Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Carina Strell"'
Autor:
Carlos Fernández Moro, Natalie Geyer, Sara Harrizi, Yousra Hamidi, Sara Söderqvist, Danyil Kuznyecov, Evelina Tidholm Qvist, Media Salmonson Schaad, Laura Hermann, Amanda Lindberg, Rainer L. Heuchel, Alfonso Martín-Bernabé, Soniya Dhanjal, Anna C. Navis, Christina Villard, Andrea C. del Valle, Lorand Bozóky, Ernesto Sparrelid, Luc Dirix, Carina Strell, Arne Östman, Bernhard Schmierer, Peter B. Vermeulen, Jennie Engstrand, Béla Bozóky, Marco Gerling
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule’s extent and cellular composition in 263 patients with colorectal cancer live
Externí odkaz:
https://doaj.org/article/1e0e733410a64db5b9017544b7a2ff5f
Autor:
Benedek Bozóky, Carlos Fernández Moro, Carina Strell, Natalie Geyer, Rainer L. Heuchel, J. Matthias Löhr, Ingemar Ernberg, Laszlo Szekely, Marco Gerling, Béla Bozóky
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1300-1306 (2021)
Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive solid tumors. Based on transcriptomic classifiers, basal-like and classical PDAC subtypes have been defined that differ in prognosis. Cells of both subtypes can coexi
Externí odkaz:
https://doaj.org/article/91e8e2b3c7e24a6e950edafe3ff950a1
Autor:
Naoya Miyashita, Takayoshi Enokido, Masafumi Horie, Kensuke Fukuda, Hirokazu Urushiyama, Carina Strell, Hans Brunnström, Patrick Micke, Akira Saito, Takahide Nagase
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Epithelial–mesenchymal transition (EMT) is a cellular process during which epithelial cells acquire mesenchymal phenotypes. Cancer cells undergo EMT to acquire malignant features and TGF-β is a key regulator of EMT. Here, we demonstrate f
Externí odkaz:
https://doaj.org/article/d422005689cd47d1859b825318bebcb6
Autor:
Manuel Zeitelhofer, Milena Z. Adzemovic, Christine Moessinger, Christina Stefanitsch, Carina Strell, Lars Muhl, Lou Brundin, Linda Fredriksson, Tomas Olsson, Ulf Eriksson, Ingrid Nilsson
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-21 (2020)
Abstract Disruption of blood–brain barrier (BBB) integrity is a feature of various neurological disorders. Here we found that the BBB is differently affected during the preclinical, progression and remission phase of experimental autoimmune encepha
Externí odkaz:
https://doaj.org/article/18f04bdb2bef420e877bfd4a06c159be
Autor:
Jessica Svedlund, Carina Strell, Xiaoyan Qian, Kilian J.C. Zilkens, Nicholas P. Tobin, Jonas Bergh, Anieta M. Sieuwerts, Mats Nilsson
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 212-223 (2019)
Background: Gene expression analysis of breast cancer largely relies on homogenized tissue samples. Due to the high degree of cellular and molecular heterogeneity of tumor tissues, bulk tissue-based analytical approaches can only provide very limited
Externí odkaz:
https://doaj.org/article/f5f93d401bf2454087abbe0b8a1391c0
Autor:
Thomas Karsten Kilvaer, Mehrdad Rakaee, Turid Hellevik, Jørg Vik, Luigi De Petris, Tom Donnem, Carina Strell, Arne Ostman, Lill-Tove Rasmussen Busund, Inigo Martinez-Zubiaurre
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Abstract Preclinical evidence suggests that stromal expression of platelet-derived growth factor receptors (PDGFRs) stimulates tumor development and diminishes intratumoral drug uptake. In non-small cell lung cancer (NSCLC), the clinical relevance of
