Výsledky vyhledávání - "Carina S D, Wink"

Diphenidine, a new psychoactive substance: metabolic fate elucidated with rat urine and human liver preparations and detectability in urine using GC-MS, LC-MSn, and LC-HR-MSn

Autor: Julian A. Michely, Carina S. D. Wink, Hans H. Maurer, Andrea Jacobsen-Bauer, Josef Zapp

Publikováno v: Drug Testing and Analysis. 8:1005-1014

Diphenidine is a new psychoactive substance (NPS) sold as a 'legal high' since 2013. Case reports from Sweden and Japan demonstrate its current use and the necessity of applying analytical procedures in clinical and forensic toxicology. Therefore, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bdff9245645add335dac9a57933e607
https://doi.org/10.1002/dta.1946

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Lefetamine, a controlled drug and pharmaceutical lead of new designer drugs: synthesis, metabolism, and detectability in urine and human liver preparations using GC-MS, LC-MSn, and LC-high resolution-MS/MS

Autor: Josef Zapp, Carina S. D. Wink, Hans H. Maurer, Golo M. J. Meyer

Publikováno v: Analytical and Bioanalytical Chemistry. 407:1545-1557

Lefetamine (N,N-dimethyl-1,2-diphenylethylamine, L-SPA) was marketed as an opioid analgesic in Japan and Italy. After being widely abused, it became a controlled substance. It seems to be a pharmaceutical lead for designer drugs because N-ethyl-1,2-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53edfeb8e257f40812bd14cf626cf15d
https://doi.org/10.1007/s00216-014-8414-3

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GC-MS, LC-MSn, LC-high resolution-MSn, and NMR studies on the metabolism and toxicological detection of mesembrine and mesembrenone, the main alkaloids of the legal high 'Kanna' isolated from Sceletium tortuosum

Autor: Carina S. D. Wink, Hans H. Maurer, Golo M. J. Meyer, Josef Zapp

Publikováno v: Analytical and Bioanalytical Chemistry. 407:761-778

Mesembrine and mesembrenone are the main alkaloids of Sceletium tortuosum, a plant species that was used for sedation and analgesia by the KhoiSan, previously known as Hottentots, a tribe in South Africa. After fermentation, the obtained preparation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75899b2e9ca6931029be62416ff85248
https://doi.org/10.1007/s00216-014-8109-9

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Lefetamine-derived designer drugsN-ethyl-1,2-diphenylethylamine (NEDPA) andN-iso-propyl-1,2-diphenylethylamine (NPDPA): Metabolism and detectability in rat urine using GC-MS, LC-MSnand LC-HR-MS/MS

Autor: Carina S. D. Wink, Andrea Jacobsen-Bauer, Hans H. Maurer, Golo M. J. Meyer, Markus R. Meyer, Dirk K. Wissenbach

Publikováno v: Drug Testing and Analysis. 6:1038-1048

N-Ethyl-1,2-diphenylethylamine (NEDPA) and N-iso-propyl-1,2-diphenylethylamine (NPDPA) are two designer drugs, which were confiscated in Germany in 2008. Lefetamine (N,N-dimethyl-1,2-diphenylethylamine, also named L-SPA), the pharmaceutical lead of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::41d26971b2ca7c29b60a2198bfa43eff
https://doi.org/10.1002/dta.1621

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Diphenidine, a new psychoactive substance: metabolic fate elucidated with rat urine and human liver preparations and detectability in urine using GC-MS, LC-MS

Autor: Carina S D, Wink, Julian A, Michely, Andrea, Jacobsen-Bauer, Josef, Zapp, Hans H, Maurer

Publikováno v: Drug testing and analysis. 8(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca76156c70993778e1e2fd9bd6abaee1
https://pubmed.ncbi.nlm.nih.gov/26811026

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Toxicokinetics of lefetamine and derived diphenylethylamine designer drugs-Contribution of human cytochrome P450 isozymes to their main phase I metabolic steps

Autor: Carina S. D. Wink, Markus R. Meyer, Golo M. J. Meyer, Hans H. Maurer

Publikováno v: Toxicology letters. 238(3)

Lefetamine was first marketed in the 1940s as an opioid analgesic. Since withdrawal symptoms were observed during treatment, it became a controlled substance. Its N-ethyl and N-iso-propyl derivatives appeared on the illicit drug market in 2008. Metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec2cbd28456a59b1a5e3393d4696dad2
https://pubmed.ncbi.nlm.nih.gov/26276083

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Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n)

Autor: Hans H. Maurer, Alain Turcant, Carina S. D. Wink, Markus R. Meyer, Tina Braun

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, Springer Verlag, 2015, 407 (3), pp.831-843. ⟨10.1007/s00216-014-8083-2⟩

International audience; 2,5-Dimethoxy-4-propylphenethylamine (2C-P) is a hallucinogenic designer drug of the phenethylamine class, the so-called 2Cs, named according to the ethyl spacer between the nitrogen and the aromatic ring. The aims of the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7064702acfc68bbbf773240f062b34
https://hal.archives-ouvertes.fr/hal-01389237

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Lefetamine-derived designer drugs N-ethyl-1,2-diphenylethylamine (NEDPA) and N-iso-propyl-1,2-diphenylethylamine (NPDPA): metabolism and detectability in rat urine using GC-MS, LC-MSn and LC-HR-MS/MS

Autor: Carina S D, Wink, Golo M J, Meyer, Dirk K, Wissenbach, Andrea, Jacobsen-Bauer, Markus R, Meyer, Hans H, Maurer

Publikováno v: Drug testing and analysis. 6(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4ae9ed3076fd97df9c035d66696f2a8f
https://pubmed.ncbi.nlm.nih.gov/24591097

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