Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Carel W. Funke"'
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 112:191-199
The article describes approaches for the synthesis and analysis of isotopically (2H, 3H, 13C, 14C, 35S) labelled drugs necessary for the development of a pharmacologically active compound into a registered drug. Special features such as isotope effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86252e01258f9bdb2dafdaed69b10c44
https://doi.org/10.1002/recl.19931120218
https://doi.org/10.1002/recl.19931120218
Autor:
Frans M. Kaspersen, Gerrit L. M. van de Laar, Jan van Acquoy, Gerard N. Wagenaars, Carel W. Funke
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 103:32-36
Isotopic fractionation in HPLC can be observed for mianserin when deuterated in the piperazine ring, except on position 14b. This isotope effect is caused by an increase in basicity upon introduction of deuterium. No effects of deuteration on the con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::994d498114012138d141f6bd67f35f6c
https://doi.org/10.1002/recl.19841030107
https://doi.org/10.1002/recl.19841030107
Autor:
Dirk Leysen, Jan Kelder, Victor J. Nickolson, Thus de Boer, L. P. C. Delbressine, Carel W. Funke
Publikováno v:
Journal of Pharmacy and Pharmacology. 49:403-411
Although the chemical structures of the antidepressants mirtazapine and mianserin are closely related there are considerable differences in their biological properties. To find an explanation of this, various physicochemical properties of mirtazapine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf08b1ef20218a4ef8f7be5c346242c
https://doi.org/10.1111/j.2042-7158.1997.tb06814.x
https://doi.org/10.1111/j.2042-7158.1997.tb06814.x
Autor:
P. van der Sluis, Jan Kelder, Carel W. Funke, Huub Kooijman, Jan M. Kroon, V. J. van Geerestein, Jan A. Kanters
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f135b0e9bda7631942909b52bc3504e
https://doi.org/10.1002/chin.199202268
https://doi.org/10.1002/chin.199202268
Autor:
Carel W. Funke, Jan-Remt Mellema, Frans M. Kaspersen, Gerard N. Wagenaars, Irene H. G. Schlachter
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 29:613-616
To increase the bio-availability of naturally occurring steroids, esterification of the 17-hydroxy position is a useful approach. Besides (branched) alkanecarboxylic acids1) and cyclohexanecarboxylic acid2) also cyclooctyl acetic acid (1) was applied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bda9360234f9febc283ef64502b55567
https://doi.org/10.1002/jlcr.2580290514
https://doi.org/10.1002/jlcr.2580290514
Publikováno v:
Canadian Journal of Chemistry. 68:1818-1820
A recently developed procedure (Buist etal., J. Chem. Soc. Perkins II, 169 (1990)) has been used to study the kinetics of detritiation of [10,10-3H] mianserin and two other structurally related compounds in highly basic media. Over the H− range 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf6c37b663c6988257f05d4f83d2f6f
https://doi.org/10.1139/v90-283
https://doi.org/10.1139/v90-283
Autor:
Paul van der Sluis, Jan A. Kanters, Vincent J. van Geerestein, Carel W. Funke, Huub Kooijman, Jan Kelder, Jan Kroon
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1581
The crystal and molecular structure of vecuronium bromide {1-[2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)-2-(piperidin-1-yl)androstan-16-yl]-1-methylpiperidinium bromide}, a potent non-depolarizing neuromuscular blocking agent, has been determined by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d59f888c17eabedb70c41312ae8a142
https://doi.org/10.1039/p29910001581
https://doi.org/10.1039/p29910001581
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 102:457-460
Eleven deuterated analogues of mianserin have been synthesized and analyzed by 1H and 13C NMR. Based on these compounds, the aromatic part of the 1H spectrum of mianserin could be interpreted.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46082d8c19d901da704789b3b1f13555
https://doi.org/10.1002/recl.19831021007
https://doi.org/10.1002/recl.19831021007
Publikováno v:
Recueil des Travaux Chimiques des Pays-Bas. 102:450-453
The synthesis, purification and analysis of three tritiated neuropeptides are described. Org 2766 (an ACTH (4-9) analogue) and Org GK 78 (des-Tyr-γ-endorphin) were labelled in the aromatic ring of phenylalanine by catalytic deiodination of the (p-io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abd7cca2f120528ca22978c3bb3f901f
https://doi.org/10.1002/recl.19831021005
https://doi.org/10.1002/recl.19831021005
Autor:
Jan-Remt Mellema, P. Hoogerhout, Gerard N. Wagenaars, D. Evenberg, C. A. A. Van Boeckel, Jan Poolman, G. A. Van Der Marel, A. W. M. Lefeber, J. H. Van Booma, Carel W. Funke
Publikováno v:
Journal of Carbohydrate Chemistry. 7:399-416
The synthesis of spacer-containing fragments of the capsular poly-saccharide of H. influenzas, comprising two and three repeating units (9a and 9b, respectively), is presented. Ribosylribitol building blocks 1 and 2 were coupled with bis [1-benzotria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a39bbc02783d0d89ca92068315d1ce
https://doi.org/10.1080/07328308808058933
https://doi.org/10.1080/07328308808058933