Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Carin A.T.C. Lunenburg"'
1
Primary Care Prescription Drug Use and Related Actionable Drug‐Gene Interactions in the Danish Population
Autor: Carin A.T.C. Lunenburg, Kazi Ishtiak-Ahmed, Alexander S. Hauser, Christiane Gasse
Publikováno v: Clinical and Translational Science, Vol 13, Iss 4, Pp 798-806 (2020)
Lunenburg, C A T C, Hauser, A S, Ishtiak-Ahmed, K & Gasse, C 2020, ' Primary Care Prescription Drug Use and Related Actionable Drug-Gene Interactions in the Danish Population ', Clinical and Translational Science, vol. 13, no. 4, pp. 798-806 . https://doi.org/10.1111/cts.12768
Clinical and Translational Science
Pharmacogenetics (PGx) aims to improve drug therapy using the individual patients’ genetic make-up. Little is known about the potential impact of PGx on the population level, possibly hindering implementation of PGx in clinical care. Therefore, we
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e8a8b0f382fcc0fa3839b02a99cbe3
https://doaj.org/article/362ab91603e14200bbb61a4b9b2278db
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2
Life-time Actionable Pharmacogenetic Drug Use:A Population-based Cohort Study in 86 040 Young People with and without Mental Disorders in Denmark
Autor: Christiane Gasse, Thomas Werge, Carin A.T.C. Lunenburg, Kazi Ishtiak-Ahmed
Publikováno v: Lunenburg, C A T C, Ishtiak-Ahmed, K, Werge, T & Gasse, C 2022, ' Life-time Actionable Pharmacogenetic Drug Use : A Population-based Cohort Study in 86 040 Young People with and without Mental Disorders in Denmark ', Pharmacopsychiatry, vol. 55, no. 2, pp. 95-107 . https://doi.org/10.1055/a-1655-9500
Lunenburg, C A T C, Ishtiak-Ahmed, K, Werge, T & Gasse, C 2022, ' Life-time Actionable Pharmacogenetic Drug Use : A Population-based Cohort Study in 86 040 Young People With and Without Mental Disorders in Denmark ', Pharmacopsychiatry, vol. 55, no. 2, pp. 95-107 . https://doi.org/10.1055/a-1655-9500
Objective To describe life-time use of current actionable pharmacogenetic (PGx) somatic and psychotropic drugs according to international PGx consortia in people with and without hospital-diagnosed mental disorders in the Danish population. Methods P
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17db4ab5839b253a2ddd565eb85bc48a
https://curis.ku.dk/ws/files/311211877/a_1655_9500.pdf
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3
Pharmacogenetic genotype and phenotype frequencies in a large Danish population-based case-cohort sample
Autor: Anders D. Børglum, Christiane Gasse, Jonas Bybjerg-Grauholm, Janne P Thirstrup, David M. Hougaard, Preben Bo Mortensen, Thomas Werge, Ole Mors, Merete Nordentoft, Carin A.T.C. Lunenburg, Marie Bækvad-Hansen
Publikováno v: Lunenburg, C A T C, Thirstrup, J P, Bybjerg-Grauholm, J, Bækvad-Hansen, M, Hougaard, D M, Nordentoft, M, Werge, T, Børglum, A D, Mors, O, Mortensen, P B & Gasse, C 2021, ' Pharmacogenetic genotype and phenotype frequencies in a large Danish population-based case-cohort sample ', Translational Psychiatry, vol. 11, no. 1, 294 . https://doi.org/10.1038/s41398-021-01417-4
Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Pharmacogenetics aims to improve clinical care by studying the relationship between genetic variation and variable drug response. Large population-based datasets could improve our current understanding of pharmacogenetics from selected study populati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb08ea95cd8c806f2163f50e9dc9a643
https://pure.au.dk/portal/da/publications/pharmacogenetic-genotype-and-phenotype-frequencies-in-a-large-danish-populationbased-casecohort-sample(340fce32-4453-408a-8011-6c5926395550).html
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4
Pharmacogenetics in psychiatric care, a call for uptake of available applications
Autor: Carin A.T.C. Lunenburg, Christiane Gasse
Publikováno v: Lunenburg, C A T C & Gasse, C 2020, ' Pharmacogenetics in psychiatric care, a call for uptake of available applications ', Psychiatry Research, vol. 292, 113336 . https://doi.org/10.1016/j.psychres.2020.113336
In this narrative, we evaluate the role of pharmacogenetics in psychiatry from a pragmatic clinical perspective and address current barriers of clinical implementation of pharmacogenetics. Pharmacogenetics has been successfully implemented to improve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d06761f3c93cb1705be572a43d10f98
https://pubmed.ncbi.nlm.nih.gov/32739644
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6
A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy
Autor: Alexander L T Imholz, Jesse J. Swen, Marlène H.W. van de Poel, Albert J. ten Tije, Paul Hamberg, Annemieke Cats, Femke M. de Man, Jos H. Beijnen, Miriam Koopman, Vincent O. Dezentjé, Emma Kienhuis, Caroline M.P.W. Mandigers, Peter Nieboer, Linda M. Henricks, Didier Meulendijks, André B.P. van Kuilenburg, Carin A.T.C. Lunenburg, Geert W.J. Frederix, Jan H.M. Schellens, Hilde Rosing, Henk-Jan Guchelaar, Helga J. Droogendijk, Rob L. H. Jansen, Frank J.F. Jeurissen, Ron H.J. Mathijssen, Hans Gelderblom, Arnold Baars, Geert Jan Creemers, Johanna E.A. Portielje, Erik van Werkhoven, Ron H.N. van Schaik
Publikováno v: European Journal of Cancer, 107, 60. Elsevier Ltd
European Journal of Cancer, 107, 60. Elsevier Limited
European journal of cancer (Oxford, England, 107, 60-67. Elsevier Limited
European Journal of Cancer, 107, 60-67
European Journal of Cancer
European Journal of Cancer, 107, 60-67. Elsevier Ltd.
