Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Carina Kärrman-Mårdh"'
Autor:
Tilia Selldén, Carina Kärrman Mårdh, Martin Joelsson, Jenny Vikgren, Åse Johnsson, Gunilla Larsson, Daniel Glinatsi, Kajsa Stubendorff, Karin Svensson, Inger Gjertsson, Anna Rudin, Anna-Carin Lundell, Anna-Karin Hultgård Ekwall
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-11 (2023)
Abstract Background The role of the lung for the initiation and progression of rheumatoid arthritis (RA) is still unclear. Up to 10% of RA patients develop interstitial lung disease which remains a clinical challenge. Understanding early disease mech
Externí odkaz:
https://doaj.org/article/c5ccc85712b34f399491eca71bd6825a
Autor:
Carina Kärrman Mårdh, James Root, Mohib Uddin, Kristina Stenvall, Anna Malmgren, Kostas Karabelas, Matthew Thomas
Publikováno v:
Journal of Immunology Research, Vol 2017 (2017)
Neutrophils are important effector cells of antimicrobial immunity in an acute inflammatory response, with a primary role in the clearance of extracellular pathogens. However, in respiratory diseases such as asthma and chronic obstructive pulmonary d
Externí odkaz:
https://doaj.org/article/33179958a831423e95c240354f2dc966
Autor:
Martijn L, Manson, Jesper, Säfholm, Anna, James, Anna-Karin, Johnsson, Per, Bergman, Mamdoh, Al-Ameri, Ann-Charlotte, Orre, Carina, Kärrman-Mårdh, Sven-Erik, Dahlén, Mikael, Adner
Publikováno v:
The Journal of allergy and clinical immunology. 145(3)
Specific inflammatory pathways are indicated to contribute to severe asthma, but their individual involvement in the development of airway hyperresponsiveness remains unexplored.This experimental study in human small bronchi aimed to provide insight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1518be51a3be65c5370459df5eee8f1e
https://pubmed.ncbi.nlm.nih.gov/31805312
https://pubmed.ncbi.nlm.nih.gov/31805312
Publikováno v:
Airway Cell Biology and Immunopathology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e14be45fd8c81f5fd75f480bf9d7c616
https://doi.org/10.1183/13993003.congress-2018.pa980
https://doi.org/10.1183/13993003.congress-2018.pa980
Autor:
Dong Yan, Robert Newton, Mark A. Giembycz, Mohammed O. Altonsy, Christopher F. Rider, Anthony N. Gerber, Suharsh Shah, Sarah Sasse, Mahmoud M. Mostafa, Anna Miller-Larsson, Carina Kärrman-Mårdh, Martijn L. Manson
Publikováno v:
Mol Pharmacol
In asthma, the clinical efficacy of inhaled corticosteroids (ICSs) is enhanced by long-acting β(2)-adrenoceptor agonists (LABAs). ICSs, or more accurately, glucocorticoids, promote therapeutically relevant changes in gene expression, and, in primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11efd5956ee68134fdedd5446a798bfc
https://hdl.handle.net/1887/3200938
https://hdl.handle.net/1887/3200938
Pharmacological Characterization of AZD5069, a Slowly Reversible CXC Chemokine Receptor 2 Antagonist
Autor:
Katherine Elisabeth Wiley, David J. Nicholls, Fraser MacIntosh, Alasdair Gaw, Caroline Phillips, Carina Kärrman Mårdh, I.A. Dainty
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 353:340-350
In normal physiologic responses to injury and infection, inflammatory cells enter tissue and sites of inflammation through a chemotactic process regulated by several families of proteins, including inflammatory chemokines, a family of small inducible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2679a13b8fe51b994df69ec7e35f6f15
https://doi.org/10.1124/jpet.114.221358
https://doi.org/10.1124/jpet.114.221358
Autor:
Veronica A. Swystun, Carin Jorup, Louis-Philippe Boulet, Carina Kärrman Mårdh, Gail M. Gauvreau, Kieran J. Killian, Beth E. Davis, Richard M. Watson, Richard Leigh, Francine Deschesnes, Donald W. Cockcroft, Paul M. O'Byrne, Magnus Aurivillius, Peter Wessman
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 191:161-167
Effective antiinflammatory therapies are needed for the treatment of asthma, but preferably without the systemic adverse effects of glucocorticosteroids.We evaluated the effect of an inhaled nonsteroidal glucocorticoid receptor agonist, AZD5423, on a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9610208a12345a4e22e3175fc035d914
https://doi.org/10.1164/rccm.201404-0623oc
https://doi.org/10.1164/rccm.201404-0623oc
Autor:
Markus Berger, Ramon Hendrickx, Martin Lindsjö, Stinabritt Nilsson, Tina Jellesmark Jensen, Tomas Klingstedt, Wayne Russell, Hartmut Rehwinkel, Martin Hemmerling, Thomas Hansson, Nafizal Hossain, Stefan Eirefelt, Balint Gabos, Henrik Johansson, Grigorios Nikitidis, Svetlana Ivanova, John Steele, Matti Lepistö, Eskil Johnsson, Anne-Helene Jansson, Anna Abrahamsson, Carina Kärrman Mårdh, Krister Henriksson, Jan Dahmén, Karl Edman, Anders Eriksson, Ulrika Tehler, Anders Jerre, Irene Mile, Lisa Wissler
Publikováno v:
Journal of medicinal chemistry. 60(20)
A class of potent, nonsteroidal, selective indazole ether-based glucocorticoid receptor modulators (SGRMs) was developed for the inhaled treatment of respiratory diseases. Starting from an orally available compound with demonstrated anti-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f24c66ce17b946cd661fe6628c9bfcc
https://pubmed.ncbi.nlm.nih.gov/28937774
https://pubmed.ncbi.nlm.nih.gov/28937774
Publikováno v:
Pharmaceutical research. 34(12)
A scientifically robust prediction of human dose is important in determining whether to progress a candidate drug into clinical development. A particular challenge for inhaled medicines is that unbound drug concentrations at the pharmacological targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db856c517abf31ede493f5de903e217
https://pubmed.ncbi.nlm.nih.gov/28685298
https://pubmed.ncbi.nlm.nih.gov/28685298
Autor:
Mark Berner Hansen, Daniel Muthas, Clare A. Balendran, Thomas T. MacDonald, Mohib Uddin, Tomas Ottosson, Gerhard Böttcher, Ib Groth Clausen, Carina Kärrman Mårdh, Anna Reznichenko, Silvio Danese
Publikováno v:
Scandinavian journal of gastroenterology. 52(2)
Objectives: This review article describes the role of neutrophils in mucosal injury and the resulting crypt abscesses characteristic of ulcerative colitis. We also review selected biomarkers for monitoring neutrophil presence and activity in the muco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed04f962f8b67f229496964f136cc1f
https://pubmed.ncbi.nlm.nih.gov/27610713
https://pubmed.ncbi.nlm.nih.gov/27610713