Výsledky vyhledávání - "Carin L. Perretta"

Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities

Autor: Carin L. Perretta, April Averill, Shaosong Chu, Robert Almassy, Stephen Margosiak, Jia Lu, Zhe Nie, Erickson Philip Eugene

Publikováno v: Bioorganicmedicinal chemistry letters. 18(2)

A series of macrocyclic derivatives has been designed and synthesized based on the X-ray co-crystal structures of pyrazolo[1,5-a] [1,3,5]triazines with corn CK2 (cCK2) protein. Bioassays demonstrated that these macrocyclic pyrazolo[1,5-a] [1,3,5]tria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f808ebafe4ac8e7b8eb58ad3f443947
https://pubmed.ncbi.nlm.nih.gov/18055206

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Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2

Autor: Robert Almassy, Stephen Margosiak, Kraig M. Yager, Shaosong Chu, Carin L. Perretta, April Averill, Erickson Philip Eugene, Zhe Nie, Jia Lu

Publikováno v: Bioorganicmedicinal chemistry letters. 17(15)

The structure-based design, synthesis, and anticancer activity of novel inhibitors of protein kinase CK2 are described. Using pyrazolo[1,5-a][1,3,5]triazine as the core scaffold, a structure-guided series of modifications provided pM inhibitors with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f2d545a2888fd96bc3548574040451
https://pubmed.ncbi.nlm.nih.gov/17540560

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