Výsledky vyhledávání - "Carin E G Havenith"

ADCT-301, a Pyrrolobenzodiazepine (PBD) Dimer–Containing Antibody–Drug Conjugate (ADC) Targeting CD25-Expressing Hematological Malignancies

Autor: Charles E. Britten, Paul W. H. I. Parren, Patrick Van Berkel, Michael Flynn, Conor S. Barry, John A. Hartley, Teresa Marafioti, Francesca Zammarchi, Peter Tyrer, Carin E. G. Havenith, David G. Williams, Francois D'Hooge, Luke Masterson, Arnaud C. Tiberghien, Philip Howard, Ayse U. Akarca, Jean-Noel Levy, Narinder Janghra

Publikováno v: Molecular Cancer Therapeutics. 15:2709-2721

Despite the many advances in the treatment of hematologic malignancies over the past decade, outcomes in refractory lymphomas remain poor. One potential strategy in this patient population is the specific targeting of IL2R-α (CD25), which is overexp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9c18ec05b256a78c3b4e29483e9c6e
https://doi.org/10.1158/1535-7163.mct-16-0233

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Pre-clinical pharmacology and mechanism of action of SG3199, the pyrrolobenzodiazepine (PBD) dimer warhead component of antibody-drug conjugate (ADC) payload tesirine

Autor: Arnaud C. Tiberghien, Francesca Zammarchi, Carin E. G. Havenith, Simon Chivers, Simon Corbett, Sajidah Chowdhury, Luke Masterson, Lauren Adams, John Bingham, Dyeison Antonow, Patrick Van Berkel, John A. Hartley, Shenlan Mao, Jay Harper, Michael Flynn, Halla W. Reinert, David G. Williams, Philip Howard

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports

Synthetic pyrrolobenzodiazepine (PBD) dimers, where two PBD monomers are linked through their aromatic A-ring phenolic C8-positions via a flexible propyldioxy tether, are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c638c52ec44956cb86e327d8149e2b51
https://doi.org/10.1038/s41598-018-28533-4

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ADCT-402, a PBD dimer-containing antibody drug conjugate targeting CD19-expressing malignancies

Autor: Francois D'Hooge, Teresa Marafioti, Patrick Van Berkel, Carin E. G. Havenith, Simon Chivers, Francesca Zammarchi, Arnaud C. Tiberghien, John A. Hartley, David G. Williams, Charles E. Britten, Konstantinos Kiakos, Lauren Adams, Peter Tyrer, Simon Corbett, Narinder Janghra, Philip Wilson Howard

Publikováno v: Blood. 131(10)

Human CD19 antigen is a 95-kDa type I membrane glycoprotein in the immunoglobulin superfamily whose expression is limited to the various stages of B-cell development and differentiation and is maintained in the majority of B-cell malignancies, includ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a665fdeacbce7d7bf5dccce01fffb022
https://pubmed.ncbi.nlm.nih.gov/29298756

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A Human CD4 Monoclonal Antibody for the Treatment of T-Cell Lymphoma Combines Inhibition of T-Cell Signaling by a Dual Mechanism with Potent Fc-Dependent Effector Activity

Autor: Joanne C. Cooper, Janine Schuurman, John C. Cambier, Carin E. G. Havenith, Jan G.J. vandeWinkel, David A. Rider, Paul W. H. I. Parren, Susanne Marschner, Ole Baadsgaard, Denis R. Alexander, Ruby de Ridder, Simon Walker, C. Favre

Publikováno v: Cancer Research. 67:9945-9953

Zanolimumab is a human IgG1 antibody against CD4, which is in clinical development for the treatment of cutaneous and nodal T-cell lymphomas. Here, we report on its mechanisms of action. Zanolimumab was found to inhibit CD4+ T cells by combining sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d8da7727676b1de041c180d4d38647d
https://doi.org/10.1158/0008-5472.can-07-1148

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Fc receptor but not complement binding is important in antibody protection against HIV

Autor: Paul W. H. I. Parren, Meredith Hunter, Caroline Lanigan, Carin E. G. Havenith, Lars Hangartner, Gary Landucci, Dennis R. Burton, Ann J. Hessell, Joost M. Bakker, Frank J. Beurskens, Preston A. Marx, Donald N. Forthal

Publikováno v: Nature. 449:101-104

Many effective vaccines act by inducing neutralizing antibodies, and this approach is a top priority in work on HIV vaccines. But a new study suggests that anti-HIV antibodies are most effective when they act in two ways: through neutralization — k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02921c9dcd7742fb8c6f7351de894bf7
https://doi.org/10.1038/nature06106

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Rat monocyte-derived dendritic cells function and migrate in the same way as isolated tissue dendritic cells

Autor: Carin E. G. Havenith, I. Mayen, C. D. Richters, R. H. J. Beelen, E. W. A. Kamperdijk

Publikováno v: Journal of Leukocyte Biology. 71:582-587

Dendritic cells (DC) are the most potent antigen-presenting cells and are therefore useful to induce immune responses against tumor cells in patients. DC can be generated in vitro from monocytes using GM-CSF and IL-4, the so-called monocyte-derived D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c658e25de24c6441ffd92ab157b0baf
https://doi.org/10.1189/jlb.71.4.582

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Better Preservation of Peritoneal Morphologic Features and Defense in Rats after Long-Term Exposure to a Bicarbonate/Lactate-Buffered Solution

Autor: Jacob van den Born, Inge L. Schadee-Eestermans, Inge de Greeuw, Piet M. ter Wee, Angelique G A Welten, L H Hekking, Robert H. J. Beelen, Dirk Faict, Bas A. J. Driesprong, Mohammad Zareie, Carin E. G. Havenith

Publikováno v: Journal of the American Society of Nephrology. 12:2775-2786

The long-term effects of a standard lactate-buffered dialysis fluid and a new, two-chamber, bicarbonate/lactate-buffered dialysis fluid (with fewer glucose degradation products and a neutral pH) were compared in an in vivo peritoneal exposure model.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d40d0ac9bb96f3a1576bb0e9b8a3a4a
https://doi.org/10.1681/asn.v12122775

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Dendritic cells and their precursors isolated from human bronchoalveolar lavage: immunocytologic and functional properties

Autor: Carin E. G. Havenith, Henk C. Hoogsteden, J. M. W. Van Haarst, Hemmo A. Drexhage, G. T. Verhoeven, H. J. De Wit

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 11:344-350

Human bronchoalveolar lavage (BAL) has been described to contain, besides a large number of alveolar macrophages (AM) (approximately 95%), small numbers of monocyte-like cells (approximately 2%) and dendritic cells (DC) (approximately 0.4%). To separ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a325c0be18d0d01f5932fe313bb98933
https://doi.org/10.1165/ajrcmb.11.3.8086170

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Separation of alveolar macrophages and dendritic cells via autofluorescence: phenotypical and functional characterizatior

Autor: Annette J. Breedijk, Nico Blijleven, Carin E. G. Havenith, Elisabeth C. M. Hoefsmit, P. P. M. C. van Miert, Wim Calame, Robert H. J. Beelen

Publikováno v: Journal of Leukocyte Biology. 53:504-510

In a previous study we demonstrated that an increase of monocytes and dendritic cells (MDC) was found in the bronchoalveolar lavage fluid (BAL) after intratracheal instillation of a bacillus Calmette-Guérin suspension. In the current study, the brig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0260a7dc832dddbff7982dcd98811604
https://doi.org/10.1002/jlb.53.5.504

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