Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Carina Höring"'
Autor:
Carina Höring, Marcus Conrad, Christian A. Söldner, Jinan Wang, Heinrich Sticht, Andrea Strasser, Yinglong Miao
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10047 (2021)
G protein-coupled receptors (GPCRs) are targets of extracellular stimuli and hence occupy a key position in drug discovery. By specific and not yet fully elucidated coupling profiles with α subunits of distinct G protein families, they regulate cell
Externí odkaz:
https://doaj.org/article/3fd1b6a9f3614a8d849c8510ffe9c43e
Autor:
Carina Höring, Ulla Seibel, Katharina Tropmann, Lukas Grätz, Denise Mönnich, Sebastian Pitzl, Günther Bernhardt, Steffen Pockes, Andrea Strasser
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8440 (2020)
In drug discovery, assays with proximal readout are of great importance to study target-specific effects of potential drug candidates. In the field of G protein-coupled receptors (GPCRs), the determination of GPCR-G protein interactions and G protein
Externí odkaz:
https://doaj.org/article/b106ab011dc5460da9eb1dce75d2e44c
Autor:
Ulrich Gergs, Carina Höring, Charlotte Fehse, Steffen Pockes, Maren Luise Büxel, Rebecca Schwarz, Uwe Kirchhefer, Margaréta Marušáková, Joachim Neumann, Britt Hofmann, Merlin Bresinsky, Aneta Čináková
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:223-234
In an integrative approach, we studied cardiac effects of recently published novel H2 receptor agonists in the heart of mice that overexpress the human H2 receptor (H2-TG mice) and littermate wild type (WT) control mice and in isolated electrically d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f2c0355e9482e1c32ea4d2630243ef8
https://doi.org/10.1124/jpet.121.000822
https://doi.org/10.1124/jpet.121.000822
Publikováno v:
Journal of Medicinal Chemistry. 63:13090-13102
Currently employed histamine H2 receptor (H2R) radioligands possess several drawbacks, for example, high non-specificity, insurmountable binding, or short half-life. We report the synthesis and the chemical and pharmacological characterization of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8915a09f7d4787c4c6058489196e0ff
https://doi.org/10.1021/acs.jmedchem.0c01494
https://doi.org/10.1021/acs.jmedchem.0c01494
Publikováno v:
Journal of medicinal chemistry. 63(21)
Currently employed histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8bb0f7dbbcc5824555083117d38f17b4
https://pubmed.ncbi.nlm.nih.gov/33108724
https://pubmed.ncbi.nlm.nih.gov/33108724
Autor:
Corinna G, Weinhart, David, Wifling, Maximilian F, Schmidt, Eduard, Neu, Carina, Höring, Timothy, Clark, Peter, Gmeiner, Max, Keller
Publikováno v:
European journal of medicinal chemistry. 213
The family of human muscarinic acetylcholine receptors (MRs) is characterized by a high sequence homology among the five subtypes (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9bbe903dbecad9172c0e6c7b6f384471
https://pubmed.ncbi.nlm.nih.gov/33571911
https://pubmed.ncbi.nlm.nih.gov/33571911
Autor:
Katarzyna, Szczepańska, Steffen, Pockes, Sabina, Podlewska, Carina, Höring, Kamil, Mika, Gniewomir, Latacz, Marek, Bednarski, Agata, Siwek, Tadeusz, Karcz, Martin, Nagl, Merlin, Bresinsky, Denise, Mönnich, Ulla, Seibel, Kamil J, Kuder, Magdalena, Kotańska, Holger, Stark, Sigurd, Elz, Katarzyna, Kieć-Kononowicz
Publikováno v:
European journal of medicinal chemistry. 213
A series of 4-pyridylpiperazine derivatives with varying regulatory region substituents proved to be potent histamine H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::714d1f27b2325a285b137f0d7134bbec
https://pubmed.ncbi.nlm.nih.gov/33261900
https://pubmed.ncbi.nlm.nih.gov/33261900
Autor:
Maximilian F. Schmidt, Corinna. G. Weinhart, Eduard Neu, David Wifling, Timothy Clark, Carina Höring, Max Keller, Peter Gmeiner
Publikováno v:
European Journal of Medicinal Chemistry. 213:113159
The family of human muscarinic acetylcholine receptors (MRs) is characterized by a high sequence homology among the five subtypes (M1R-M5R), being the reason for a lack of subtype selective MR ligands. In continuation of our work on dualsteric dibenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efd0060823339ab4f85a007125f3f8bc
https://doi.org/10.1016/j.ejmech.2021.113159
https://doi.org/10.1016/j.ejmech.2021.113159
Autor:
Agata Siwek, Katarzyna Szczepańska, Magdalena Kotańska, Marek Bednarski, Katarzyna Kieć-Kononowicz, Martin Nagl, Holger Stark, Tadeusz Karcz, Gniewomir Latacz, Steffen Pockes, Ulla Seibel, Merlin Bresinsky, Carina Höring, Kamil Kuder, Sabina Podlewska, Denise Mönnich, Sigurd Elz, Kamil Mika
Publikováno v:
European Journal of Medicinal Chemistry. 213:113041
A series of 4-pyridylpiperazine derivatives with varying regulatory region substituents proved to be potent histamine H3 receptor (H3R) ligands in the nanomolar concentration range. The most influential modification that affected the affinity toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fca7f022cdc2d7e2d9a511b84fc0bc9
https://doi.org/10.1016/j.ejmech.2020.113041
https://doi.org/10.1016/j.ejmech.2020.113041