Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Carina Conzelmann"'
Autor:
Lukas Wettstein, Philip Maximilian Knaff, Christian Kersten, Patrick Müller, Tatjana Weil, Carina Conzelmann, Janis A Müller, Maximilian Brückner, Markus Hoffmann, Stefan Pöhlmann, Tanja Schirmeister, Katharina Landfester, Jan Münch, Volker Mailänder
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
This study describes the development and characterization of peptidomimetic inhibitors of TMPRSS2, which primes the Spike protein of SARS-CoV-2. The inhibitors are shown to prevent SARS-CoV-2 infection in cells as efficiently as camostat mesylate.
Externí odkaz:
https://doaj.org/article/1f0965b089714fc9bfce787fa886e9d3
Autor:
Alina Seidel, Eva-Maria Jacobsen, Dorit Fabricius, Magdalena Class, Maria Zernickel, Carmen Blum, Carina Conzelmann, Tatjana Weil, Rüdiger Groß, Sebastian F. N. Bode, Hanna Renk, Roland Elling, Maximillian Stich, Frank Kirchhoff, Klaus-Michael Debatin, Jan Münch, Aleš Janda
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
IntroductionDurability of immune protection against reinfection with SARS-CoV-2 remains enigmatic, especially in the pediatric population and in the context of immune-evading variants of concern. Obviously, this knowledge is required for measures to
Externí odkaz:
https://doaj.org/article/bc8842172d6a4f71844ef10e1613a2d4
Autor:
Caterina Prelli Bozzo, Rayhane Nchioua, Meta Volcic, Lennart Koepke, Jana Krüger, Desiree Schütz, Sandra Heller, Christina M. Stürzel, Dorota Kmiec, Carina Conzelmann, Janis Müller, Fabian Zech, Elisabeth Braun, Rüdiger Groß, Lukas Wettstein, Tatjana Weil, Johanna Weiß, Federica Diofano, Armando A. Rodríguez Alfonso, Sebastian Wiese, Daniel Sauter, Jan Münch, Christine Goffinet, Alberto Catanese, Michael Schön, Tobias M. Boeckers, Steffen Stenger, Kei Sato, Steffen Just, Alexander Kleger, Konstantin M. J. Sparrer, Frank Kirchhoff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entr
Externí odkaz:
https://doaj.org/article/45486c77950d4620853ea7ad4237e600
Autor:
Alina Seidel, Michelle Zanoni, Rüdiger Groß, Daniela Krnavek, Sümeyye Erdemci-Evin, Pascal von Maltitz, Dan P. J. Albers, Carina Conzelmann, Sichen Liu, Tatjana Weil, Benjamin Mayer, Markus Hoffmann, Stefan Pöhlmann, Alexandra Beil, Joris Kroschel, Frank Kirchhoff, Jan Münch, Janis A. Müller
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In light of the decreasing immune protection against symptomatic SARS-CoV-2 infection after initial vaccinations and the now dominant immune-evasive Omicron variants, ‘booster’ vaccinations are regularly performed to restore immune responses. Man
Externí odkaz:
https://doaj.org/article/ac9793b0bc7c48ab8e2e2d0c7a79653d
Autor:
Rüdiger Groß, Lívia Mesquita Dias Loiola, Leila Issmail, Nadja Uhlig, Valentina Eberlein, Carina Conzelmann, Lia‐Raluca Olari, Lena Rauch, Jan Lawrenz, Tatjana Weil, Janis A. Müller, Mateus Borba Cardoso, Andrea Gilg, Olivia Larsson, Urban Höglund, Sandra Axberg Pålsson, Anna Selch Tvilum, Kaja Borup Løvschall, Maria M. Kristensen, Anna‐Lena Spetz, Fortune Hontonnou, Marie Galloux, Thomas Grunwald, Alexander N. Zelikin, Jan Münch
Publikováno v:
Advanced Science, Vol 9, Iss 20, Pp n/a-n/a (2022)
