Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Carey L. Watson"'
Autor:
Stacy R. Finkbeiner, David R. Hill, Christopher H. Altheim, Priya H. Dedhia, Matthew J. Taylor, Yu-Hwai Tsai, Alana M. Chin, Maxime M. Mahe, Carey L. Watson, Jennifer J. Freeman, Roy Nattiv, Matthew Thomson, Ophir D. Klein, Noah F. Shroyer, Michael A. Helmrath, Daniel H. Teitelbaum, Peter J. Dempsey, Jason R. Spence
Publikováno v:
Stem Cell Reports, Vol 4, Iss 6, Pp 1140-1155 (2015)
Human intestinal organoids (HIOs) are a tissue culture model in which small intestine-like tissue is generated from pluripotent stem cells. By carrying out unsupervised hierarchical clustering of RNA-sequencing data, we demonstrate that HIOs most clo
Externí odkaz:
https://doaj.org/article/e58d3f621aa14933b2e1b3f5d4737ffd
Autor:
Yuichiro Miyaoka, Nambirajan Sundaram, Edouard G. Stanley, Philippe Aubert, Mohammad A. Mandegar, Michael J. Workman, Michael A. Helmrath, Carey L. Watson, Holly M. Poling, Samantha A. Brugmann, Ching-Fang Chang, Jacqueline V. Schiesser, Andrew G. Elefanty, James M. Wells, Maxime M. Mahe, Stephen L. Trisno, Michel Neunlist, Bruce R. Conklin
Publikováno v:
Nature Medicine. 23:49-59
The enteric nervous system (ENS) of the gastrointestinal tract controls many diverse functions, including motility and epithelial permeability. Perturbations in ENS development or function are common, yet there is no human model for studying ENS-inte
Autor:
Nambirajan Sundaram, Jason R. Spence, Michael A. Helmrath, Jorge O. Múnera, Jonathan R. Hudson, David E. Hill, Maxime M. Mahe, James M. Wells, Aaron M. Zorn, Carey L. Watson, Jonathan C. Howell, Jefferson E. Vallance, Praneet Chatuvedi, Katie L. Sinagoga, Scott A. Rankin, Adrian Zarzoso-Lacoste, Noah F. Shroyer, John M. Shannon
Publikováno v:
Cell Stem Cell
Cell Stem Cell, Cambridge, MA : Cell Press, 2019, 24 (5), pp.829. ⟨10.1016/j.stem.2017.05.020⟩
Cell Stem Cell, Cambridge, MA : Cell Press, 2019, 24 (5), pp.829. ⟨10.1016/j.stem.2017.05.020⟩
Gastric and small intestinal organoids differentiated from human pluripotent stem cells (hPSCs) have revolutionized the study of gastrointestinal development and disease. Distal gut tissues such as cecum and colon, however, have proven considerably m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b424c86dcf566cbbe4e75aaffa47c7f2
https://hal.archives-ouvertes.fr/hal-02533282
https://hal.archives-ouvertes.fr/hal-02533282
Autor:
Carey L. Watson, Swathi Balaji, Paul L. Bollyky, Sundeep G. Keswani, Rajeev Ranjan, Alice King
Publikováno v:
Advances in Wound Care. 4:660-672
Significance: Fetal wounds heal with a regenerative phenotype that is indistinguishable from surrounding skin with restored skin integrity. Compared to this benchmark, all postnatal wound healing is impaired and characterized by scar formation. The b
Autor:
Jacob R. Enriquez, Carey L. Watson, Heather A. McCauley, Nichole A. Reynolds, Hsiu-Chiung Yang, Katie L. Sinagoga, Jorge O. Múnera, James M. Wells, Michael A. Helmrath
Enteroendocrine cells (EECs) are a minor cell population in the intestine yet they play a major role in digestion, satiety and nutrient homeostasis. Recently developed human intestinal organoid models include EECs, but their rarity makes it difficult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39b72287aabaec973a8abcecef0f048
https://europepmc.org/articles/PMC6198470/
https://europepmc.org/articles/PMC6198470/
Autor:
Shaheel Mitra, Timothy M. Crombleholme, Carey L. Watson, Alice King, Aimen F. Shaaban, Brad W. Warner, Sundeep G. Keswani, Michael J. Morowitz, Allan M. Goldstein
Publikováno v:
Journal of Pediatric Surgery. 50:1049-1052
Background: The factors that contribute to success as a pediatric surgeon–scientist are not well defined. The purpose of this study is to define a group of NIH-funded pediatric surgeons, assess their academic productivity, and elucidate factors tha
Publikováno v:
Diabetes
Neurogenin3 (NEUROG3) is a basic helix-loop-helix transcription factor required for development of the endocrine pancreas in mice. In contrast, humans with NEUROG3 mutations are born with endocrine pancreas function, calling into question whether NEU
Autor:
Akihiro Asai, James A. Wells, Michael A. Helmrath, Tatsuki Mizuochi, Eitaro Aihara, Christopher N. Mayhew, Jorge A. Bezerra, Kieran J. Phelan, Pranavkumar Shivakumar, Reena Mourya, Takanori Takebe, Carey L. Watson
Publikováno v:
Development.
A self-organizing organoid model provides a new approach to study the mechanism of human liver organogenesis. Previous animal models documented that simultaneous paracrine signaling and cell-to-cell surface contact regulate hepatocyte differentiation
Autor:
Christopher N. Mayhew, Hansraj Bangar, Na Li, Sang-Wook Cha, Shila Gilbert, Michael A. Helmrath, Ruixue Liu, Carey L. Watson, Hai Bin Ruan, James A. Wells, Richard Moriggl, David B. Haslam, Dongsheng Zhang, Haitao Niu, Xiaonan Han, Lee A. Denson, Rebekah Karns, Tongli Zhang, Haifeng Li
Publikováno v:
Life Science Alliance
STAT5 controls the intestinal epithelial stem cell niche by regulating Wnt/β-catenin signaling, and lack of active pYSTAT5 induces Clostridium difficile infection. STAT5 may be a transcription factor that restricts niche cell differentiation.
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Publikováno v:
Journal of Visualized Experiments : JoVE
The epithelium of the gastrointestinal tract is constantly renewed as it turns over. This process is triggered by the proliferation of intestinal stem cells (ISCs) and progeny that progressively migrate and differentiate toward the tip of the villi.