Atomic force microscopy and other scanning probe microscopy methods to study nanoscale domains in model lipid membranes

Autor: Morgan Robinson, Carina T. Filice, Danielle M. McRae, Zoya Leonenko

Publikováno v: Advances in Physics: X, Vol 8, Iss 1 (2023)

ABSTRACTThe cell membrane is a fundamental biological structure, which is only 6–10 nm thick. It is composed of hundreds of lipid types, which form small and dynamic lipid domains or rafts. These rafts are thought to be a major aspect of cell organ

Externí odkaz: https://doaj.org/article/5ca44ec5ab5c4069b163111fef255547

C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition

Autor: Sergey Noskov, Zoya Leonenko, Carina T. Filice, Giuseppe Federico Amodeo, Natalya Krilyuk, Evgeny Pavlov, Daniel E. Otzen, Denis Valyuk, Brenda Yasie Lee

Publikováno v: Amodeo, G F, Lee, B Y, Krilyuk, N, Filice, C T, Valyuk, D, Otzen, D E, Noskov, S, Leonenko, Z & Pavlov, E V 2021, ' C subunit of the ATP synthase is an amyloidogenic calcium dependent channel-forming peptide with possible implications in mitochondrial permeability transition ', Scientific Reports, vol. 11, no. 1, 8744 . https://doi.org/10.1038/s41598-021-88157-z
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports

The c subunit is an inner mitochondrial membrane (IMM) protein encoded by three nuclear genes. Best known as an integral part of the F0 complex of the ATP synthase, the c subunit is also present in other cytoplasmic compartments in ceroid lipofuscino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ea19a692ff6863651b45b38fc9ddcb
https://pure.au.dk/portal/da/publications/c-subunit-of-the-atp-synthase-is-an-amyloidogenic-calcium-dependent-channelforming-peptide-with-possible-implications-in-mitochondrial-permeability-transition(db8fa361-bf7e-45fa-9754-fe90a93eebdf).html

C subunit of the ATP synthase is an amyloidogenic channel-forming peptide: possible implications in mitochondrial pathogenesis

Autor: Evgeny Pavlov, Giuseppe F. Amodeo, Carina T. Filice, Zoya Leonenko, Sergei Y. Noskov, Brenda Yasie Lee, Denis Valyuk, Natalya Krilyuk, Daniel E. Otzen

The c subunit is an inner mitochondrial membrane (IMM) protein and is an integral part of the F0 complex of the ATP synthase. Under physiological conditions, this short 75 residue-long peptide folds into an α-helical hairpin and forms oligomers span

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9d899cd0d963311314ff730ef9df47

Changes in Lipid Membrane May Trigger Amyloid Toxicity in Alzheimer's Disease

Autor: Morgan Robinson, Stephen J. Turnbull, Nanqin Mei, Eric Finot, Carina T. Filice, Evgeny Pavlov, Elizabeth Drolle, Zoya Leonenko, Brenda Yasie Lee

Publikováno v: Biophysical Journal. 116:427a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a29abff637971b5d1e21df796b747315
https://doi.org/10.1016/j.bpj.2018.11.2298