Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Carina Fung"'
Autor:
Su Yin Lim, Sara Alavi, Zizhen Ming, Elena Shklovskaya, Carina Fung, Ashleigh Stewart, Helen Rizos
Publikováno v:
Biomedicines, Vol 9, Iss 6, p 605 (2021)
Immune checkpoint inhibitors that target the programmed cell death protein 1 (PD1) pathway have revolutionized the treatment of patients with advanced metastatic melanoma. PD1 inhibitors reinvigorate exhausted tumor-reactive T cells, thus restoring a
Externí odkaz:
https://doaj.org/article/927d20baade44743a32961f6b9e2d183
Autor:
Gulietta M. Pupo, Suzanah C. Boyd, Carina Fung, Matteo S. Carlino, Alexander M. Menzies, Bernadette Pedersen, Peter Johansson, Nicholas K. Hayward, Richard F. Kefford, Richard A. Scolyer, Georgina V. Long, Helen Rizos
Publikováno v:
Biomarker Research, Vol 5, Iss 1, Pp 1-4 (2017)
Abstract Alternate BRAF splicing is the most common mechanism of acquired resistance to BRAF inhibitor treatment in melanoma. Recently, alternate BRAF exon 4–8 splicing was shown to involve an intronic mutation, located 51 nucleotides upstream of B
Externí odkaz:
https://doaj.org/article/84e147d5245d4efc8c430efe2b83f592
Autor:
Adam Cisterne, Rana Baraz, Naveed I Khan, Robert Welschinger, Jordan Basnett, Carina Fung, Helen Rizos, Kenneth F Bradstock, Linda J Bendall
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103383 (2014)
Resistance to apoptosis remains a significant problem in drug resistance and treatment failure in malignant disease. NO-aspirin is a novel drug that has efficacy against a number of solid tumours, and can inhibit Wnt signaling, and although we have s
Externí odkaz:
https://doaj.org/article/beefc1bed07045eb9af5de5acabab1dd
Autor:
Georgina V. Long, Richard A. Scolyer, Richard F. Kefford, John F. Thompson, Robyn Saw, Julie Howle, Suzanah C. Boyd, Therese M. Becker, Branka Mijatov, Lauren E. Haydu, Jessica Hyman, Carina Fung, Matteo S. Carlino, Gulietta M. Pupo, Alexander M. Menzies, Helen Rizos
PDF file - 197KB, Table S1 Exome sequencing data summary. Table S2 Candidate resistant variants identified in Prog melanomas. Table S3 Median MAPK activity scores of Pre-treatment versus Prog melanoma metastases and associated P-value. Table S4 Gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691c31637feb577847ec995df5b0cc8b
https://doi.org/10.1158/1078-0432.22460846
https://doi.org/10.1158/1078-0432.22460846
Autor:
Helen Rizos, Georgina V. Long, Richard F. Kefford, Richard A. Scolyer, Adnan M. Nagrial, Mal Irvine, Suzanah C. Boyd, Jason R. Todd, Hamideh Shahheydari, Carina Fung, Matteo S. Carlino
Background: MEK1 mutations in melanoma can confer resistance to BRAF inhibitors, although preexisting MEK1P124 mutations do not preclude clinical responses. We sought to determine whether recurrent, preexisting MEK1P124 mutations affected clinical ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110ab1548d00d020ff420f208f11de0c
https://doi.org/10.1158/1078-0432.c.6522786
https://doi.org/10.1158/1078-0432.c.6522786
Autor:
Georgina V. Long, Richard A. Scolyer, Richard F. Kefford, John F. Thompson, Robyn Saw, Julie Howle, Suzanah C. Boyd, Therese M. Becker, Branka Mijatov, Lauren E. Haydu, Jessica Hyman, Carina Fung, Matteo S. Carlino, Gulietta M. Pupo, Alexander M. Menzies, Helen Rizos
PDF file - 427KB, Figure S1 Identification of BRAFV600E splice variants in Prog tumor derived from Patient 9. Figure S2 Representative Sanger sequencing traces. Figure S3 Level of V600E BRAF allele relative to the wild type BRAF allele. Figure S4 Lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1242a121df90897c82fb32056b7bd8
https://doi.org/10.1158/1078-0432.22460849
https://doi.org/10.1158/1078-0432.22460849
Autor:
Helen Rizos, Georgina V. Long, Richard F. Kefford, Richard A. Scolyer, Adnan M. Nagrial, Mal Irvine, Suzanah C. Boyd, Jason R. Todd, Hamideh Shahheydari, Carina Fung, Matteo S. Carlino
Supplementary Figures 1-5. S1 MEK1 P124 variants activate ERK1/2; S2 MEK1P124Q diminishes BRAF inhibitor sensitivity; S3 Effect of MEK1 mutations on MAPK and PI3K pathway signaling; S4 Identification of MEK1P124Q variant in the SMU030 cell line; S5 C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133911664742d3852007bcc120e15bbe
https://doi.org/10.1158/1078-0432.22454580.v1
https://doi.org/10.1158/1078-0432.22454580.v1
Autor:
Helen Rizos, Georgina V. Long, Richard F. Kefford, Richard A. Scolyer, Adnan M. Nagrial, Mal Irvine, Suzanah C. Boyd, Jason R. Todd, Hamideh Shahheydari, Carina Fung, Matteo S. Carlino
Supplementary Tables 1-5. S1 In silico evaluation of MEK1 Proline124 variants; S2 Correlation of factors and MEK1 mutation status; S3. Predictors of response to BRAF inhibition; S4. Univariate progression-free survival (PFS) according to MEK1 status;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423c2fb6fefd7c59faccace81d0c0948
https://doi.org/10.1158/1078-0432.22454577
https://doi.org/10.1158/1078-0432.22454577
Autor:
Helen Rizos, Georgina V. Long, Richard F. Kefford, Richard A. Scolyer, Adnan M. Nagrial, Mal Irvine, Suzanah C. Boyd, Jason R. Todd, Hamideh Shahheydari, Carina Fung, Matteo S. Carlino
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3623a9533a18ecfd0accdd3f57b114
https://doi.org/10.1158/1078-0432.22454586.v1
https://doi.org/10.1158/1078-0432.22454586.v1
Autor:
Carina Fung, Suzanah C. Boyd, Richard A. Scolyer, Peter Johansson, Gulietta M. Pupo, Richard F. Kefford, Nicholas K. Hayward, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Bernadette Pedersen, Helen Rizos
Publikováno v:
Biomarker Research, Vol 5, Iss 1, Pp 1-4 (2017)
Biomarker Research
Biomarker Research
Alternate BRAF splicing is the most common mechanism of acquired resistance to BRAF inhibitor treatment in melanoma. Recently, alternate BRAF exon 4–8 splicing was shown to involve an intronic mutation, located 51 nucleotides upstream of BRAF exon