Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Carina, Stiller"'
Autor:
Irene Bessi, Carina Stiller, Till Schroeder, Benedikt Schäd, Matthias Grüne, Julia Dietzsch, Claudia Höbartner
Publikováno v:
ACS Central Science, Vol 10, Iss 5, Pp 1084-1093 (2024)
Externí odkaz:
https://doaj.org/article/5a610193e0b640baa18b746933e2de3b
Autor:
Nicole Kleiber, Nicolas Lemus-Diaz, Carina Stiller, Marleen Heinrichs, Mandy Mong-Quyen Mai, Philipp Hackert, Ricarda Richter-Dennerlein, Claudia Höbartner, Katherine E. Bohnsack, Markus T. Bohnsack
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
RNA modifications are key regulators of RNA functions. Here, the authors identify METTL8 as the enzyme installing m3C32 in mitochondrial tRNAThr/Ser(UCN). Lack of these modifications affects tRNA structure and impairs mitochondrial translation.
Externí odkaz:
https://doaj.org/article/b66a7c73278d4acdb1a5947679641b80
Autor:
Goran Kokic, Patrick Cramer, Claudia Höbartner, Jana Schmitzová, Hauke S. Hillen, Carina Stiller, Christian Dienemann, Florian Kabinger
Publikováno v:
Nature Structural & Molecular Biology
Signal Transduction and Targeted Therapy
Nature Structural and Molecular Biology
Signal Transduction and Targeted Therapy
Nature Structural and Molecular Biology
Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bd1dd1116f1aefa1f2796c71819693
http://europepmc.org/articles/PMC8437801
http://europepmc.org/articles/PMC8437801
Autor:
Nicole, Kleiber, Nicolas, Lemus-Diaz, Carina, Stiller, Marleen, Heinrichs, Mandy Mong-Quyen, Mai, Philipp, Hackert, Ricarda, Richter-Dennerlein, Claudia, Höbartner, Katherine E, Bohnsack, Markus T, Bohnsack
Publikováno v:
Nature Communications
Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial matrix protein and active RNA methyltransferase responsible for installing m3C32 in the human mitochondrial (mt-)t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad1fbf0e95915065a0be5efabf499a99
https://pubmed.ncbi.nlm.nih.gov/35017528
https://pubmed.ncbi.nlm.nih.gov/35017528
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Deoxyribozymes are emerging as modification‐specific endonucleases for the analysis of epigenetic RNA modifications. Here, we report RNA‐cleaving deoxyribozymes that differentially respond to the presence of natural methylated cytidines, 3‐meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793c962d2ab2311cbf70cb582875e67f
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-254544
https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-254544
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
RNA‐cleaving deoxyribozymes can serve as selective sensors and catalysts to examine the modification state of RNA. However, site‐specific endonuclease deoxyribozymes that selectively cleave post‐transcriptionally modified RNA are extremely rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0db974891b7f28beb1bc374db0f36f53
Autor:
Sandra Gunesch, Erik Endres, Carina Stiller, Michael Decker, Matthias Hoffmann, Tangui Maurice, Matthias Scheiner, Christoph A. Sotriffer
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (20), pp.9116-9140. ⟨10.1021/acs.jmedchem.9b01012⟩
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (20), pp.9116-9140. ⟨10.1021/acs.jmedchem.9b01012⟩
In this study, the carbamate structure of pseudo-irreversible butyrylcholinesterase (BChE) inhibitors was optimized with regard to a longer binding to the enzyme. A set of compounds bearing different heterocycles (e.g., morpholine, tetrahydroisoquino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205747c4c766f3b32351b9b59c1f540d
https://pubmed.ncbi.nlm.nih.gov/31609115
https://pubmed.ncbi.nlm.nih.gov/31609115
Autor:
Anke Krueger, Claudia Fessele, Carina Stiller, Vijayanand Chandrasekaran, Thisbe K. Lindhorst, Stefan Wachtler
Publikováno v:
European Journal of Organic Chemistry. 2015:5519-5525
The study of bacterial adhesion is crucial to our understanding of infection processes as well as for the development of antiadhesives. Here we have investigated new nanodiamond glycoconjugates intended to inhibit adhesion of type 1 fimbriated E. col
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dce1145cc4f48daea26a12b8de5a4cfb
https://doi.org/10.1002/ejoc.201500532
https://doi.org/10.1002/ejoc.201500532
Autor:
Vijayanand Chandrasekaran, Anke Krueger, Claudia Fessele, Stefan Wachtler, Thisbe K. Lindhorst, Carina Stiller
Publikováno v:
European Journal of Organic Chemistry. 2015
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f1f802e13b4abd23ae3ab569bd5181
https://doi.org/10.1002/ejoc.201590070
https://doi.org/10.1002/ejoc.201590070
Autor:
Nicole Kleiber, Nicolas Lemus-Diaz, Carina Stiller, Marleen Heinrichs, Mandy Mong-Quyen Mai, Philipp Hackert, Ricarda Richter-Dennerlein, Claudia Höbartner, Katherine E. Bohnsack, Markus T. Bohnsack
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial matrix protein and active RNA methyltransferase responsible for installing m3C32 in the human mitochondrial (mt-)t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7f2d245cf6a953637192857a84e127