Trummer, Akinori Endo, Sebastian Bultmann, Soichiro Kumamoto, Kyohei Arita, Atsuya Nishiyama, Genta Nagae, Makoto Nakanishi, Heinrich Leonhardt, Satomi Kori, Weihua Qin, Haruka Yokoyama, Hiroyuki Aburatani, Yoshie Chiba, Christopher B. Mulholland, Keiji Tanaka, Toru Kawakami, Hironobu Hojo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Stable inheritance of DNA methylation is critical for maintaining differentiated phenotypes in multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 (H3Ub2) by UHRF1 as an essential mechanism to recruit DNMT1 to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ddab9cafd3613a3ad02edc3daf818c
https://doi.org/10.1038/s41467-020-15006-4
https://doi.org/10.1038/s41467-020-15006-4
Autor:
Aleksandra Szwagierczak, Carina Trummer, Andreas Stengl, Christina Bauer, Heinrich Leonhardt, Iris Antes, M. Cristina Cardoso, Markus Schneider, Peng Zhang
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0229144 (2020)
PLoS ONE
PLoS ONE
The multi-domain protein UHRF1 is essential for DNA methylation maintenance and binds DNA via a base-flipping mechanism with a preference for hemi-methylated CpG sites. We investigated its binding to hemi- and symmetrically modified DNA containing ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f17c9abc1ed2039f15fcb25847392f
https://doaj.org/article/d29f8fecd7c842fc8056379ded4f8f18
https://doaj.org/article/d29f8fecd7c842fc8056379ded4f8f18
Autor:
Peng Zhang, Anne K. Ludwig, Udo Müller, Ines Hellmann, Cathia Rausch, Christian Storm, Florian D. Hastert, M. Cristina Cardoso, Henry D. Herce, Heinrich Leonhardt, Stephanie Meyer, Anne Lehmkuhl, Carina Trummer
Publikováno v:
Nucleic Acids Research
Aberrant DNA methylation is a hallmark of various human disorders, indicating that the spatial and temporal regulation of methylation readers and modifiers is imperative for development and differentiation. In particular, the cross-regulation between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d510c23033a014f51b98df07c5e5613
https://doi.org/10.1093/nar/gkw1197
https://doi.org/10.1093/nar/gkw1197
Autor:
Ivo M. Glück, Hiroyuki Takeda, Carina Trummer, Michael D. Bartoschek, Merve Yiğit, Michael Wierer, Makoto Nakanashi, Sebastian Bultmann, Christopher B. Mulholland, Atsuya Nishiyama, Joel Ryan, Aishwarya Acharya, Don C. Lamb, Christoph Ziegenhain, Thomas Carell, Franziska R. Traube, Edris Parsa, Weihua Qin, Ryohei Nakamura, Heinrich Leonhardt, Enes Ugur, Miha Modic, Wolfgang Enard, Paul Stolz
Genome-wide DNA demethylation is a unique feature of mammalian development and naïve pluripotent stem cells. So far, it was unclear how mammals specifically achieve global DNA hypomethylation, given the high conservation of the DNA (de-)methylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4da45db0302d0f150b7f37a68afb393
https://doi.org/10.1101/321604
https://doi.org/10.1101/321604
