Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Carina C. Kern"'
Autor:
Carina C. Kern, Shivangi Srivastava, Marina Ezcurra, Kuei Ching Hsiung, Nancy Hui, StJohn Townsend, Dominik Maczik, Bruce Zhang, Victoria Tse, Viktoras Konstantellos, Jürg Bähler, David Gems
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract In post-reproductive C. elegans, destructive somatic biomass repurposing supports production of yolk which, it was recently shown, is vented and can serve as a foodstuff for larval progeny. This is reminiscent of the suicidal reproductive ef
Externí odkaz:
https://doaj.org/article/04171472277441768359127462819334
Autor:
Carina C. Kern, StJohn Townsend, Antoine Salzmann, Nigel B. Rendell, Graham W. Taylor, Ruxandra M. Comisel, Lazaros C. Foukas, Jürg Bähler, David Gems
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
It is unclear why C. elegans continues to produce large quantities of yolk after reproduction. Here the authors show that post-reproductive C. elegans mothers vent yolk which supports their offspring’s growth, serving as a form of primitive lactati
Externí odkaz:
https://doaj.org/article/055664668cb24b469c3a15be409762ad
Autor:
Carina C. Kern, David Gems
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The aging process in semelparous and iteroparous species is different, but how different? Death in semelparous organisms (e.g., Pacific salmon) results from suicidal reproductive effort (reproductive death). Aging (senescence) in iteroparous organism
Externí odkaz:
https://doaj.org/article/51ebc68642ec40f1828204ef2b883809
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In some species of salmon, reproductive maturity triggers the development of massive pathology resulting from reproductive effort, leading to rapid post-reproductive death. Such reproductive death, which occurs in many semelparous organisms (with a s
Externí odkaz:
https://doaj.org/article/9460a3f1517b483194adb6ff544adf25
Autor:
C. Angélica Pérez-Hernández, Carina C. Kern, Egle Butkeviciute, Elizabeth McCarthy, Hazel M. Dockrell, María Maximina Bertha Moreno-Altamirano, Bruno A. Aguilar-López, Gauri Bhosale, Hongyuan Wang, David Gems, Michael R. Duchen, Steven G. Smith, Francisco Javier Sánchez-García
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Monocytes can develop immunological memory, a functional characteristic widely recognized as innate immune training, to distinguish it from memory in adaptive immune cells. Upon a secondary immune challenge, either homologous or heterologous, trained
Externí odkaz:
https://doaj.org/article/48716dc62ad346e6aba33a1c45c1653e
Autor:
Aihan Zhang, Kuei Ching Hsiung, Carina C. Kern, Yuting Wang, Anna L. Girtle, Nuo Xu, David Gems
Publikováno v:
GeroScience.
Liposome-mediated delivery is a possible means to overcome several shortcomings with C. elegans as a model for identifying and testing drugs that retard aging. These include confounding interactions between drugs and the nematodes’ bacterial food s
Autor:
David Gems, Carina C. Kern
Publikováno v:
GeroScience. 44(5)
One of the most striking findings in biogerontology in the 2010s was the demonstration that elimination of senescent cells delays many late-life diseases and extends lifespan in mice. This implied that accumulation of senescent cells promotes late-li
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
In some species of salmon, reproductive maturity triggers the development of massive pathology resulting from reproductive effort, leading to rapid post-reproductive death. Such reproductive death, which occurs in many semelparous organisms (with a s
Autor:
Jürg Bähler, Graham W. Taylor, StJohn Townsend, Lazaros C. Foukas, Ruxandra M. Comisel, Nigel B. Rendell, Antoine Salzmann, Carina C. Kern, David Gems
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The nematode Caenorhabditis elegans exhibits rapid senescence that is promoted by the insulin/IGF-1 signalling (IIS) pathway via regulated processes that are poorly understood. IIS also promotes production of yolk for egg provisioning, which in post-
Autor:
Marina Ezcurra, Srivastava S, StJohn Townsend, Maczik D, Nancy Hui, Jürg Bähler, Carina C. Kern, David Gems, Tse
Ageing in the nematodeCaenorhabditis elegansis unusual in terms of the severity and early onset of senescent pathology, particularly affecting organs involved in reproduction (Ezcurra et al., 2018; Garigan et al., 2002; Herndon et al., 2002). In post
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b95ec08d91c84c066a2fa40f2c6e597d
https://doi.org/10.1101/2020.11.16.384255
https://doi.org/10.1101/2020.11.16.384255