Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Caren M. Gundberg"'
Autor:
Muriel E. Babey, Susan K. Ewing, Elsa S. Strotmeyer, Nicola Napoli, Anne L. Schafer, Eric Vittinghoff, Caren M. Gundberg, Ann V. Schwartz
Publikováno v:
Journal of Bone and Mineral Research. 37:876-884
Mouse models suggest that undercarboxylated osteocalcin (ucOC), produced by the skeleton, protects against type 2 diabetes development, whereas human studies have been inconclusive. We aimed to determine if ucOC or total OC is associated with inciden
Autor:
Sabine R Zwakenberg, Caren M Gundberg, Annemieke M W Spijkerman, Daphne L van der A, Yvonne T van der Schouw, Joline W J Beulens
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138693 (2015)
To investigate whether total osteocalcin (tOC), uncarboxylated osteocalcin (ucOC) and percentage of uncarboxylated osteocalcin (%ucOC) are associated with the risk of type 2 diabetes.This nested case control study included 1,635 participants, 833 inc
Externí odkaz:
https://doaj.org/article/975f3e52ff014d219602953a168673a1
Publikováno v:
Annals of the New York Academy of Sciences. 1409:79-84
Osteocalcin (OC) and osteopontin (OPN) are major non-collagenous proteins (NCPs) involved in bone matrix organization and deposition. In spite of this, it is currently unknown whether OC and OPN alter bone morphology and consequently affect bone frac
Publikováno v:
Analytical Biochemistry. 525:46-53
Osteocalcin is an important extracellular matrix bone protein that contributes to the structural properties of bone through its interactions with hydroxyapatite mineral and with collagen I. This role may be affected by glycation, a labile modificatio
Publikováno v:
Journal of Bone and Mineral Research. 32:243-249
Osteocalcin (OC) is a vitamin K-dependent protein synthesized during bone formation. Mice injected with the undercarboxylated form of OC (ucOC) had more skeletal muscle mass and less fat mass than sham-treated controls, suggesting a unique metabolic
Publikováno v:
Rapid Communications in Mass Spectrometry. 30:2109-2115
Rationale Osteocalcin is a small, abundant bone protein that is difficult to detect using high-throughput tandem mass spectrometry (MS/MS) proteomic approaches from bone protein extracts, and is predominantly detected by non-MS immunological methods.
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports
Scientific Reports
Tough natural nanocomposites like bone, nacre and sea sponges contain within their hierarchy, a mineral (phosphate, silicate or carbonate) phase that interacts with an organic phase. In bone, the role of mineral ultrastructure (organization, morpholo
Publikováno v:
Molecular & Cellular Proteomics. 14:1546-1555
Serum osteocalcin (Oc) concentration is a highly specific measure of bone turnover, but its circulating proteoform(s) have not been well defined. Based on immunological methods, the major forms are thought to be the intact polypeptide and a large N-t
Autor:
Frank Buttgereit, Sylvia J. Gasparini, Markus J. Seibel, Colin R. Dunstan, Holger Henneicke, Dmitri Svistounov, Tara C. Brennan-Speranza, Hong Zhou, Gregory J. Cooney, Caren M. Gundberg, Victoria C. Cogger, Katharina I. Blankenstein, Uta Heinevetter, Yaqing Zhang
Publikováno v:
Journal of Clinical Investigation. 122:4172-4189
Long-term glucocorticoid treatment is associated with numerous adverse outcomes, including weight gain, insulin resistance, and diabetes; however, the pathogenesis of these side effects remains obscure. Glucocorticoids also suppress osteoblast functi
Autor:
Clifford J. Rosen, Randal A. Cross, William A. Halteman, Walter J. Jakubas, Richard M. Seger, Rita L. Seger, Frederick A. Servello, Caren M. Gundberg, Tai C. Chen, Thomas O. Carpenter, Michael F. Holick, Duane H. Keisler, Robert Causey
Publikováno v:
Bone. 49:1205-1212
Ursine hibernation uniquely combines prolonged skeletal unloading, anuria, pregnancy, lactation, protein recycling, and lipolysis. This study presents a radiographic and biochemical picture of bone metabolism in free-ranging, female American black be