European Journal of Cancer, 107, 60-67. ELSEVIER SCI LTD
Background: Fluoropyrimidine therapy including capecitabine or 5-fluorouracil can result in severe treatment-related toxicity in up to 30% of patients. Toxicity is often related to reduced activity of dihydropyrimidine dehydrogenase, the main metabol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1847de5cbd772fe5bd914816205b488
https://dspace.library.uu.nl/handle/1874/389408
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7
DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis
Autor: Rob L. H. Jansen, Ron H.N. van Schaik, Henk-Jan Guchelaar, Johanna E.A. Portielje, Paul Hamberg, Didier Meulendijks, Jos H. Beijnen, Emma Kienhuis, Ron H.J. Mathijssen, Hans Gelderblom, Femke M. de Man, Frank J.F. Jeurissen, Geert W.J. Frederix, Arnold Baars, Jan H.M. Schellens, Helga J. Droogendijk, Marlène H.W. van de Poel, Hilde Rosing, Linda M. Henricks, Albert J. ten Tije, Annemieke Cats, Carin A.T.C. Lunenburg, Caroline M.P.W. Mandigers, Erik van Werkhoven, André B.P. van Kuilenburg, Peter Nieboer, Geert Jan Creemers, Miriam Koopman, Vincent O. Dezentjé, Alexander L T Imholz, Jesse J. Swen
Publikováno v: The Lancet Oncology, 19(11), 1459-1467
The Lancet Oncology, 19(11), 1459. Lancet Publishing Group
LANCET ONCOLOGY, 19(11), 1459. Lancet Publishing Group
The Lancet Oncology
Lancet oncology, 19(11), 1459-1467. Elsevier Science
lancet oncology, 19(11), 1459-1467. Lancet Publishing Group
Lancet Oncology, 19(11), 1459-1467. Lancet Publishing Group
Background Fluoropyrimidine treatment can result in severe toxicity in up to 30% of patients and is often the result of reduced activity of the key metabolic enzyme dihydropyrimidine dehydrogenase (DPD), mostly caused by genetic variants in the gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4283cc80c2ca08cc0f0a136e40a12b84
http://hdl.handle.net/1887/95617
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8
Diagnostic and therapeutic strategies for fluoropyrimidine treatment of patients carrying multiple DPYD variants
Autor: Hans Gelderblom, Carin A.T.C. Lunenburg, Henk-Jan Guchelaar, Linda M. Henricks, Jan H.M. Schellens, Jesse J. Swen, André B.P. van Kuilenburg, Ron H.J. Mathijssen
Publikováno v: Genes, 9(12):585. Multidisciplinary Digital Publishing Institute (MDPI)
Genes
Volume 9
Issue 12
Genes, 9(12)
Genes, Vol 9, Iss 12, p 585 (2018)
DPYD genotyping prior to fluoropyrimidine treatment is increasingly implemented in clinical care. Without phasing information (i.e., allelic location of variants), current genotype-based dosing guidelines cannot be applied to patients carrying multip
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de746e5ca0b4ccd0a1ce0350039aba6
https://doi.org/10.3390/genes9120585
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10
Standard fluoropyrimidine dosages in chemoradiation therapy result in an increased risk of severe toxicity in DPYD variant allele carriers
Autor: Linda M. Henricks, Hans Gelderblom, Femke P. Peters, Erika Cecchin, Henk-Jan Guchelaar, Giuseppe Toffoli, Jan H.M. Schellens, Jesse J. Swen, Eva Dreussi, Didier Meulendijks, Carin A.T.C. Lunenburg, Marta Fiocco
Publikováno v: Annals of Oncology. 29:viii187
Background Prospective DPYD genotyping prevents severe fluoropyrimidine (FP)-induced toxicity by decreasing dosages in DPYD variant allele carriers. FP dosages in chemoradiation therapy (CRT) are lower than those in other FP-containing regimens. Phar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7abfb7fa66425e306a32673569046b
https://doi.org/10.1093/annonc/mdy281.107
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