Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Carina I. Holmberg"'
Autor:
Giorgio Turconi, Farhan Alam, Tanima SenGupta, Sini Pirnes-Karhu, Soophie Olfat, Mark S. Schmidt, Kärt Mätlik, Ana Montaño-Rodriguez, Vladimir Heiskanen, Daniel Garton, Petteri T. Piepponen, Charles Brenner, Carina I. Holmberg, Hilde Nilsen, Eija Pirinen, Jaan-Olle Andressoo
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34355- (2024)
Parkinson's disease (PD) is associated with a reduction in 26/20S proteasome and mitochondrial function and depletion of dopamine. Activation of mitochondrial function with the NAD+ precursor nicotinamide riboside (NR) is a potential therapeutic for
Externí odkaz:
https://doaj.org/article/ac4f73d8f115461db81a3d5dd4a624da
Autor:
Johanna Pispa, Elisa Mikkonen, Leena Arpalahti, Congyu Jin, Carmen Martínez-Fernández, Julián Cerón, Carina I. Holmberg
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107886- (2023)
Summary: Polyubiquitinated proteins are primarily degraded by the ubiquitin-proteasome system (UPS). Proteasomes are present both in the cytoplasm and nucleus. Here, we investigated mechanisms coordinating proteasome subcellular localization and acti
Externí odkaz:
https://doaj.org/article/3bb1e6e66f7f4be6b4f447051eae7d00
Autor:
Carmen Martínez-Fernández, Sweta Jha, Elisabet Aliagas, Carina I. Holmberg, Ernest Nadal, Julián Cerón
Publikováno v:
Cells, Vol 12, Iss 6, p 929 (2023)
The deubiquitinase BAP1 (BRCA1-associated protein 1) is associated with BAP1 tumor predisposition syndrome (TPDS). BAP1 is a tumor suppressor gene whose alterations in cancer are commonly caused by gene mutations leading to protein loss of function.
Externí odkaz:
https://doaj.org/article/236ae986484849858475a150a525334b
Autor:
Diogo R. Feleciano, Katrin Juenemann, Manuel Iburg, Inês C. Brás, Carina I. Holmberg, Janine Kirstein
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
A functional protein quality control machinery is crucial to maintain cellular and organismal physiology. Perturbation in the protein homeostasis network can lead to the formation of misfolded and aggregated proteins that are a hallmark of protein co
Externí odkaz:
https://doaj.org/article/edb45883292f4b26948fa4d0fd6d07a9
Autor:
Sweta Jha, Carina I. Holmberg
Publikováno v:
Cells, Vol 9, Iss 8, p 1858 (2020)
The ubiquitin–proteasome system (UPS) and the autophagy–lysosomal pathway (ALP) are the two main eukaryotic intracellular proteolytic systems involved in maintaining proteostasis. Several studies have reported on the interplay between the UPS and
Externí odkaz:
https://doaj.org/article/8f22136cff804ca1b0ce87474cd9b6fe
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 1980-1995 (2013)
The proteasome plays an important role in proteostasis by carrying out controlled protein degradation in the cell. Impairments in proteasome function are associated with severe and often age-related diseases. Here, we have characterized a molecular m
Externí odkaz:
https://doaj.org/article/82a49a2664564224a07eef53499c5525
Publikováno v:
PLoS ONE, Vol 7, Iss 6 (2012)
Externí odkaz:
https://doaj.org/article/8b3cb7421dec4774b1bca2d72cacbc84
Autor:
Johanna Pispa, Elisa Mikkonen, Leena Arpalahti, Congyu Jin, Carmen Martínez-Fernández, Julián Cerón, Carina I. Holmberg
Regulated protein clearance is vital for cells to maintain protein homeostasis and the conditions essential for survival. The primary machinery for intracellular protein degradation is the ubiquitin– proteasome system (UPS), by which ubiquitin-tagg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39c4f8ecfb5ff1f6704215a54e03ca45
https://doi.org/10.1101/2022.10.03.510264
https://doi.org/10.1101/2022.10.03.510264
Publikováno v:
Cell Stress & Chaperones
Variation in ambient growth temperature can cause changes in normal animal physiology and cellular functions such as control of protein homeostasis. A key mechanism for maintaining proteostasis is the selective degradation of polyubiquitinated protei
Autor:
Jaan-Olle Andressoo, Farhan Alam, Giorgio Turconi, Kärt Mätlik, Tanima SenGupta, Soophie Olfat, Eija Pirinen, Mark S. Schmidt, Vladimir Heiskanen, Sini Pirnes-Karhu, Charles Brenner, Petteri Piepponen, Ana R. Montaño-Rodríguez, Hilde Nilsen, Carina I. Holmberg
Activation of mitochondrial metabolism and proteostasis with the NAD+ precursor nicotinamide riboside (NR) has emerged as a potential therapeutic approach for neurodegenerative disorders including Parkinson’s disease (PD). However, despite recently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3c84bbb14c5afe08fa713ba248867d4
https://doi.org/10.1101/2021.03.12.435062
https://doi.org/10.1101/2021.03.12.435062