Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Carey K. Bagdassarian"'
Autor:
Fatima Quddos, Patty Zwollo, Lauren Abderhalden, Carey K. Bagdassarian, Meredith Evans Seeley, Robert C. Hale
Publikováno v:
Fishshellfish immunology. 114
Environmental microplastic pollution (including polystyrene, PS) may have detrimental effects on the health of aquatic organisms. Accumulation of PS microplastics has been reported to affect innate immune cells and inflammatory responses in fish. To
Publikováno v:
The Journal of Physical Chemistry B. 107:12527-12533
This work explores dynamical couplings between global enzymatic fluctuation patterns and the catalytic fitness of a model enzyme system. A genetic algorithm drives the evolution of a population of enzyme molecules toward greater catalytic fitness by
Autor:
G. S. Blair Williams, David E. Kranbuehl, Shiying Shang, Carey K. Bagdassarian, Aftab M. Hossain
Publikováno v:
Journal of Theoretical and Computational Chemistry. :323-334
Possible causal connections between the dynamics of a thermally fluctuating model enzyme molecule and catalysis are explored. The model is motivated by observations from experiment and simulation that amino acid residues residing in different enzymat
Autor:
Carey K. Bagdassarian, Kutay O. Alper
Publikováno v:
Journal of Theoretical and Computational Chemistry. :45-52
An algorithm is presented for projecting — at the amino acid level — the three-dimensional crystal structure of a protein molecule onto a planar surface. The scheme is topologically consistent: if two amino acid residues are closely juxtaposed in
Publikováno v:
Protein Science. 11:1424-1434
Analysis of the crystal structures for cytidine deaminase complexed with substrate analog 3-deazacytidine, transition-state analog zebularine 3,4-hydrate, and product uridine establishes significant changes in the magnitude of atomic-scale fluctuatio
Publikováno v:
Annual Review of Pharmacology and Toxicology. 41:661-690
Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2α, PGI2, TxA2, and PGD2. These autacrine lipid mediators interact with specific members of a family of distinct G-protein-coupled prostanoid receptors, designated EP, FP,
Publikováno v:
Biophysical Journal. 79:1180-1187
The association of two species to form a bound complex, e.g., the binding of a ligand to a protein or the adsorption of a peptide on a lipid membrane, involves an entropy loss, reflecting the conversion of free translational and rotational degrees of
Publikováno v:
International Journal of Quantum Chemistry. 78:195-204
Quantum mechanical molecular electrostatic potential surfaces and neural networks are combined to predict the binding energy for bioactive molecules with enzyme targets. Computational neural networks are employed to identify the quantum mechanical fe
Publikováno v:
Biochemistry. 37:8615-8621
Genetic defects in human purine nucleoside phosphorylase cause T-cell deficiency as the major phenotype. It has been proposed that efficient inhibitors of the enzyme might intervene in disorders of T-cell function. Compounds with features of the tran
Publikováno v:
Biochemistry. 37:3876-3885
The pre-steady-state kinetics of the half-reactions of several substrates with dialkylglycine decarboxylase are examined by multiwavelength kinetics and global analysis. The substrates examined fall into two groups: those that exhibit simple, monopha