Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Carin A, Loewen"'
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 8, Iss 10, Pp 3331-3346 (2018)
G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
A screen for neuroprotective genes in Drosophila melanogaster led to the identification of a mutation that causes extreme, progressive loss of adult brain neuropil in conjunction with massive brain overgrowth. We mapped the mutation to the brain tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6982467c2a915173416df3c72b37baf
http://g3journal.org/lookup/doi/10.1534/g3.118.200627
http://g3journal.org/lookup/doi/10.1534/g3.118.200627
Autor:
Barry Ganetzky, Carin A. Loewen
Publikováno v:
Genetics. 208:1535-1552
Mitochondrial function requires coordinated activities of interacting proteins encoded in both the nuclear and mitochondrial genomes. Nuclear mutations cause human mitochondrial disorders that commonly exhibit unexplained clinical variability (e.g. a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e203ceb27a7f5f96f83a48154eb2fae5
https://doi.org/10.1534/genetics.118.300818
https://doi.org/10.1534/genetics.118.300818
Autor:
Carin A Loewen, Mel B Feany
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention. We u
Externí odkaz:
https://doaj.org/article/23961958d69a414db526747d032d1625
Autor:
Vikram Khurana, Ilan Elson-Schwab, Tudor A Fulga, Katherine A Sharp, Carin A Loewen, Erin Mulkearns, Jaana Tyynelä, Clemens R Scherzer, Mel B Feany
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001026 (2010)
Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's dise
Externí odkaz:
https://doaj.org/article/aac121ca1623427eb049dd57cbdfc71c
Autor:
Jason Pienaar, Stanislava Chtarbanova, Jesualdo Arturo Fuentes-González, Carin A. Loewen, Kathryn E. Hatchell, Olivia Gevedon, Shu Hui Lye, Lyndsey Bley, Keaton Schmitz, Harris Bolus
Publikováno v:
Journal of Visualized Experiments.
There is much to understand about the onset and progression of neurodegenerative diseases, including the underlying genes responsible. Forward genetic screening using chemical mutagens is a useful strategy for mapping mutant phenotypes to genes among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b209889fec31e45e18287a45d4775d
https://doi.org/10.3791/59720
https://doi.org/10.3791/59720
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Genetic variability affects the response to numerous xenobiotics but its role in the clinically-observed irregular responses to general anesthetics remains uncertain. To investigate the pharmacogenetics of volatile general anesthetics (VGAs), we deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8579575af44e5b9d469c48634b53dd14
http://europepmc.org/articles/PMC5799260
http://europepmc.org/articles/PMC5799260
Autor:
Carin A, Loewen, Barry, Ganetzky
Publikováno v:
Genetics. 208(4)
Proper mitochondrial activity depends upon proteins encoded by genes in the nuclear and mitochondrial genomes that must interact functionally and physically in a precisely coordinated manner. Consequently, mito-nuclear allelic interactions are though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e5d2c3c015aff990733c5a93b1eb83c3
https://pubmed.ncbi.nlm.nih.gov/29496745
https://pubmed.ncbi.nlm.nih.gov/29496745
Autor:
Rebeccah J, Katzenberger, Carin A, Loewen, R Tayler, Bockstruck, Mikal A, Woods, Barry, Ganetzky, Barry, Ganetky, David A, Wassarman
Publikováno v:
Journal of visualized experiments : JoVE. (100)
Traumatic brain injury (TBI) affects millions of people each year, causing impairment of physical, cognitive, and behavioral functions and death. Studies using Drosophila have contributed important breakthroughs in understanding neurological processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2b77ed757f5a6c68901a268710433af1
https://pubmed.ncbi.nlm.nih.gov/26207663
https://pubmed.ncbi.nlm.nih.gov/26207663
Autor:
Barry Ganetzky, R. Tayler Bockstruck, Mikal A. Woods, David A. Wassarman, Carin A. Loewen, Rebeccah J. Katzenberger
Publikováno v:
Journal of Visualized Experiments.
Traumatic brain injury (TBI) affects millions of people each year, causing impairment of physical, cognitive, and behavioral functions and death. Studies using Drosophila have contributed important breakthroughs in understanding neurological processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f52a3314acc0ff88819b4965b18215
https://doi.org/10.3791/52905
https://doi.org/10.3791/52905
Publikováno v:
The Journal of Comparative Neurology. 496:1-12
Synaptotagmin I is a synaptic vesicle protein postulated to mediate vesicle docking, vesicle recycling, and the Ca(2+) sensing required to trigger vesicle fusion. Analysis of synaptotagmin I knockouts (sytI(NULL) mutants) in both Drosophila and mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83551ead175e6ff2c6089974cd721f12
https://doi.org/10.1002/cne.20868
https://doi.org/10.1002/cne.20868