Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Carina R, Maier"'
Autor:
Oliver Hartmann, Michaela Reissland, Carina R. Maier, Thomas Fischer, Cristian Prieto-Garcia, Apoorva Baluapuri, Jessica Schwarz, Werner Schmitz, Martin Garrido-Rodriguez, Nikolett Pahor, Clare C. Davies, Florian Bassermann, Amir Orian, Elmar Wolf, Almut Schulze, Marco A. Calzado, Mathias T. Rosenfeldt, Markus E. Diefenbacher
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Lung cancer is the most common cancer worldwide and the leading cause of cancer-related deaths in both men and women. Despite the development of novel therapeutic interventions, the 5-year survival rate for non-small cell lung cancer (NSCLC) patients
Externí odkaz:
https://doaj.org/article/25bb6c9a9e3b4539a37791d85b52657e
Autor:
Carina R. Maier, Oliver Hartmann, Cristian Prieto-Garcia, Kamal M. Al-Shami, Lisa Schlicker, Felix C. E. Vogel, Silke Haid, Kevin Klann, Viktoria Buck, Christian Münch, Werner Schmitz, Elias Einig, Bastian Krenz, Marco A. Calzado, Martin Eilers, Nikita Popov, Mathias T. Rosenfeldt, Markus E. Diefenbacher, Almut Schulze
Publikováno v:
Cell Death & Differentiation.
SREBP2 is a master regulator of the mevalonate pathway (MVP), a biosynthetic process that drives the synthesis of dolichol, heme A, ubiquinone and cholesterol and also provides substrates for protein prenylation. Here, we identify SREBP2 as a novel s
Autor:
Almut Schulze, Owen J. Sansom, Grace H. McGregor, David M. Gay, Mathias T. Rosenfeldt, Hecham Marouf, Charis Kalogirou, Madelon Paauwe, Susanne Walz, Carsten P. Ade, Beatrice Dankworth, Andrew D. Campbell, Werner Schmitz, Carina R. Maier, Irem Kaymak
This file includes extended experimental procedures including 1. Analysis of RNA-sequencing and Cancer Genome Atlas data 2. Generation of shRNA Cell Lines, 3. Automated cell counting, 4. Liquid chromatography and mass spectrometry, 5. BrdU staining o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d825d23bc231b7811b25ce1d89a26aa
https://doi.org/10.1158/0008-5472.22425040.v1
https://doi.org/10.1158/0008-5472.22425040.v1
Autor:
Almut Schulze, Owen J. Sansom, Grace H. McGregor, David M. Gay, Mathias T. Rosenfeldt, Hecham Marouf, Charis Kalogirou, Madelon Paauwe, Susanne Walz, Carsten P. Ade, Beatrice Dankworth, Andrew D. Campbell, Werner Schmitz, Carina R. Maier, Irem Kaymak
Oncogene activation and loss of tumor suppressor function changes the metabolic activity of cancer cells to drive unrestricted proliferation. Moreover, cancer cells adapt their metabolism to sustain growth and survival when access to oxygen and nutri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2af7ff76b801d0bbd7476b91e88f16
https://doi.org/10.1158/0008-5472.c.6511930.v1
https://doi.org/10.1158/0008-5472.c.6511930.v1
Autor:
Irem Kaymak, Carina R. Maier, Werner Schmitz, Andrew D. Campbell, Beatrice Dankworth, Carsten P. Ade, Susanne Walz, Madelon Paauwe, Charis Kalogirou, Hecham Marouf, Mathias T. Rosenfeldt, David M. Gay, Grace H. McGregor, Owen J. Sansom, Almut Schulze
Publikováno v:
Cancer Research. 80:189-203
Oncogene activation and loss of tumor suppressor function changes the metabolic activity of cancer cells to drive unrestricted proliferation. Moreover, cancer cells adapt their metabolism to sustain growth and survival when access to oxygen and nutri
Autor:
Kevin Klann, Ivan Dikic, Mathias Rosenfeldt, Christina Schülein-Völk, Christian Münch, Reinhard Kalb, Michaela Reissland, Markus E. Diefenbacher, Carina R. Maier, Oliver Hartmann, Cristian Prieto-Garcia, Thomas Fischer
Publikováno v:
Cell death and differentiation. 29(3)
Squamous cell carcinomas (SCC) frequently have a limited response to or develop resistance to platinum-based chemotherapy, and have an exceptionally high tumor mutational burden. As a consequence, overall survival is limited and novel therapeutic str
Autor:
Oliver, Hartmann, Michaela, Reissland, Carina R, Maier, Thomas, Fischer, Cristian, Prieto-Garcia, Apoorva, Baluapuri, Jessica, Schwarz, Werner, Schmitz, Martin, Garrido-Rodriguez, Nikolett, Pahor, Clare C, Davies, Florian, Bassermann, Amir, Orian, Elmar, Wolf, Almut, Schulze, Marco A, Calzado, Mathias T, Rosenfeldt, Markus E, Diefenbacher
Publikováno v:
Frontiers in Cell and Developmental Biology
Lung cancer is the most common cancer worldwide and the leading cause of cancer-related deaths in both men and women. Despite the development of novel therapeutic interventions, the 5-year survival rate for non-small cell lung cancer (NSCLC) patients
Autor:
Anke Vandekeere, Gianmarco Rinaldi, Alina M. Winkelkotte, Sarah-Maria Fendt, Dorien Broekaert, Almut Schulze, Martin F. Orth, Mouna Triki, Thomas G. P. Grunewald, Sudha Janaki Raman, Mélanie Planque, Joke Van Elsen, Carina R. Maier
Publikováno v:
Cell Reports
Summary Cancer cells display an increased plasticity in their lipid metabolism, which includes the conversion of palmitate to sapienate via the enzyme fatty acid desaturase 2 (FADS2). We find that FADS2 expression correlates with mammalian target of