Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1

Autor: Darshika J. Udawatte, Diane M. Lang, Jeffrey R. Currier, Carey L. Medin, Alan L. Rothman

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Dengue virus (DENV) infection is the most prevalent arthropod-borne virus disease and is endemic in more than 100 countries. Several DENV proteins have been shown to target crucial human host proteins to evade innate immune responses and establish a

Externí odkaz: https://doaj.org/article/3e941e44a5074e25b21bc5f328d39f76

Analysis of the TCR Repertoire in HIV-Exposed but Uninfected Infants

Autor: Ruth Nduati, Benjamin Gabriel, Rose Bosire, Barbara Lohman-Payne, Grace John-Stewart, Carey Farquhar, Jeremiah Alves, Dalton Wamalwa, Carey L. Medin

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports

Maternal human immunodeficiency virus (HIV) infection has been shown to leave profound and lasting impacts on the HIV-exposed uninfected (HEU) infant, including increased mortality and morbidity, immunological changes, and developmental delays compar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224a48119537868385c8d89429a140b3
http://link.springer.com/article/10.1038/s41598-019-48434-4

Functional Characterization of Murine Interferon Regulatory Factor 5 (IRF-5) and Its Role in the Innate Antiviral Response

Autor: Mumtaz Yaseen Balkhi, Katherine A. Fitzgerald, Paula M. Pitha, Carey L. Medin, Jorgen T. Reinert, Andrea Paun, Zhaozhao Jiang

Publikováno v: Paun, A, Reinert, T, Jiang, Z, Medin, C, Balkhi, M Y, Fitzgerald, K A & Pitha, P M 2008, ' Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response ', Journal of Biological Chemistry, vol. 283, no. 21, pp. 14295-308 . https://doi.org/10.1074/jbc.M800501200

Although the role of human IRF-5 in antiviral and inflammatory responses in vitro has been well characterized, much remains to be elucidated about murine IRF-5. Murine IRF-5, unlike the heavily spliced human gene, is primarily expressed as a full-len

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3d528c8812ddd40f4ead5bdb0c0403
https://doi.org/10.1074/jbc.m800501200

Immunopathogenesis Versus Protection in Dengue Virus Infections

Autor: Jeffrey R. Currier, Carey L. Medin, Heather Friberg, Alan L. Rothman

Dengue viruses (DENV) are mosquito-borne viruses that cause significant morbidity. The existence of four serotypes of DENV with partial immunologic cross-reactivity creates the opportunity for individuals to experience multiple acute DENV infections

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e8fb42f1a13e062428439d9195e21d
https://europepmc.org/articles/PMC4036645/

Cell type-specific mechanisms of interleukin-8 induction by dengue virus and differential response to drug treatment

Autor: Carey L. Medin, Alan L. Rothman

Publikováno v: The Journal of infectious diseases. 193(8)

In vitro infection with dengue virus induces interleukin (IL)-8 secretion, which increases endothelial cell permeability; this has been proposed as a mechanism for plasma leakage in dengue hemorrhagic fever. We studied the mechanisms of IL-8 inductio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e96012f83ecc725391a9bd39d369878
https://pubmed.ncbi.nlm.nih.gov/16544247