Výsledky vyhledávání - "Carina Debes Marun"

Predicting Response of CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Acute Lymphoblastic Leukemia (ALL) and Aggressive Non-Hodgkin Lymphoma (NHL) in ACIT001/EXC002, a Phase Ib Clinical Trial

Autor: Bindu Thapa, Carina Debes-Marun, Zack M. Breckenridge, Irwindeep Sandhu, Andrew Daly, Faisal Khan, Michael P. Chu

Publikováno v: Blood. 140:12681-12682

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50073edd90ebff4de7451a7fcb575d73
https://doi.org/10.1182/blood-2022-165930

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Alberta Cellular and Immunotherapy (ACIT) 001, Results of Decentralized Production of Second Generation, Anti-CD19/41BB/CD3z Chimeric Antigen Receptor (CAR) T-Cells in Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL) and Aggressive Non-Hodgkin Lymphoma (NHL)

Autor: Michael P. Chu, Zack M. Breckenridge, Andrew Daly, Mona Shafey, Victor A. Lewis, Sunil J. Desai, Peng Wang, Joseph Brandwein, Peter Duggan, Beverly Wilson, Bindu Thapa, Carina Debes-Marun, Irwindeep Sandhu

Publikováno v: Blood. 140:7466-7467

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::134c9529f504fb71c10767ac0a2658cd
https://doi.org/10.1182/blood-2022-165887

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A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma

Autor: Tony Reiman, Julia Kirshner, Andrew Belch, Kyle J. Thulien, Linda M. Pilarski, Lorri D. Martin, Carina Debes Marun

Publikováno v: Blood. 112:2935-2945

Although the in vitro expansion of the multiple myeloma (MM) clone has been unsuccessful, in a novel three-dimensional (3-D) culture model of reconstructed bone marrow (BM, n = 48) and mobilized blood autografts (n = 14) presented here, the entire MM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaba12301a9303a939c11ae4ce424fd9
https://doi.org/10.1182/blood-2008-02-142430

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Frequent Occurrence of Highly Expanded but Unrelated B-Cell Clones in Patients with Multiple Myeloma

Autor: Jitra Kriangkum, James B. Johnston, Carina Debes Marun, Andrew R. Belch, Spencer B. Gibson, Sandrine Lafarge, Sarah N. Motz, Linda M. Pilarski, Christopher P. Venner

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 5, p e64927 (2013)

Clonal diversity in multiple myeloma (MM) includes both MM-related and MM-unrelated clonal expansions which are subject to dominance exerted by the MM clone. Here we show evidence for the existence of minor but highly expanded unrelated B-cell clones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5c0e11aeadbaf121424f94c372afa3
http://europepmc.org/articles/PMC3665682

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In multiple myeloma, bone-marrow lymphocytes harboring the same chromosomal abnormalities as autologous plasma cells predict poor survival

Autor: Carina Debes Marun, Andrew R. Belch, Linda M. Pilarski

Publikováno v: American Journal of Hematology

Chromosomal abnormalities in plasma cells (PCs) from multiple myeloma (MM) provide a clonal signature to identify malignant cells. BM-lymphocytes from MM aspirates, defined by stringent criteria, were screened for the same chromosomal abnormalities a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1da82d08b3db8efc27fdf924d437b4
https://pubmed.ncbi.nlm.nih.gov/22495885

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Second Clones In Molecularly-Defined Biclonal Multiple Myeloma Are Derived From Unrelated B Cells, Can Be Present at High Frequency and Exhibit Chromosomal Abnormalities

Autor: Jitra Kriangkum, Carina Debes Marun, Andrew R. Belch, Linda M. Pilarski, Sarah N. Motz

Publikováno v: Blood. 116:2981-2981

Abstract 2981 Typically MM involves a single monoclonal protein, predicting a single CDR3 peak. We have shown that a sizeable number of patients do not fit this pattern. RT-PCR and genomic PCR (gPCR) were performed using universal primers that bind t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc8551cad06ef681fa2a1f343a6373c2
https://doi.org/10.1182/blood.v116.21.2981.2981

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Molecular Biclonality: Analysis of Clonotypic IgH VDJ Reveals the Frequent Occurrence of a Second Clone in Multiple Myeloma

Autor: Jitra Kriangkum, Sarah N. Motz, Andrew R. Belch, Linda M. Pilarski, Carina Debes Marun

Publikováno v: Blood. 114:1813-1813

Abstract 1813 Poster Board I-839 Malignant clones in multiple myeloma (MM) express unique clonotypic VDJ sequences associated with the clinical isotype. It has been widely assumed that MM patients have only one clone. However, our analysis reveals th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6aa10d2bd276dc74f365ee8661cec0f
https://doi.org/10.1182/blood.v114.22.1813.1813

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A Unique Pre-Clinical Model Providing Access to a Drug Resistant Population within the Multiple Myeloma Stem Cell Niche in a Novel 3-D Culture System for Bone Marrow

Autor: Julia Kirshner, Tony Reiman, Andrew R. Belch, Carina Debes Marun, Lorri D. Martin, Linda M. Pilarski, Kyle J. Thulien

Publikováno v: Blood. 110:547-547

Bone marrow (BM), a site of hematopoiesis, is a multicellular tissue with a complex architecture. Multiple myeloma (MM) is an incurable plasma cell malignancy where even patients in remission succumb to an inevitable relapse. While considerable progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66ab86fbdfd27acefea59134cee5be35
https://doi.org/10.1182/blood.v110.11.547.547

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FISH and Chips: Novel, Point of Care Technology To Detect Chromosomal Abnormalities

Autor: Patrick M. Pilarski, Vincent J. Sieben, Christopher J. Backhouse, Carina Debes Marun, Linda M. Pilarski, Andrew R. Belch, Tony Reiman

Publikováno v: Blood. 108:3402-3402

Interphase fluorescence in situ hybridization (FISH) is widely used as a diagnostic tool for known genetic abnormalities due to its sensitivity for detection of cryptic aberrations, such as t(4;14)(p16;q32) in multiple myeloma (MM). In many cancers,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8a02792c9d98923cb2a5fac2348e36b
https://doi.org/10.1182/blood.v108.11.3402.3402

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