Abstract Inhibitors of viral cell entry based on poly(styrene sulfonate) and its core–shell nanoformulations based on gold nanoparticles are investigated against a panel of viruses, including clinical isolates of SARS‐CoV‐2. Macromolecular inhi
Externí odkaz:
https://doaj.org/article/efb36e92da2449a5bac3fba657c93ca6
Autor:
Lukas Wettstein, Tatjana Weil, Carina Conzelmann, Janis A. Müller, Rüdiger Groß, Maximilian Hirschenberger, Alina Seidel, Susanne Klute, Fabian Zech, Caterina Prelli Bozzo, Nico Preising, Giorgio Fois, Robin Lochbaum, Philip Maximilian Knaff, Volker Mailänder, Ludger Ständker, Dietmar Rudolf Thal, Christian Schumann, Steffen Stenger, Alexander Kleger, Günter Lochnit, Benjamin Mayer, Yasser B. Ruiz-Blanco, Markus Hoffmann, Konstantin M. J. Sparrer, Stefan Pöhlmann, Elsa Sanchez-Garcia, Frank Kirchhoff, Manfred Frick, Jan Münch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically
Externí odkaz:
https://doaj.org/article/056726122e3545e6b5177624a1dc537a
Autor:
Jana Krüger, Rüdiger Groß, Carina Conzelmann, Janis A. Müller, Lennart Koepke, Konstantin M.J. Sparrer, Tatjana Weil, Desiree Schütz, Thomas Seufferlein, Thomas F.E. Barth, Steffen Stenger, Sandra Heller, Jan Münch, Alexander Kleger
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 935-948 (2021)
Background and aims: The COVID-19 pandemic has spread worldwide and poses a severe health risk. While most patients present mild symptoms, descending pneumonia can lead to severe respiratory insufficiency. Up to 50% of patients show gastrointestinal
Externí odkaz:
https://doaj.org/article/b59ed5beb9344b74a3e5846cda73c82d
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Since viral infectious diseases continue to be a global health threat, new antiviral drugs are urgently needed. A unique class of therapeutic compounds are antimicrobial peptides (AMPs). They can be found in humans, bacteria and plants. Plants expres
Externí odkaz:
https://doaj.org/article/546b9d9812584f478c48eddcda9abf10
Autor:
Rüdiger Groß, Michelle Zanoni, Alina Seidel, Carina Conzelmann, Andrea Gilg, Daniela Krnavek, Sümeyye Erdemci-Evin, Benjamin Mayer, Markus Hoffmann, Stefan Pöhlmann, Weimin Liu, Beatrice H. Hahn, Alexandra Beil, Joris Kroschel, Bernd Jahrsdörfer, Hubert Schrezenmeier, Frank Kirchhoff, Jan Münch, Janis A. Müller
Publikováno v:
EBioMedicine, Vol 75, Iss , Pp 103761- (2022)
Summary: Background: Heterologous COVID-19 vaccination regimens combining vector- and mRNA-based vaccines are already administered, but data on solicited adverse reactions, immunological responses and elicited protection are limited. Methods: To eval
Externí odkaz:
https://doaj.org/article/fcd33430a2d842e9bd5f10ff02995e22
Autor:
Maja C. Mezger, Carina Conzelmann, Tatjana Weil, Pascal von Maltitz, Dan P. J. Albers, Jan Münch, Thomas Stamminger, Eva-Maria Schilling
Publikováno v:
Viruses, Vol 14, Iss 6, p 1308 (2022)
Screening of a protein kinase inhibitor library identified SB431542, targeting activin receptor-like kinase 5 (ALK5), as a compound interfering with SARS-CoV-2 replication. Since ALK5 is implicated in transforming growth factor β (TGF-β) signaling
Externí odkaz:
https://doaj.org/article/31ab1fcea7894ab4bb95e84558ae3c0a