Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Caren Norden"'
Autor:
Qian Wu, Euclides Sacomboio, Lara Valente de Souza, Rui Martins, Jamil Kitoko, Sílvia Cardoso, Temitope W. Ademolue, Tiago Paixão, Jaakko Lehtimäki, Ana Figueiredo, Caren Norden, Pierre-Louis Tharaux, Guenter Weiss, Fudi Wang, Susana Ramos, Miguel P. Soares
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112057- (2023)
Summary: Iron recycling prevents the development of anemia under homeostatic conditions. Whether iron recycling was co-opted as a defense strategy to prevent the development of anemia in response to infection is unclear. We find that in severe Plasmo
Externí odkaz:
https://doaj.org/article/b51c6269e0044623b4090c20d9799e29
Autor:
Henrike Indrischek, Juliane Hammer, Anja Machate, Nikolai Hecker, Bogdan Kirilenko, Juliana Roscito, Stefan Hans, Caren Norden, Michael Brand, Michael Hiller
Publikováno v:
eLife, Vol 11 (2022)
Despite decades of research, knowledge about the genes that are important for development and function of the mammalian eye and are involved in human eye disorders remains incomplete. During mammalian evolution, mammals that naturally exhibit poor vi
Externí odkaz:
https://doaj.org/article/401fc606f4a84ae2a09373993f44d03c
Autor:
Rana Amini, Archit Bhatnagar, Raimund Schlüßler, Stephanie Möllmert, Jochen Guck, Caren Norden
Publikováno v:
eLife, Vol 11 (2022)
Migration of cells in the developing brain is integral for the establishment of neural circuits and function of the central nervous system. While migration modes during which neurons employ predetermined directional guidance of either preexisting neu
Externí odkaz:
https://doaj.org/article/7b965a55cc104aba9d91966ee91f212f
Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway
Publikováno v:
eLife, Vol 9 (2020)
During brain development, progenitor cells need to balanceproliferation and differentiation in order to generate different neurons in the correct numbers and proportions. Currently, the patterns of multipotent progenitor divisions that lead to neurog
Externí odkaz:
https://doaj.org/article/a8aeb3f98235463d9dbed438a01236cf
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Current approaches to conditionally deplete target proteins require site-specific genetic engineering or have poor temporal control. Here the authors overcome these limitations by combining the AID system with nanobodies to reversibly degrade GFP-tag
Externí odkaz:
https://doaj.org/article/a7c05273d2474b3cb400cd105f73eb4a
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006018 (2018)
Tissue shape is often established early in development and needs to be scaled isotropically during growth. However, the cellular contributors and ways by which cells interact tissue-wide to enable coordinated isotropic tissue scaling are not yet unde
Externí odkaz:
https://doaj.org/article/d402ba63289b41caa1b12735c42d2284
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2018)
In the retina, like in most other brain regions, developing neurons are arranged into distinct layers giving the mature tissue its stratified appearance. This process needs to be highly controlled and orchestrated, as neuronal layering defects lead t
Externí odkaz:
https://doaj.org/article/6abba82d57d04a5d88e56377690b5482
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 168-182 (2015)
In animal cells, supernumerary centrosomes, resulting from centriole amplification, cause mitotic aberrations and have been associated with diseases, including microcephaly and cancer. To evaluate how centriole amplification impacts organismal develo
Externí odkaz:
https://doaj.org/article/e9fe70423d254f91a5d6eb2f74968ec3
Autor:
Jaydeep Sidhaye, Caren Norden
Publikováno v:
eLife, Vol 6 (2017)
Organ formation is a multi-scale event that involves changes at the intracellular, cellular and tissue level. Organogenesis often starts with the formation of characteristically shaped organ precursors. However, the cellular mechanisms driving organ
Externí odkaz:
https://doaj.org/article/e12265092fb14138a1ea791e2ad50a96
Autor:
Isabell P. Weber, Ana P. Ramos, Paulina J. Strzyz, Louis C. Leung, Stephen Young, Caren Norden
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 386-397 (2014)
Summary: The development of complex neuronal tissues like the vertebrate retina requires the tight orchestration of cell proliferation and differentiation. Although the complexity of transcription factors and signaling pathways involved in retinogene
Externí odkaz:
https://doaj.org/article/6f0dfc97df4141d19721d15a587b85d8