Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Carina Lemke"'
Autor:
Irene Pachón-Angona, Paul J. Bernard, Alexey Simakov, Maciej Maj, Krzysztof Jozwiak, Anna Novotna, Carina Lemke, Michael Gütschow, Helene Martin, María-Jesús Oset-Gasque, José-Marco Contelles, Lhassane Ismaili
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 121 (2024)
This work relates to the design and synthesis of a series of novel multi-target directed ligands (MTDLs), i.e., compounds 4a–l, via a convenient one-pot three-component Hantzsch reaction. This approach targeted calcium channel antagonism, antioxida
Externí odkaz:
https://doaj.org/article/91b84aaa929141c3b798a1c55836bddf
Autor:
Carina Lemke, Joscha Christmann, Jiafei Yin, José M. Alonso, Estefanía Serrano, Mourad Chioua, Lhassane Ismaili, María Angeles Martínez-Grau, Christopher D. Beadle, Tatiana Vetman, Florian M. Dato, Ulrike Bartz, Paul W. Elsinghorst, Markus Pietsch, Christa E. Müller, Isabel Iriepa, Timo Wille, José Marco-Contelles, Michael Gütschow
Publikováno v:
ACS Omega, Vol 4, Iss 26, Pp 22161-22168 (2019)
Externí odkaz:
https://doaj.org/article/266dc0bdc6b74364bac17b0fdeeb44a1
Autor:
Lorenzo Cianni, Carina Lemke, Erik Gilberg, Christian Feldmann, Fabiana Rosini, Fernanda Dos Reis Rocho, Jean F R Ribeiro, Daiane Y Tezuka, Carla D Lopes, Sérgio de Albuquerque, Jürgen Bajorath, Stefan Laufer, Andrei Leitão, Michael Gütschow, Carlos A Montanari
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 3, p e0007755 (2020)
The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. A series of 26 new compounds were designed, synthesized, and tested against the recombinant cruzain (Cz) to map it
Externí odkaz:
https://doaj.org/article/3510716dcbcc410e83482bb1244acca6
Publikováno v:
Bioorganic Chemistry. 138:106574
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dedf78bfb593b36b50253ff9c30ef3e8
https://doi.org/10.1016/j.bioorg.2023.106574
https://doi.org/10.1016/j.bioorg.2023.106574
Autor:
Lenka Ulrychová, Martin Horn, Carina Lemke, Michal Buša, Michael Gütschow, Dominik Brajtenbach, Jakub Benýšek, Christian Breuer, Katharina F. Kubatzky, Annika Illies, Adéla Jílková, Ulrike Bartz, Michael Mareš
Publikováno v:
Journal of Medicinal Chemistry. 64:13793-13806
The cysteine protease cathepsin K is a target for the treatment of diseases associated with high bone turnover. Cathepsin K is mainly expressed in osteoclasts and responsible for the destruction of the proteinaceous components of the bone matrix. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec972a79fa3c0ad74112d81cec9c59be
https://doi.org/10.1021/acs.jmedchem.1c01178
https://doi.org/10.1021/acs.jmedchem.1c01178
Autor:
Carina Lemke, Adéla Jílková, Dominic Ferber, Annett Braune, Anja On, Patrick Johe, Alena Zíková, Tanja Schirmeister, Michael Mareš, Martin Horn, Michael Gütschow
Publikováno v:
Chemistry – A European Journal. 28
Rhodesain is the major cysteine protease of the protozoan parasite Trypanosoma brucei and a therapeutic target for sleeping sickness, a fatal neglected tropical disease. We designed, synthesized and characterized a bimodal activity-based probe that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27d0522b3aa25a7d720c8994aa3d3b7
https://doi.org/10.1002/chem.202201636
https://doi.org/10.1002/chem.202201636
Autor:
Nina Geiger, Dominik Thimm, Thanigaimalai Pillaiyar, Robin Gedschold, Laura Schäkel, Michael Gütschow, Christa E. Müller, Ghazl Al Hamwi, Maria Zyulina, Vittoria Lopez, Christin Vielmuth, Katharina Sylvester, Miriam Diett, Lan Phuong Vu, Vigneshwaran Namasivayam, Julian Breidenbach, Anke C. Schiedel, Jochen Bodem, Salahuddin Mirza, Carina Lemke
Publikováno v:
Angewandte Chemie. 133:10515-10521
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ff9821b9fd888dcc360c6ff44e464c3
https://doi.org/10.1002/ange.202016961
https://doi.org/10.1002/ange.202016961
Autor:
Bianca Schulte, Maria König, Beate I. Escher, Sophie Wittenburg, Matic Proj, Valentina Wolf, Carina Lemke, Gregor Schnakenburg, Izidor Sosič, Hendrik Streeck, Christa E. Müller, Michael Gütschow, Christian Steinebach
Publikováno v:
ChemMedChem. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9279ed5c60907b98f58e135f8daec6b
https://doi.org/10.1002/cmdc.202200088
https://doi.org/10.1002/cmdc.202200088
Autor:
Christa E. Müller, Aliaa Abdelrahman, Solenne Rivière, Carina Lemke, Dirk Menche, Michael Gütschow, Christin Vielmuth, Christiane Ennenbach
Publikováno v:
Chemmedchem
The archazolids are potent antiproliferative compounds that have recently emerged as a novel class of promising anticancer agents. Their complex macrolide structures and scarce natural supply make the development of more readily available analogues h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7988f2b0f1c0ef9c098d4a9ff0ea00b6
http://europepmc.org/articles/PMC7496434
http://europepmc.org/articles/PMC7496434
Autor:
Bianca Schulte, Maria König, Beate I. Escher, Sophie Wittenburg, Matic Proj, Valentina Wolf, Carina Lemke, Gregor Schnakenburg, Izidor Sosič, Hendrik Streeck, Christa E. Müller, Michael Gütschow, Christian Steinebach
Publikováno v:
ChemMedChem. 17(5)
Naturally occurring compounds represent a vast pool of pharmacologically active entities. One of such compounds is andrographolide, which is endowed with many beneficial properties, including the activity against severe acute respiratory syndrome cor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfded0530b46ec39902492b95f7ff2f2
https://pubmed.ncbi.nlm.nih.gov/35099120
https://pubmed.ncbi.nlm.nih.gov/35099120