Dietary medium chain fatty acid supplementation leads to reduced VLDL lipolysis and uptake rates in comparison to linoleic acid supplementation.

Autor: Daniël B van Schalkwijk, Wilrike J Pasman, Henk F J Hendriks, Elwin R Verheij, Carina M Rubingh, Kees van Bochove, Wouter H J Vaes, Martin Adiels, Andreas P Freidig, Albert A de Graaf

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e100376 (2014)

Dietary medium chain fatty acids (MCFA) and linoleic acid follow different metabolic routes, and linoleic acid activates PPAR receptors. Both these mechanisms may modify lipoprotein and fatty acid metabolism after dietary intervention. Our objective

Externí odkaz: https://doaj.org/article/7af57f84a4024ad89ea5906228233bc8

Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes.

Autor: Suzan Wopereis, Carina M Rubingh, Marjan J van Erk, Elwin R Verheij, Trinette van Vliet, Nicole H P Cnubben, Age K Smilde, Jan van der Greef, Ben van Ommen, Henk F J Hendriks

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4525 (2009)

BACKGROUND: The prevalence of overweight is increasing globally and has become a serious health problem. Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Novel tools to understand thes

Externí odkaz: https://doaj.org/article/40933ed510724951b03118a8021bebc0

Metabolomic biomarkers for personalised glucose lowering drugs treatment in type 2 diabetes

Autor: Ilse K. Geerars-van Vonderen, Ben van Ommen, Linette Pellis, Henk den Ouden, Guy E.H.M. Rutten, Marjan van Erk, Joline W.J. Beulens, Carina M. Rubingh

Publikováno v: den Ouden, H, Pellis, L, Rutten, G E H M, Geerars-van Vonderen, I K, Rubingh, C M, van Ommen, B, van Erk, M J & Beulens, J W J 2016, ' Metabolomic biomarkers for personalised glucose lowering drugs treatment in type 2 diabetes ', Metabolomics, vol. 12, no. 2, 27, pp. 1-9 . https://doi.org/10.1007/s11306-015-0930-4
Metabolomics
Metabolomics, 12(2):27, 1-9
Metabolomics, 12(2). Springer New York

We aimed to identify metabolites to predict patients’ response to glucose lowering treatment during the first 5 years after detection of type 2 diabetes. Metabolites were measured by GC–MS in baseline samples from 346 screen-detected type 2 diabe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94dc2de499b738e2be3d24fdac3caeaf
https://research.vumc.nl/en/publications/461daab3-a258-4372-ae63-e232c0a0b1a8

Discovery of subtle effects in a human intervention trial through multilevel modeling

Autor: Suzan Wopereis, Henk F. J. Hendriks, Age K. Smilde, Nicole H.P. Cnubben, Elwin Verheij, T. van Vliet, B. van Ommen, Carina M. Rubingh, M. J. van Erk, J. van der Greef

Publikováno v: Chemometrics and Intelligent Laboratory Systems, 106(1), 108-114. Elsevier B.V
Chemometrics and Intelligent Laboratory Systems, 1, 106, 108-114

Many benefits can be gained if multi-factorial diseases with a high incidence and prevalence are better understood. Sophisticated approaches like multilevel analyses are needed to discover subtle differences between healthy people and people at the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b88a59e5487c3b94ea287e139ea142e
https://doi.org/10.1016/j.chemolab.2010.06.003

An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach

Autor: Linette Pellis, Suzan Wopereis, Marjan van Erk, H.F.J. Hendriks, Carina M. Rubingh, Teake Kooistra, Nicole H.P. Cnubben, Ben van Ommen, G.C.M. Bakker

Publikováno v: American Journal of Clinical Nutrition, 4, 91, 1044-1059

Background: Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development. Objective: It was hypothesized that specific dietary components are able to reduce low-grade inflammation as well as metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b332b34df0ec6336fd4ca7becc591688
https://doi.org/10.3945/ajcn.2009.28822