Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes

Autor: Jérémie Gautheron, Lara Lima, Baris Akinci, Jamila Zammouri, Martine Auclair, Sema Kalkan Ucar, Samim Ozen, Canan Altay, Bridget E. Bax, Ivan Nemazanyy, Véronique Lenoir, Carina Prip-Buus, Cécile Acquaviva-Bourdain, Olivier Lascols, Bruno Fève, Corinne Vigouroux, Esther Noel, Isabelle Jéru

Publikováno v: BMC Medicine, Vol 20, Iss 1, Pp 1-21 (2022)

Abstract Background Thymidine phosphorylase (TP), encoded by the TYMP gene, is a cytosolic enzyme essential for the nucleotide salvage pathway. TP catalyzes the phosphorylation of the deoxyribonucleosides, thymidine and 2′-deoxyuridine, to thymine

Externí odkaz: https://doaj.org/article/f23ef112e8e2444f9f3eb4e619a1fccc

Plasma Metabolomic and Lipidomic Profiling of Metabolic Dysfunction-Associated Fatty Liver Disease in Humans Using an Untargeted Multiplatform Approach

Autor: Xiangping Lin, Xinyu Liu, Mohamed N. Triba, Nadia Bouchemal, Zhicheng Liu, Douglas I. Walker, Tony Palama, Laurence Le Moyec, Marianne Ziol, Nada Helmy, Corinne Vons, Guowang Xu, Carina Prip-Buus, Philippe Savarin

Publikováno v: Metabolites, Vol 12, Iss 11, p 1081 (2022)

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex disorder that is implicated in dysregulations in multiple biological pathways, orchestrated by interactions between genetic predisposition, metabolic syndromes and environmenta

Externí odkaz: https://doaj.org/article/3066e620ff9f41aaaa40cf3aa2285fe6

UCP2 Deficiency Increases Colon Tumorigenesis by Promoting Lipid Synthesis and Depleting NADPH for Antioxidant Defenses

Autor: Esther Aguilar, Pauline Esteves, Tiphaine Sancerni, Véronique Lenoir, Thomas Aparicio, Frédéric Bouillaud, Renaud Dentin, Carina Prip-Buus, Daniel Ricquier, Claire Pecqueur, Sandra Guilmeau, Marie-Clotilde Alves-Guerra

Publikováno v: Cell Reports, Vol 28, Iss 9, Pp 2306-2316.e5 (2019)

Summary: Colorectal cancer (CRC) is associated with metabolic and redox perturbation. The mitochondrial transporter uncoupling protein 2 (UCP2) controls cell proliferation in vitro through the modulation of cellular metabolism, but the underlying mec

Externí odkaz: https://doaj.org/article/018acc7a8f454f4fb747a5c73a8e0a30

Data from Mitochondrial Retrograde Signaling Mediated by UCP2 Inhibits Cancer Cell Proliferation and Tumorigenesis

Autor: Marie-Clotilde Alves-Guerra, Daniel Ricquier, Carina Prip-Buus, Anne Lombès, Anne-Laure Bulteau, Frédéric Bouillaud, Véronique Lenoir, Catherine Esnous, Céline Ransy, Claire Pecqueur, Pauline Esteves

Cancer cells tilt their energy production away from oxidative phosphorylation (OXPHOS) toward glycolysis during malignant progression, even when aerobic metabolism is available. Reversing this phenomenon, known as the Warburg effect, may offer a gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5465214a756732aa50594c44df14205d
https://doi.org/10.1158/0008-5472.c.6505976

Loss and gain of function of Grp75 or mitofusin 2 distinctly alter cholesterol metabolism, but all promote triglyceride accumulation in hepatocytes

Autor: Béatrice Morio, Arthur Bassot, Olivier Berdeaux, Stéphanie Cabaret, Johan Perrier, Emmanuelle Loizon, Anaïs Alves, Carina Prip-Buus, Jingwei Ji-Cao, Véronique Lenoir, Marie-Agnès Berger, Baptiste Panthu, Jennifer Rieusset

Publikováno v: Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, Elsevier, 2021, 1866 (12), pp.159030. ⟨10.1016/j.bbalip.2021.159030⟩

International audience; In the liver, contact sites between the endoplasmic reticulum (ER) and mitochondria (named MAMs) may be crucial hubs for the regulation of lipid metabolism, thus contributing to the exacerbation or prevention of fatty liver. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f00702701c8d068a19e4d34ba74ce9
https://hal.inrae.fr/hal-03325686