Externí odkaz:
https://doaj.org/article/41323426fa774eeb847449f5998643f9
Autor:
Patrick Micke, Carina Strell, Johanna Mattsson, Alfonso Martín-Bernabé, Hans Brunnström, Jutta Huvila, Malin Sund, Fredrik Wärnberg, Fredrik Ponten, Bengt Glimelius, Ina Hrynchyk, Siarhei Mauchanski, Salome Khelashvili, Gemma Garcia-Vicién, David G. Molleví, Per-Henrik Edqvist, Aine O´Reilly, Sara Corvigno, Hanna Dahlstrand, Johan Botling, Ulrika Segersten, Agnieszka Krzyzanowska, Anders Bjartell, Jacob Elebro, Margareta Heby, Sebastian Lundgren, Charlotta Hedner, David Borg, Jenny Brändstedt, Hanna Sartor, Per-Uno Malmström, Martin Johansson, Björn Nodin, Max Backman, Cecilia Lindskog, Karin Jirström, Artur Mezheyeuski
Publikováno v:
EBioMedicine, Vol 65, Iss , Pp 103269- (2021)
Background: The development of a reactive tumour stroma is a hallmark of tumour progression and pronounced tumour stroma is generally considered to be associated with clinical aggressiveness. The variability between tumour types regarding stroma frac
Externí odkaz:
https://doaj.org/article/26bb87848f8f441298d6b26084798ea5
Autor:
Artem Lomakin, Jessica Svedlund, Carina Strell, Milana Gataric, Artem Shmatko, Gleb Rukhovich, Jun Sung Park, Young Seok Ju, Stefan Dentro, Vitalii Kleshchevnikov, Vasyl Vaskivskyi, Tong Li, Omer Ali Bayraktar, Sarah Pinder, Andrea L. Richardson, Sandro Santagata, Peter J. Campbell, Hege Russnes, Moritz Gerstung, Mats Nilsson, Lucy R. Yates
Publikováno v:
Nature. 611:594-602
Genome sequencing of cancers often reveals mosaics of different subclones present in the same tumour1–3. Although these are believed to arise according to the principles of somatic evolution, the exact spatial growth patterns and underlying mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d07de3d7231c99d60cc6a1b6946694
https://doi.org/10.1038/s41586-022-05425-2
https://doi.org/10.1038/s41586-022-05425-2
Autor:
Teijo Pellinen, Lassi Paavolainen, Alfonso Martín-Bernabé, Renata Papatella Araujo, Carina Strell, Artur Mezheyeuski, Max Backman, Linnea La Fleur, Oscar Brück, Jonas Sjölund, Erik Holmberg, Katja Välimäki, Hans Brunnström, Johan Botling, Pablo Moreno-Ruiz, Olli Kallioniemi, Patrick Micke, Arne Östman
Publikováno v:
JNCI: Journal of the National Cancer Institute. 115:71-82
Background Cancer-associated fibroblasts (CAFs) are molecularly heterogeneous mesenchymal cells that interact with malignant cells and immune cells and confer anti- and protumorigenic functions. Prior in situ profiling studies of human CAFs have larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2886355aa307b64ba357bb37119b4600
https://doi.org/10.1093/jnci/djac178
https://doi.org/10.1093/jnci/djac178
Autor:
Vladan Milosevic, Reidunn J. Edelmann, Ingeborg Winge, Carina Strell, Artur Mezheyeuski, Gøril Knutsvik, Cecilie Askeland, Elisabeth Wik, Lars A. Akslen, Arne Östman
Publikováno v:
Breast Cancer Research and Treatment.
Purpose Angiogenesis is crucial for tumor growth and is one of the hallmarks of cancer. In this study, we analyzed microvessel density, vessel median size, and perivascular a-SMA expression as prognostic biomarkers in breast cancer. Methods Dual IHC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::642dd99a77706173b880f29cc7d18101
https://doi.org/10.1007/s10549-023-06974-4
https://doi.org/10.1007/s10549-023-06974-4